New patent on virtual guided-bronchoscopy system to help diagnose lung cancer

October 04, 2012

A team of researchers from the Institute of Industrial and Control Engineering (IOC) of the Universitat Politècnica de Catalunya · BarcelonaTech (UPC) and the Pulmonology Research Group of the Bellvitge Biomedical Research Institute (IDIBELL) has patented an improved virtual bronchoscopy system designed to enhance endoscopic examination of peripheral lung lesions, that is, small nodules located in more distal branches of the bronchi. The system, designed to improve lung cancer diagnosis, aids physician decision making regarding whether a bronchoscopy is necessary and so avoids possible risks and discomfort for the patient.

For standard lung cancer detection procedures, virtual bronchoscopy enables lung lesions to be examined from 3D reconstructions of the tracheobronchial tree. After a radiology exam, the physician can plan the bronchoscopy, which is performed using a flexible bronchoscope. This medical device is used for lung treatment and diagnosis and for the extraction of tissue samples for biopsy purposes.

The UPC-IDIBELL system, developed from virtual bronchoscopy imaging based on 2D computed tomography scans, enables the pulmonologist to virtually explore a patient's airways and to simulate, using a tactile feedback device, the flexible bronchoscope movements to be made during the real exam. The pulmonologist can thus very realistically plan an access route from the trachea to the peripheral lung lesion; it will also be possible to determine whether the tip of the bronchoscope will reach the injury, and, if not, to calculate the distance remaining and the biopsy technique to use. During the planning state, reaching the conclusion that pulmonary tissue is not accessible means that a futile exam is avoided.

The novelty of the system is that, unlike current virtual bronchoscopy systems, it takes bronchoscope geometry and kinematic constraints into account. What the researchers have done is design specific software and adapt automated movement planning techniques to map paths from the trachea to peripheral lung lesions. The tip of the bronchoscope is modelled as a kinematic chain with a mobile base and three degrees of freedom: the curvature of the tip, rotation around the axis, and forward movement.
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The development of this novel system is part of the GUIBRO project carried out by Jan Rosell, Paolo Cabras and Alexander Pérez, all attached to the UPC's Institute of Industrial and Control Engineering, and Antoni Rosell, researcher of IDIBELL's Pulmonology Research Group. The three-year project has received two health research fund grants, awarded by the Spanish Ministry of Economy and Competitiveness via the Carlos III Health Institute. The project mission is the study, implementation and evaluation of guided bronchoscopy systems for peripheral lung lesion exams.

IDIBELL-Bellvitge Biomedical Research Institute

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