Nav: Home

New method to detect aging cells developed by researchers

October 05, 2016

Scientists have discovered a new way to look for ageing cells across a wide range of biological materials; the new method will boost understanding of cellular development and ageing as well as the causes of diverse diseases.

Frustrated by the limitations of commercially available biomarkers - researchers led by The University of Manchester's Professor Paul Townsend and senior author of the resulting paper, and honorary professor at Manchester, Professor Vassilis Gorgoulis, have developed a universally applicable method to assess senescence across biomedicine, from cancer research to gerontology.

Cellular senescence is a fundamental biological process involved in every day embryonic and adult life, both good - for normal human development - and, more importantly to researchers, dangerous by triggering disease conditions. Up to now available senescence detecting biomarkers have very limited and burdensome application. Therefore, a more effective, precise and easy-to-use biomarker would have considerable benefits for research and clinical practice.

"The method we have developed provides unprecedented advantages over any other available senescence detection products - it is straight-forward, sensitive, specific and widely applicable, even by non-experienced users," said Professor Townsend.

"In addition to helping researchers make significant new breakthroughs into the causes of diseases - including cancer - through more effective understanding of senescence in cells, the new process will also aid the impact of emerging cellular rejuvenation therapies.

"By the better identification - and subsequently elimination of - senescent cells, tissues can be rejuvenated and the health span extended."

The research on the new methodology - published as 'Robust, universal biomarker to detect senescent cells in biological specimens' in the journal Ageing Cell - has led to two pending UK patents.
-end-
Notes to editors

Interviews on request

Follow @UomNews on Twitter
The latest media videos are on our YouTube page
The latest news and coverage on Google+
A record of the University in the news is on our Scoop.it page

University of Manchester

Related Biomarkers Articles:

Deep biomarkers of aging and longevity: From research to applications
The deep age predictors can help advance aging research by establishing causal relationships in nonlinear systems.
Semen miRNAs could be non-invasive biomarkers for prostate cancer
Researchers of the Human Molecular Genetics group at the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr.
Scientists have found longevity biomarkers
An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity.
After concussion, biomarkers in the blood may help predict recovery time
A study of high school and college football players suggests that biomarkers in the blood may have potential use in identifying which players are more likely to need a longer recovery time after concussion, according to a study published in the July 3, 2019, online issue of Neurology, the medical journal of the American Academy of Neurology.
3D-printed device detects biomarkers of preterm birth
Preterm birth (PTB) -- defined as birth before the 37th week of gestation -- is the leading complication of pregnancy.
NUS researchers identified new biomarkers associated with 'chemobrain'
Researchers from the National University of Singapore have identified new biomarkers related to the cognitive impairment associated with cancer known as chemobrain.
Novel biomarkers for noninvasive diagnosis of NAFLD-related fibrosis
With an estimated 25% of people worldwide affected by nonalcoholic fatty liver disease (NAFLD), there is a large unmet need for accurate, noninvasive measures to enhance early diagnosis and screening of hepatic fibrosis.
Novel biomarkers & therapeutic targets for atherosclerotic cardiovascular diseases
In this review, the researchers describe the analytical techniques and workflow used in untargeted metabolomics.
Biomarkers facilitate early detection of glaucoma
Researchers at Ruhr-Universität Bochum have identified new potential biomarkers that may facilitate early detection of glaucoma in patients.
New biomarkers of inflammation identified as risk of polyneuropathy
Polyneuropathy is one of the most common complications in people with diabetes.
More Biomarkers News and Biomarkers Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

In & Out Of Love
We think of love as a mysterious, unknowable force. Something that happens to us. But what if we could control it? This hour, TED speakers on whether we can decide to fall in — and out of — love. Guests include writer Mandy Len Catron, biological anthropologist Helen Fisher, musician Dessa, One Love CEO Katie Hood, and psychologist Guy Winch.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab