Nav: Home

Aspirin may prevent air pollution harms

October 02, 2019

A new study is the first to report evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin may lessen the adverse effects of air pollution exposure on lung function. The team of researchers from the Columbia Mailman School of Public Health, Harvard Chan School of Public Health, Boston University School of Medicine published their findings in the American Journal of Respiratory and Critical Care Medicine.

The researchers analyzed a subset of data collected from a cohort of 2,280 male veterans from the greater Boston area who were given tests to determine their lung function. The average age of participants was 73 years. The researchers examined the relationship between test results, self-reported NSAID use, and ambient particulate matter (PM) and black carbon in the month preceding the test, while accounting for a variety of factors, including the health status of the subject and whether or not he was a smoker. They found that the use of any NSAID nearly halved of the effect of PM on lung function, with the association consistent across all four weekly air pollution measurements from same-day to 28 days prior to the lung function test.

Because most of the people in the study cohort who took NSAIDs used aspirin, the researchers say the modifying effect they observed was mainly from aspirin, but add that effects of non-aspirin NSAIDs are worthy of further exploration. While the mechanism is unknown, the researchers speculate that NSAIDs mitigate inflammation brought about by air pollution.

"Our findings suggest that aspirin and other NSAIDs may protect the lungs from short-term spikes in air pollution," says first and corresponding author Xu Gao, PhD, a post-doctoral research scientist in the Department of Environmental Health Sciences at the Columbia Mailman School. "Of course, it is still important to minimize our exposure to air pollution, which is linked to a host of adverse health effects, from cancer to cardiovascular disease."

"While environmental policies have made considerable progress toward reducing our overall exposure to air pollution, even in places with low levels of air pollution, short-term spikes are still commonplace," says senior author Andrea Baccarelli, MD, PhD, chair of the Department of Environmental Health Sciences at the Columbia Mailman School. "For this reason, it is important to identify means to minimize those harms."

An earlier study by Baccarelli found that B vitamins may also play a role in reducing the health impact of air pollution.
-end-
Co-authors include Brent Coull, Xihong Lin, and Joel Schwartz at Harvard; and Pantel Vokonas at the Boston University School of Medicine.The current study was supported by grants from the National Institute of Environmental Health Sciences (ES009089, ES021733, ES025225, ES027747). The VA Normative Aging Study is supported by the Cooperative Studies Program/Epidemiology Research and Information Center of the U.S. Department of Veterans Affairs and is a component of the Massachusetts Veterans Epidemiology Research and Information Center in Boston.

Columbia University Mailman School of Public Health

Founded in 1922, the Columbia University Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Columbia Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 450 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,300 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Columbia Mailman School is also home to numerous world-renowned research centers, including ICAP and the Center for Infection and Immunity. For more information, please visit http://www.mailman.columbia.edu.

Columbia University's Mailman School of Public Health

Related Air Pollution Articles:

Exploring the neurological impact of air pollution
Air pollution has become a fact of modern life, with a majority of the global population facing chronic exposure.
Spotting air pollution with satellites, better than ever before
Researchers from Duke University have devised a method for estimating the air quality over a small patch of land using nothing but satellite imagery and weather conditions.
Exposure to air pollution during pregnancy is associated with growth delays
A new study by the Barcelona Institute for Global Health (ISGlobal) has found an association between exposure to air pollution during pregnancy and delays in physical growth in the early years after birth.
Nearly half of US breathing unhealthy air; record-breaking air pollution in nine cities
Amid the COVID-19 pandemic, the impact of air pollution on lung health is of heightened concern.
Air pollution linked to dementia and cardiovascular disease
People continuously exposed to air pollution are at increased risk of dementia, especially if they also suffer from cardiovascular diseases, according to a study at Karolinska Institutet in Sweden published in the journal JAMA Neurology.
New framework will help decide which trees are best in the fight against air pollution
A study from the University of Surrey has provided a comprehensive guide on which tree species are best for combating air pollution that originates from our roads -- along with suggestions for how to plant these green barriers to get the best results.
Air pollution is one of the world's most dangerous health risks
Researchers calculate that the effects of air pollution shorten the lives of people around the world by an average of almost three years.
The world faces an air pollution 'pandemic'
Air pollution is responsible for shortening people's lives worldwide on a scale far greater than wars and other forms of violence, parasitic and insect-born diseases such as malaria, HIV/AIDS and smoking, according to a study published in Cardiovascular Research.
Air pollution in childhood linked to schizophrenia
Children who grow up in areas with heavy air pollution have a higher risk of developing schizophrenia.
Air pollution can worsen bone health
A new study by the CHAI Project with over 3,700 people in India associates air pollution with a higher risk to develop osteoporosis.
More Air Pollution News and Air Pollution Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Making Amends
What makes a true apology? What does it mean to make amends for past mistakes? This hour, TED speakers explore how repairing the wrongs of the past is the first step toward healing for the future. Guests include historian and preservationist Brent Leggs, law professor Martha Minow, librarian Dawn Wacek, and playwright V (formerly Eve Ensler).
Now Playing: Science for the People

#566 Is Your Gut Leaking?
This week we're busting the human gut wide open with Dr. Alessio Fasano from the Center for Celiac Research and Treatment at Massachusetts General Hospital. Join host Anika Hazra for our discussion separating fact from fiction on the controversial topic of leaky gut syndrome. We cover everything from what causes a leaky gut to interpreting the results of a gut microbiome test! Related links: Center for Celiac Research and Treatment website and their YouTube channel
Now Playing: Radiolab

The Flag and the Fury
How do you actually make change in the world? For 126 years, Mississippi has had the Confederate battle flag on their state flag, and they were the last state in the nation where that emblem remained "officially" flying.  A few days ago, that flag came down. A few days before that, it coming down would have seemed impossible. We dive into the story behind this de-flagging: a journey involving a clash of histories, designs, families, and even cheerleading. This show is a collaboration with OSM Audio. Kiese Laymon's memoir Heavy is here. And the Hospitality Flag webpage is here.