Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny

October 05, 2020

Aging-US recently published "From Causes of Aging to Death from COVID-19" by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

The Review covers:The author contends that at its deepest level, aging is driven by inappropriately high cellular functioning. The hyperfunction theory of quasi-programmed aging explains why COVID-19 vulnerability is an age-dependent syndrome, linking it to other age-related diseases.

These conditions are typical age-related diseases: hypertension, diabetes, obesity, ischemic heart disease, chronic obstructive pulmonary disease, and other diseases.

This is because pre-existing conditions are manifestations of biological age, ultimately meaning that A. aging and B. diseases are two sides of the same coin.

The Blagosklonny Research Team goes on to highlight that an anti-aging intervention, such as rapamycin, may slow aging and age-related diseases, potentially decreasing COVID-19 vulnerability.

The Aging-US Review also reported that as soon as the COVID-19 epidemic started, it became clear that COVID-19 vulnerability is an aging-dependent condition, and the use of rapamycin was immediately suggested by independent researchers.

By decreasing biological age and preventing age-related diseases, long-term rapamycin therapy may, in theory, decrease the COVID-19 mortality rate in the elderly.

As specifically discussed in the Review section titled "Figuratively, rapamycin rejuvenates immunity", mTOR inhibitors can improve immunity to viral infections, improve immunization and vaccination to some viruses such as the flu.

The hypothetical graph in the absence of COVID-19. COVID-19 vulnerability increases exponentially with age.

Then as discussed in the section "Cytokine storm is a hyperfunction", cytokine storm and hyper-inflammation is the main cause of death in COVID-19 pneumonia Rapamycin, an anti-inflammatory agent, inhibits hyper-functions, cellular senescence and decrease secretion of cytokines.
-end-
DOI - https://doi.org/10.18632/aging.103493

Full text - https://www.aging-us.com/article/103493/text#fulltext

Correspondence to - Mikhail V. Blagosklonny Blagosklonny@oncotarget.com or Blagosklonny@rapalogs.com

Keywords - aging, mTOR, rapalogs, senolytics, SARS-CoV-2, COVID-19, coronavirus, Impact Journals, Aging-US

Impact Journals LLC

Related Aging Articles from Brightsurf:

Aging-US: 'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny
Aging-US recently published ''From Causes of Aging to Death from COVID-19'' by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

Understanding the effect of aging on the genome
EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues.

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging.

Aging memories may not be 'worse, 'just 'different'
A study from the Department of Psychological & Brain Sciences in Arts & Sciences adds nuance to the idea that an aging memory is a poor one and finds a potential correlation between the way people process the boundaries of events and episodic memory.

A new biomarker for the aging brain
Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article.

The first roadmap for ovarian aging
Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear.

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.

Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.

Intelligence can link to health and aging
For over 100 years, scientists have sought to understand what links a person's general intelligence, health and aging.

Read More: Aging News and Aging Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.