New efficacies of Ganoderma lucidum: Treatment of skin conditions like atopic dermatitis

October 07, 2020

Ganoderma lucidum, known as Yeongji mushroom in Korea, is called a modern-day elixir plant and has long been used medicinally in China, Japan and Korea. Ganoderic acid, an active ingredient found in the mushroom, is known for its excellence in enhancing the immune function of cells. Due to the hard texture of the mushroom, it has been ingested in powder or liquid form, but it has been noted that the active ingredient becomes destroyed when the mushroom is dried for an extended period of time or the extraction is performed at high heat (80 °C or higher).

The Korea Institute of Science and Technology (KIST) announced that a team led Dr. Ho-Youn Kim of the Smart Farm Research Center of the Gangneung Natural Products Informatics Center determined the conditions for enhancing the anti-inflammatory, anti-diabetic, and antioxidant effects of Ganoderma lucidum and confirmed its marketability as an anti-inflammatory agent for the skin.

In order to reduce the amount of the active ingredient destroyed and increase the efficacy, the KIST research team extracted the active ingredient after drying the mushroom at various temperatures and times, through which they pinpointed the optimal conditions to achieve the best possible anti-inflammatory, antioxidant and anti-diabetic effects. As a result, it was confirmed that drying with hot air at 60°C led to excellent anti-inflammatory properties, as it led to the extraction of a large amount of ganoderic acid, while outstanding antioxidant and antidiabetic activities resulted from freeze-drying the mushroom at -50°C.

Also, an experiment was carried out using the extract from hot air-dried Ganoderma lucidum on inflammation-induced keratinocytes, and the results showed that it effectively suppressed skin inflammation. The extraction conditions yielding such an effective active ingredient for skin inflammation have never been revealed before, and thus a patent application has been filed (Patent No.: 10-2020-0041577).

It is believed that the results of this study regarding the effect of varying the drying and extraction conditions on the antioxidant, antidiabetic, and anti-inflammatory activities of Ganoderma lucidum will be useful in developing processed products with the mushroom in the future.

Dr. Kim from KIST who spearheaded the research said, "Since the efficacy of Yeongji mushrooms (Ganoderma lucidum) varies depending on the drying and extraction methods, the drying method should be selected according to the purpose of use. It is expected that the findings of this study will not only raise the utility of the mushroom but also lead to the development of therapeutic agents for inflammatory skin conditions such as psoriasis and atopic dermatitis in the future."
This study was carried out with a grant from the Ministry of Science and ICT (MSIT), as part of the Institutional R&D Program of KIST. The paper was published in the latest issue of the international journal, Food Chemistry (IF: 6.306, Top 3.9% in the field of JCR).

National Research Council of Science & Technology

Related Atopic Dermatitis Articles from Brightsurf:

Diet affects skin gene expression in both healthy and atopic dogs
Differences in skin gene expression were observed between healthy and atopic Staffordshire Bull Terriers as well as between dogs that ate either dry food or raw food.

Some allergens that cause contact dermatitis are found in masks that prevent COVID-19
A medically challenging case presented at this year's virtual American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting revealed that for a man with several skin allergies, mask-wearing triggered his contact dermatitis.

Vitamin D lessens symptoms of severe eczema in children
Vitamin D supplementation eased the symptoms experienced by children with severe atopic dermatitis, or eczema, in a recent randomized controlled trial published in Pharmacology Research & Perspectives.

New efficacies of Ganoderma lucidum: Treatment of skin conditions like atopic dermatitis
Ganoderma lucidum, known as Yeongji mushroom in Korea, has long been used medicinally in China, Japan and Korea.

NIH-supported scientists demonstrate how genetic variations cause eczema
New research supported by the National Institutes of Health delineates how two relatively common variations in a gene called KIF3A are responsible for an impaired skin barrier that allows increased water loss from the skin, promoting the development of atopic dermatitis, commonly known as eczema.

No increased skin cancer risk with topical immunosuppressant ointments
Two topical immunosuppressant medications commonly prescribed to treat skin conditions do not appear to increase the risk for the most common forms of skin cancer, despite package label warnings to the contrary.

Mount Sinai researcher identifies single gene biomarker to differentiate between atopic dermatitis
Mount Sinai researchers have pinpointed a single gene biomarker, nitride oxide synthase 2 (NOS2) that can distinguish atopic dermatitis (AD) and psoriasis with 100 percent accuracy using adhesive tape strips, a non-invasive alternative to skin biopsy.

Biomedical researchers get closer to why eczema happens
A new study from researchers at Binghamton University, State University of New York may help to peel back the layers of unhealthy skin -- at least metaphorically speaking -- and get closer to a cure.

Researchers uncover novel approach for treating eczema
Researchers at the University of British Columbia (UBC) and Vancouver Coastal Health Research Institute (VCHRI) have identified a key enzyme that contributes to eczema, which may lead to better treatment to prevent the skin disorder's debilitating effects.

Tel Aviv University researchers discover receptor chain involved in atopic dermatitis
A new Tel Aviv University study identifies the precise receptor chain involved in the development of atopic dermatitis, the most common cause of eczema.

Read More: Atopic Dermatitis News and Atopic Dermatitis Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to