Nav: Home

Common high blood pressure meds affect mood disorders

October 10, 2016

DALLAS, Oct. 10, 2016 - Four commonly prescribed blood pressure medications may impact mood disorders such as depression or bipolar disorder, according to new research in the American Heart Association's journal Hypertension.

In this first study, that compared four common classes of antihypertensive drugs and risk of mood disorders, two drugs were associated with an increased risk for mood disorders, while one appears to decrease mood disorder risk, according to Sandosh Padmanabhan, M.D., Ph.D., study author and Professor at the Institute of Cardiovascular and Medical Sciences, University of Glasgow in Glasgow, United Kingdom.

"Mental health is under-recognized in hypertension clinical practice, and the possible impact of antihypertensive drugs on mental health is an area that physicians should be aware of and consider if the treatment of high blood pressure is having a negative impact on their patient's mental health," Padmanabhan said.

Researchers collected data on 525,046 patients (ages 40-80) from two large secondary care Scottish hospitals. They selected 144,066 patients being treated for hypertension with either angiotensin antagonists, beta blocker, calcium channel blockers or thiazide diuretics. They were compared to a group of 111,936 patients not taking any of those drugs. Researchers followed the patients for five years documenting hospitalization for mood disorders, such as depression or bipolar disorder. After more than 90 days on the antihypertensive medications, they found:

There were 299 hospital admissions, predominantly due to major depression, among the patients studied, at an average 2.3 years after patients began antihypertensive treatment.

Patients on beta-blockers and calcium antagonists were at two-fold increased risk of hospital admission for mood disorder, compared to patients on angiotensin antagonists (angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers).

Patients on angiotensin antagonists had the lowest risk for hospitalization with mood disorders compared to patients on other blood pressure meds and patients on no antihypertensive therapy.

Patients taking thiazide diuretics showed the same risk for mood disorders compared to patients taking no antihypertensive meds.

The presence of co-existing medical conditions increased the risk of mood disorders.

These findings suggest that angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers that are used to treat hypertension may be useful as new or "repurposed" treatments for mood disorders, according to Padmanabhan.

"It is important that these results are validated in independent studies. This is a single center study, which looked at the risk of the more severe forms of mood disorders requiring hospitalization. It would be important to study the effect of these drugs on minor to modest changes in mood, as these will have an impact on the quality of life among hypertensive patients," he said.
-end-
Co-authors are Angela Boal, B.Sc.; Daniel Smith, M.D., F.R.C.Psych; Linsay McCallum, M.B.Ch.B.; Scott Muir, M.B.Ch.B.; Rhian Touyz, M.D., Ph.D. and Anna Dominiczak, M.D., F.R.C.P. Author disclosures are on the manuscript.

The Medical Research Council, British Heart Foundation, a Lister Institute Prize Fellowship and the Scottish Ecosystem for Precision Medicine supported the study.

Additional Resources:

Depression graphic and blood pressure and medication images are located in the right column of this release link http://newsroom.heart.org/news/common-high-blood-pressure-meds-affect-mood-disorders?preview=7ac8b15e533d729e12755d52978ffb57

Follow AHA/ASA news on Twitter @HeartNews
For the updates and new science from the Hypertension journal follow @HyperAHA

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.

American Heart Association

Related Depression Articles:

Tackling depression by changing the way you think
A thought is a thought. It does not reflect reality.
How depression can muddle thinking
Depression is associated with sadness, fatigue and a lack of motivation.
Neuroimaging categorizes 4 depression subtypes
Patients with depression can be categorized into four unique subtypes defined by distinct patterns of abnormal connectivity in the brain, according to new research from Weill Cornell Medicine.
Studies suggest inflammatory cytokines are associated with depression and psychosis, and that anti-cytokine treatment can reduce depression symptoms
Studies presented at this year's International Early Psychosis Association meeting in Milan, Italy, (Oct.
Is depression in parents, grandparents linked to grandchildren's depression?
Having both parents and grandparents with major depressive disorder was associated with higher risk of MDD for grandchildren, which could help identify those who may benefit from early intervention, according to a study published online by JAMA Psychiatry.
More Depression News and Depression Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Teaching For Better Humans
More than test scores or good grades — what do kids need to prepare them for the future? This hour, guest host Manoush Zomorodi and TED speakers explore how to help children grow into better humans, in and out of the classroom. Guests include educators Olympia Della Flora and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#535 Superior
Apologies for the delay getting this week's episode out! A technical glitch slowed us down, but all is once again well. This week, we look at the often troubling intertwining of science and race: its long history, its ability to persist even during periods of disrepute, and the current forms it takes as it resurfaces, leveraging the internet and nationalism to buoy itself. We speak with Angela Saini, independent journalist and author of the new book "Superior: The Return of Race Science", about where race science went and how it's coming back.