Nav: Home

Antipsychotics linked to accumulation of hospital days in persons with Alzheimer's disease

October 07, 2019

People with Alzheimer's disease who used antipsychotic drugs had a higher number of accumulated hospital days than people with Alzheimer's disease who did not use antipsychotics, according to a new study from the University of Eastern Finland. The results were published in the Journal of American Medical Directors Association. During a two-year follow-up, persons who initiated antipsychotic drugs accumulated approximately eleven more hospital days per person-year.

People who initiated an antipsychotic drug accumulated more hospital days than non-initiators due to dementia, mental and behavioural disorders, diseases of the respiratory and genitourinary system, cardiovascular disorders, and different symptoms such as fatigue. In addition, people who initiated an antipsychotic drug had more hospital days due to their caregivers' days off.

All-cause hospitalisations have been suggested to proxy overall drug safety, and therefore the results may partially reflect adverse effects. However, these results also reflect difficulties in the treatment of severe behavioural and psychological symptoms of dementia. Thus, another reason for a higher accumulation of hospital days is the indication behind antipsychotic use.

The study was based on the nationwide register-based MEDALZ cohort that includes all community-dwelling persons with a clinically verified diagnosis of Alzheimer's disease in Finland during 2005-2011 (70,718 people). Data on antipsychotic use was extracted from the Finnish Prescription Register. Comorbidities, concomitant medications and time since AD diagnosis were accounted for in the analyses. The study was conducted at the University of Eastern Finland and funded by the Academy of Finland.
-end-
Contact information:

Postdoctoral Researcher Marjaana Koponen, University of Eastern Finland, School of Pharmacy, marjaana.koponen(at)uef.fi

Reference:

Koponen M, Lavikainen P, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S, Tolppanen AM: Accumulation of hospital days among antipsychotic initiators with Alzheimer's disease. Journal of the American Medical Directors Association. doi: 10.1016/j.jamda.2019.07.009. In press, available online 26 Aug 2019:

https://www.jamda.com/article/S1525-8610(19)30561-4/fulltext

University of Eastern Finland

Related Dementia Articles:

Digital solutions for dementia care
Telehealth delivery of dementia care in the home can be as effective as face-to-face home visit services if carers and recipients take advantage of the technologies available, Australian researchers say.
Despite a marked reduction in the prevalence of dementia, the number of people with dementia is set to double by 2050 according to new Alzheimer Europe report
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe.
Inflammatory marker linked to dementia
Higher levels of an inflammatory marker, sCD14, were associated with brain atrophy, cognitive decline and dementia in two large heart studies.
How likely do you think you are to develop dementia?
A poll suggests almost half of adults ages 50 to 64 believe they're likely to develop dementia.
Latest issue of Alzheimer's & Dementia
Predicting heart disease might also be a warning sign for Alzheimer's; A new way to think about the environment and Alzheimer's research; Most dementia patients don't receive care from physicians who specialize in brain health.
What multilingual nuns can tell us about dementia
A strong ability in languages may help reduce the risk of developing dementia, says a new University of Waterloo study.
Brain changes may help track dementia, even before diagnosis
Even before a dementia diagnosis, people with mild cognitive impairment may have different changes in the brain depending on what type of dementia they have, according to a study published in the September 11, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Could marriage stave off dementia?
Dementia and marital status could be linked, according to a new Michigan State University study that found married people are less likely to experience dementia as they age.
Migraine diagnoses positively associated with all-cause dementia
Several studies have recently focused on the association between migraine headaches and other headaches and dementia and found a positive migraine-dementia relationship.
Apathy: The forgotten symptom of dementia
Apathy is the most common neuropsychiatric symptom of dementia, with a bigger impact on function than memory loss -- yet it is under-researched and often forgotten in care.
More Dementia News and Dementia Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Processing The Pandemic
Between the pandemic and America's reckoning with racism and police brutality, many of us are anxious, angry, and depressed. This hour, TED Fellow and writer Laurel Braitman helps us process it all.
Now Playing: Science for the People

#568 Poker Face Psychology
Anyone who's seen pop culture depictions of poker might think statistics and math is the only way to get ahead. But no, there's psychology too. Author Maria Konnikova took her Ph.D. in psychology to the poker table, and turned out to be good. So good, she went pro in poker, and learned all about her own biases on the way. We're talking about her new book "The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win".
Now Playing: Radiolab

Invisible Allies
As scientists have been scrambling to find new and better ways to treat covid-19, they've come across some unexpected allies. Invisible and primordial, these protectors have been with us all along. And they just might help us to better weather this viral storm. To kick things off, we travel through time from a homeless shelter to a military hospital, pondering the pandemic-fighting power of the sun. And then, we dive deep into the periodic table to look at how a simple element might actually be a microbe's biggest foe. This episode was reported by Simon Adler and Molly Webster, and produced by Annie McEwen and Pat Walters. Support Radiolab today at Radiolab.org/donate.