Major grants support immunology, transplant and diabetes research at the University of Chicago

October 06, 1999

At a campus press briefing on October 6, the Juvenile Diabetes Foundation (JDF) and the National Institute of Allergy and Infectious Diseases (NIAID) announced two major, closely related, multi-year grants to research teams headquartered at the University of Chicago.

The JDF has awarded $7.5 million over a five-year period to establish the JDF Center for Islet Transplantation at the University of Chicago/University of Minnesota. The NIAID has launched a seven-year, $144-million initiative, involving nearly 40 research institutions to be known as the Collaborative Network for Clinical Research on Immune Tolerance.

Both projects will be directed by Jeffrey Bluestone, Ph.D., the Daniel K. Ludwig Professor of Pathology, Chairman of the Committee on Immunology and Director of the Ben May Institute for Cancer Research at the University of Chicago.

The JDF Center for Islet Transplantation, made possible by generous support from the McDonough Family Foundation in Chicago, will advance the use of transplants of insulin-producing pancreatic islets as a cure for diabetes. It will focus on finding new ways to prevent the body from rejecting islet transplants without causing dangerous side effects.

The Collaborative Network will concentrate on developing and testing new ways to induce immune tolerance by selectively modulating the immune system to inhibit harmful responses yet keep protective ones intact. This strategy promises to improve the success of transplants as well as treatments for autoimmune diseases such as type 1 diabetes, lupus and rheumatoid arthritis, which destroy the body's own cells.

"These are two vitally important, far-reaching and daring projects and we are pleased and honored that both will be based at the University of Chicago," said Glenn Steele, M.D., Ph.D., Dean of the Division of the Biological Sciences and Vice President for Medical Affairs at the University. "This builds on our remarkable history of advances in transplantation, immunology and diabetes research and recognizes the ongoing leadership of our many superb scientists, such as the research teams pulled together by Professor Bluestone."

In patients with type 1, or juvenile, diabetes, the insulin-producing beta cells, found in pancreatic islets, have been destroyed. Scientists have been tantalized for more than 25 years by the idea of transplanting healthy islets but frustrated by the difficulty of protecting those islets from the recipient's immune system, which rejects foreign tissue. Current techniques of protecting those islets suppress the entire immune system, increasing the recipient's risk of infection and cancer. "It's like tearing down your house, just to get rid of the mice," said Bluestone.

The JDF Center will try to improve islet transplantation through three major projects. Bluestone's laboratory will concentrate on developing new, more-specific therapies to induce immune tolerance by eliminating the components that attack the transplanted cells without impairing the rest of the immune system, allowing it to continue to defend the body against infection.

A team led by Bernard Hering, M.D., co-director of the JDF Center and an islet-transplant specialist at the University of Minnesota, will coordinate testing of these new therapies in human clinical trials.

A third team led by Kenneth Polonsky, professor of medicine and section chief of endocrinology at the University of Chicago and co-director of the JDF Center, will closely monitor all patients and their transplanted islets and assess the genetic and immunologic signals that result from these new therapies. These efforts to uncover exactly what triggers rejection could serve as a guide to develop even more effective therapies.

"Every one of us who has diabetes, or who has children with diabetes, knows that insulin is not a cure," said JDF Chairman of the Board John J. McDonough. "This new JDF Center moves us closer to the day when we will be free from daily injections, constant concern about blood sugar levels, and the dangers of blindness and the other debilitating health effects of type 1 diabetes."

The Collaborative Network for Clinical Research on Immune Tolerance
Immune-mediated diseases, such as type 1 diabetes or arthritis are very common, affecting tens of millions of Americans, including more than 19,000 organ-transplant recipients each year. These disorders result in direct and indirect annual costs of more than $100 billion in the United States alone. Successful and lasting induction of immune tolerance could potentially eradicate autoimmune disease and eliminate the need for permanent immune suppression in transplant patients.

The Collaborative Network -- which includes more than 70 of the world's leading immunology researchers and clinical specialists in transplantation and autoimmune disease from nearly 40 institutions in nine countries, the authors of more than 10,000 research articles -- will coordinate human clinical testing of new therapies designed to bring about immune tolerance.

"This collaboration brings together some of the brightest minds in immunology and flows from NIAID's plan to accelerate clinical trials for novel approaches to modulate immune responses," said NIAID Director Anthony S. Fauci, M.D. "Immune tolerance research has great potential to help millions afflicted with some of the most debilitating and chronic immune mediated diseases."

The goal is to learn how to persuade the immune system to accept certain beneficial tissues yet remain vigilant against harmful invaders. The Network will initially focus on the challenges presented by the rejection of foreign tissues such as a transplanted kidney or insulin-producing beta cells and on the autoimmune diseases such as type I diabetes, rheumatoid arthritis, multiple sclerosis or inflammatory bowel disease. Eventually, it will expand to include clinical studies of immunologic treatments of asthma and allergic diseases.

Recent tests of new methods to induce immune tolerance have shown promising results in both animal models and early human clinical studies. Network researchers will accelerate testing of these and other tolerogenic approaches and will develop and evaluate methods to monitor the induction, maintenance and loss of immune tolerance in humans.

"We have established a collaboration that will be open and inclusive, with the flexibility to capitalize on emerging opportunities for any tolerogenic approaches," said Bluestone, a recognized pioneer in developing tolerogenic therapy.

The NIAID will supply more than $128 million for the Network, with another $14 million provided by the JDF, and additional support from the National Institute of Diabetes and Digestive and Kidney Diseases.

University of Chicago Medical Center

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to