More evidence of benefits of REGN-COV2 antibody cocktail to both protect from and treat disease

October 09, 2020

In June, two studies in Science reported an antibody cocktail against SARS-CoV-2 developed from studies in humanized mice and recovering patients. The two antibody cocktail was designed to bind the virus to reduce the risk of a drug-resistant form emerging. Now, expanding upon this work, researchers show this antibody cocktail offers benefits in animal models that mimic the diverse pathology of SARS-CoV-2 infection, both when administered prophylactically and therapeutically. "These findings highlight the therapeutic potential of [this approach] to both protect from and treat SARS-CoV-2 disease," the authors say. While multiple studies have described discovery and characterization of potent neutralizing monoclonal antibodies against SARS-CoV-2, evaluation of the efficacy of these antibodies in vivo is limited, and it's largely focused on the prophylactic setting. As well, no single animal model has emerged as being more relevant for human disease, which has led some to say multiple animal models may be required to mimic various settings of human infection. Building on studies Johanna Hansen et al. and Alina Baum et al. published in Science in June that identified and characterized a double antibody therapy, Baum and colleagues tested this cocktail, REGN-COV2, in rhesus macaques, which manifest mild COVID-19 symptoms, and in golden hamsters, which show symptoms that are much more severe, including rapid weight loss. When administered three days before viral challenge, treatment almost completely blocked establishment of viral infection in macaques, the authors say. This ability, they note, "matches or exceeds the effects recently shown in vaccine efficacy studies using the same animal models." In macaques treated with the drug one day after infection, the authors report faster viral clearance than in controls who'd not been treated. Next, the authors used the hamster model to evaluate the drug's ability to alter the disease course in more severe cases. Hamsters treated with the drug two days before infection exhibited a "dramatic protection from weight loss" and decreased viral load in the lungs, the authors report. They also report benefits for hamsters treated one day after infection, as compared to controls. "In conclusion," say the authors, "our data provide evidence that REGN-COV2 based therapy may offer clinical benefit in both prevention and treatment settings of COVID-19 disease, where it is currently being evaluated."

American Association for the Advancement of Science

Related Weight Loss Articles from Brightsurf:

Weight loss shouldn't be the goal of PE
For adults, the goal of exercise is often to shed some pounds, but new research from the University of Georgia suggests the objective should be different for kids.

How long should you fast for weight loss?
Two daily fasting diets, also known as time-restricted feeding diets, are effective for weight loss, according to a new study.

Green tea may help with weight loss efforts
In an analysis published in Phytotherapy Research of randomized controlled trials, individuals who consumed green tea experienced a significant decline in body weight and body mass index.

Changing weight-loss strategies, attempts
The proportion of adults who tried to lose weight in the previous year increased from 1999 to 2016 but the findings of this observational study suggest the results may have been unsatisfactory.

Quality of life changes after weight loss
Obesity increases a number of adverse health consequences including reduced health-related quality of life.

Weight loss medicines underutilized by veterans
Despite the availability of new weight management medications and several clinical guidelines recommending their use as part of a comprehensive treatment plan for obesity, a new study has found that their use is extremely low (about one percent) among eligible Veterans.

Is the most effective weight-loss strategy really that hard?
Dietary self-monitoring is the best predictor of weight-loss success. But the practice is viewed as so unpleasant and time-consuming, many would-be weight-losers won't adopt it.

Study: Faster weight loss no better than slow weight loss for health benefits
Losing weight slowly or quickly won't tip the scale in your favor when it comes to overall health, according to new research.

Mindfulness training may help support weight loss
Mindfulness training may improve the effectiveness of intensive weight management programs, according to a small study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Does weight loss before surgery provide benefits?
For obese and overweight patients, it is common for various surgical procedures to be deferred until they have lost weight through diet and exercise.

Read More: Weight Loss News and Weight Loss Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to