Nav: Home

Study identifies a potential biomarker for pancreatic tumor grade

October 04, 2016

Pancreatic ductal adenocarcinoma (PDA) is one of the leading causes of cancer-related deaths, and this high mortality rate is bolstered by a lack of diagnostic techniques to assess tumor grade and severity. This month in the JCI, a team led by Richard Tomasini at INSERM analyzed the expression of proteins in PDA tumors to determine how cells in the tissue surrounding tumors contribute to tumor aggressiveness. They found that cells in tumor-surrounding tissue supported increased tumor growth and metastasis in PDA tumors when they contained extracellular vesicles that expressed a protein called annexin 6. Injection of annexin 6-expressing vesicles into mice increased tumor growth and metastasis, whereas depletion of these vesicles impaired it. Moreover, the levels of annexin 6-expressing vesicles detected in the serum of patients with PDA correlated with patient survival. These findings indicate that measuring levels of annexin 6-expressing vesicles may be a useful diagnostic marker for grading PDA tumors. Moreover, interrupting the activity of these vesicles may be an effective strategy for treating PDA patients.
-end-
TITLE: Cancer-associated fibroblast-derived annexin A6+extracellular vesicles support pancreatic cancer aggressiveness

AUTHOR CONTACT:

Richard Tomasini
INSERM U1068, CRCM
richard.tomasini@inserm.fr

View this article at:http://www.jci.org/articles/view/87734?key=d7deba1e628a4fbaa984

JCI Journals

Related Metastasis Articles:

Cancer metastasis: The unexpected perils of hypoxia
The low oxygen concentrations that prevail in many tumors enhance their propensity to metastasize to other tissues.
New bone-in technique tests therapies for breast cancer metastasis
A new laboratory technique developed by researchers at Baylor College of Medicine and other institutions can rapidly test the effectiveness of treatments for life-threatening breast cancer metastases in bone.
Tighten the grip on metastasis
Metastasis is the major cause of cancer-related death and its appearance remains a phenomenon that is difficult to predict and manage.
Epigenetic changes promoting cancer metastasis identified
Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumors to other parts of the body.
Tumor cells are dependent on fat to start metastasis
A study headed by Salvador Aznar Benitah, ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona), and published today in Nature identifies metastasis-initiating cells through a specific marker, namely the protein CD36.
Researchers identify protein required for breast cancer metastasis
Researchers have identified a new pathway and with it a protein, BRD4, necessary for breast cancer cells to spread.
Stopping breast cancer metastasis in its tracks
A new Tel Aviv University study finds that combining genetic therapy with chemotherapy delivered to a primary tumor site is extremely effective in preventing breast cancer metastasis.
A new animal model to understand metastasis in sarcomas
Researchers from IDIBELL have developed a modified version of an orthotopic model to recreate the metastatic steps in Ewing sarcoma, the second most common bone tumor in children and adolescents.
How breast cancer cells slide to metastasis
The spreading of cancer cells from one part of the body to another, a process known as metastasis, is the leading cause of death among cancer patients.
Stop the growth: U-M researchers take aim at cancer metastasis
Most cancer drugs today work by attacking tumor growth. Researchers at the University of Michigan Life Sciences Institute, however, are taking aim at a different piece of the cancer puzzle -- preventing its ability to spread to new parts of the body, known as metastasis, which is the cause of most cancer deaths.

Related Metastasis Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#530 Why Aren't We Dead Yet?
We only notice our immune systems when they aren't working properly, or when they're under attack. How does our immune system understand what bits of us are us, and what bits are invading germs and viruses? How different are human immune systems from the immune systems of other creatures? And is the immune system so often the target of sketchy medical advice? Those questions and more, this week in our conversation with author Idan Ben-Barak about his book "Why Aren't We Dead Yet?: The Survivor’s Guide to the Immune System".