African ancestry contributes to kidney disease risk in Hispanics/Latinos

October 05, 2016

MAYWOOD, IL - African ancestry contributes to the risk of chronic kidney disease among some Hispanic/Latino adults, according to a study co-authored by Loyola University Chicago researchers.

The study by first author Holly Kramer, MD, MPH, and colleagues is published in the Journal of the American Society of Nephrology. Dr. Kramer is an associate professor in the Department of Public Health Sciences and in the Division of Nephrology and Hypertension of Loyola University Chicago Stritch School of Medicine.

The study included 12,226 U.S. Hispanic/Latino adults. Participants were examined for signs of kidney disease and for genetic variants indicating African ancestry - a sickle cell trait and two alternative forms of a gene called APOL1. (A person with sickle cell trait inherits one copy of a mutated gene, but does not get sickle cell disease, which requires copies from both parents.)

The study found that the African genetic variants were more common among Caribbean Hispanic/Latinos (including Puerto Ricans, Dominicans and Cubans) than among mainland Hispanics/Latinos. Hispanic/Latinos who had the African genetic variants were more likely to have albuminuria (an early sign of kidney disease) and/or a low glomerular filtration rate (a sign of decreased kidney function).

Researchers concluded that genetic variants that confer chronic kidney disease risk and are associated with African ancestry are also associated with increased kidney disease risk among Hispanic/Latino adults.
-end-
The study is titled "African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanic/Latinos."

In addition to Dr. Kramer, other Loyola co-authors of the study are Bamidele Tayo, PhD, and Ramon Durazo-Arvizu, PhD. Corresponding author is Nora Franceschini, MD, MPH, of the University of North Carolina.

Loyola University Health System

Related Kidney Disease Articles from Brightsurf:

Waistline matters in kidney disease
Does fat matter in kidney disease? The investigators found that all measures of higher abdominal fat content (including visceral fat, liver fat, or subcutaneous fat) and slower walk times were associated with increased levels of cardiometabolic risk factors in adults with non-dialysis dependent kidney disease.

Reducing urinary protein for patients with rare kidney disease slows kidney decline
New findings show that reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis can significantly slow declines in kidney function and extend time before patients' kidneys fail.

Antioxidant agent may prevent chronic kidney disease and Parkinson's disease
Researchers from Osaka University developed a novel dietary silicon-based antioxidant agent with renoprotective and neuroprotective effects.

Acute kidney injury and end stage kidney disease in severe COVID-19
Many COVID-19 patients experience hematuria, proteinuria and elevated serum creatinine concentration early in the course of the disease.

Genes tell a story about diabetic kidney disease
Studying Finnish genes leads to unique revelations about the development of a serious complication of diabetes, and informs an ongoing genomic study of a Singaporean cohort as part of Singapore's Diabetes Study in Nephropathy and other Microvascular Complications (DYNAMO).

New study provides insight into chronic kidney disease
Researchers have further analyzed a known signaling pathway they believe brings them one step closer to understanding the complex physiology of patients with chronic kidney disease (CKD), which might provide a path to new treatment options.

Predicting risk of chronic kidney disease
Data from about 5 million people (with and without diabetes) in 28 countries were used to develop equations to help identify people at increased five-year risk of chronic kidney disease, defined as reduced estimated glomerular filtration rate (eGFR).

A healthy diet may help prevent kidney disease
In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease.

Is kidney failure a man's disease?
A new analysis of the ERA-EDTA Registry [1] reveals a striking gender difference in the incidence and prevalence of end-stage renal disease.

Chronic kidney disease: Everyone's concern
850 million people worldwide are affected by kidney disease. This worrying figure was published last June.

Read More: Kidney Disease News and Kidney Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.