C. difficile infection not always associated with antibiotic use

October 06, 2008

Community-acquired Clostridium difficile (C. difficile) infection occurred in a significant proportion of people with no recent exposure to antibiotics, with 53% having no exposure in the 45 days preceding hospitalization and 46% having no exposure in the preceding 90 days, according to a new study published in CMAJhttp://www.cmaj.ca/press/pg767.pdf. While C.difficile is mainly known as a hospital-acquired infection, the study participants, aged 65 and over, had not been hospitalized for at least 90 days before being admitted for C. difficile.

Dr. Sandra Dial and the team of McGill University-based authors conclude "testing for C. difficile should be considered in community patients with diarrhea in whom a history of antibiotic exposure cannot be elicited."

In a related commentary http://www.cmaj.ca/press/pg747.pdf, Dr. Ed Kuijper and Prof. Jaap van Disselof Leiden University in the Netherlands write that while the lack of antibiotic exposure in people admitted to hospital with C. difficile is interesting, it needs to be determined whether C.difficile is occurring in younger people without risk factors. Several studies suggest this may be the case. The authors state "there is an urgent need to identify and better characterize potential risk factors for community-acquired C.difficile infection to explain the large proportion of cases not linked to recent antibiotic therapy or hospital stays."
-end-
Contact for research: Isabelle Kling, isabelle.kling@muhc.mcgill.ca, McGill University Health Centre, (514) 934 1934, # 36419 for Dr. Sandra Dial

Contact for commentary: Dr. Ed Kuijper, 31-06-11113104, e.j.kuijper@lumc.nl or Prof. Jaap van Dissel, j.t.van_dissel@lumc.nl, Centre for Infectious Diseases, Leiden University Medical Centre, the Netherlands. Please note the time zone is 6 hours ahead of EDST.

Canadian Medical Association Journal

Related Antibiotics Articles from Brightsurf:

Insights in the search for new antibiotics
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology, that addresses the gap in the discovery of new antibiotics.

New tricks for old antibiotics
The study published in the journal Immunity reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection.

Benefits, risks seen with antibiotics-first for appendicitis
Antibiotics are a good choice for some patients with appendicitis but not all, according to study results published today in the New England Journal of Medicine.

How antibiotics interact
Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics / study in 'Nature Communications'

Are antivitamins the new antibiotics?
Antibiotics are among the most important discoveries of modern medicine and have saved millions of lives since the discovery of penicillin almost 100 years ago.

Hygiene reduces the need for antibiotics by up to 30%
A new paper published in the American Journal of Infection Control (AJIC), finds improved everyday hygiene practices, such as hand-washing, reduces the risk of common infections by up to 50%, reducing the need for antibiotics, by up to 30%.

Antibiotics: City dwellers and children take the most
City dwellers take more antibiotics than people in rural areas; children and the elderly use them more often than middle-aged people; the use of antibiotics decreases as education increases, but only in rich countries: These are three of the more striking trends identified by researchers of the NRW Forschungskolleg ''One Health and Urban Transformation'' at the University of Bonn.

Metals could be the link to new antibiotics
Compounds containing metals could hold the key to the next generation of antibiotics to combat the growing threat of global antibiotic resistance.

Antibiotics from the sea
The team led by Prof. Christian Jogler of Friedrich Schiller University, Jena, has succeeded in cultivating several dozen marine bacteria in the laboratory -- bacteria that had previously been paid little attention.

Antibiotics not necessary for most toothaches, according to new ADA guideline
The American Dental Association (ADA) announced today a new guideline indicating that in most cases, antibiotics are not recommended for toothaches.

Read More: Antibiotics News and Antibiotics Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.