University of Guelph researcher develops 3-in-1 vaccine against traveller's diarrhea

October 10, 2018

A first-ever vaccine designed to deliver a one-two-three punch against the main causes of traveller's diarrhea worldwide may result from new research published by a University of Guelph chemist.

Prof. Mario Monteiro says his novel three-in-one approach to developing a new vaccine could also save lives in developing countries, where it's estimated that these three common pathogens kill more than 100,000 children under age five each year.

His research was recently published in the journal Vaccine.

The paper discusses Monteiro's so-called conjugate vaccine that yokes together proteins from pathogenic E. coli with sugars from Shigella and Campylobacter jejuni. All three bugs are major causes of bacterial diarrhea globally.

In tests with mice, the vaccine provided immunity against all three pathogens.

No licensed vaccines exist against any of these pathogens. A sugar-based vaccine developed by Monteiro in 2009 against campylobacter alone is currently undergoing human trials but is still an estimated decade away from potential release.

He said this new three-in-one approach may ultimately overtake that earlier single-target vaccine, although any new vaccine may take decades to test and release. "We're targeting three pathogens at the same time," he said. "Instead of three shots, maybe you only need one."

As with the earlier campylobacter vaccine, this new method has been patented by U of G and the United States Naval Medical Research Center, which funded the research.

Monteiro said further research is needed to determine the optimum amounts of protein and sugars in the vaccine and to make the vaccine more efficient.

He worked on the project with former post-doc Zuchao Ma and former graduate students Brittany Pequegnat and Eman Omari, along with U.S. navy researchers.
-end-
Find study here.

University of Guelph

Related Pathogens Articles from Brightsurf:

Pathogens in the mouth induce oral cancer
Pathogens found in tissues that surround the teeth contribute to a highly aggressive type of oral cancer, according to a study published 1st October in the open-access journal PLOS Pathogens by Yvonne Kapila of the University of California, San Francisco, and colleagues.

A titanate nanowire mask that can eliminate pathogens
Researchers in Lásló Forró's lab at EPFL, Switzerland, are working on a membrane made of titanium oxide nanowires, similar in appearance to filter paper but with antibacterial and antiviral properties.

Plastics, pathogens and baby formula: What's in your shellfish?
The first landmark study using next-generation technology to comprehensively examine contaminants in oysters in Myanmar reveals alarming findings: the widespread presence of human bacterial pathogens and human-derived microdebris materials, including plastics, kerosene, paint, talc and milk supplement powders.

The Parkinson's disease gut has an overabundance of opportunistic pathogens
In 2003, Heiko Braak proposed that Parkinson's disease is caused by a pathogen in the gut that could pass through the intestinal mucosal barrier and spread to the brain through the nervous system.

Crop pathogens 'remarkably adaptable'
Pathogens that attack agricultural crops show remarkable adaptability to new climates and new plant hosts, new research shows.

Inexpensive, portable detector identifies pathogens in minutes
Most viral test kits rely on labor- and time-intensive laboratory preparation and analysis techniques; for example, tests for the novel coronavirus can take days to detect the virus from nasal swabs.

Outsmarting pathogens
A new influenza strain appears each flu season, rendering past vaccines ineffective.

Autonomous microtrap for pathogens
Antibiotics are more efficient when they can act on their target directly at the site of infestation, without dilution.

Acidic environment could boost power of harmful pathogens
New findings published in PLOS Pathogens suggest lower pH in the digestive tract may make some bacterial pathogens even more dangerous.

Protozoans and pathogens make for an infectious mix
The new observation that strains of V. cholerae can be expelled into the environment after being ingested by protozoa, and that these bacteria are then primed for colonisation and infection in humans, could help explain why cholera is so persistent in aquatic environments.

Read More: Pathogens News and Pathogens Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.