Economic advantage to pediatric ondansetron administration in emergency departments

October 12, 2010

In research published this week in PLoS Medicine, Stephen Freedman (University of Toronto) and colleagues performed a cost analysis of the emergency department administration of oral ondansetron to children with dehydration and vomiting secondary to gastroenteritis and found that this treatment could provide substantial economic, as well as clinical, benefit.

The researchers analyzed the costs of the administration of oral ondansetron in both the US and Canada, if routinely given to children with gastroenteritis-induced vomiting and dehydration in the emergency department setting and found that in the US and Canada the use of ondansetraon would provide substantial reductions in financial costs. hospitalizations and intravenous insertions.

They conclude that in countries where intravenous rehydration is often employed, the emergency department administration of oral ondansetron to children with dehydration and vomiting secondary to gastroenteritis is likely to be valuable. However, in less developed countries the emphasis for treatment of children with dehydration and vomiting should remain on oral rehydration therapy alone.
-end-
Funding: No direct funding was received for this study. The authors were personally salaried by their institutions during the period of writing though no specific salary was set aside or given for the writing of this paper. No funding bodies had any role in the study design, data collection, analysis, decision to publish or preparation of the manuscript.

Competing Interests: All authors declare that SF, MS, KC have no relationships with GlaxoSmithKline that might have an interest in the submitted work in the previous 3 years; their spouses, partners, or children have no financial relationships that may be relevant to the submitted work; and SF, MS, KC have no nonfinancial interests that may be relevant to the submitted work. SBF does acknowledge that he received research support from GlaxoSmithKline in 2003 but has not had any relationship with them since. He currently receives research support from Institut Rosell Lallemand. KJC previously received research support from GlaxoSmithKline (2000) but has not had any relationship with them since.

Citation: Freedman SB, Steiner MJ, Chan KJ (2010) Oral Ondansetron Administration in Emergency Departments to Children with Gastroenteritis: An Economic Analysis. PLoS Med 7(10): e1000350. doi:10.1371/journal.pmed.1000350

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000350

PRESS-ONLY PREVIEW OF THE ARTICLE: www.plos.org/press/plme-07-10-freedman.pdf

CONTACT:

Stephen Freedman
University of Toronto
Paediatrics
The Hospital for Sick Children
555 University Avenue
Toronto, ON M5G 1X8
Canada
416-813-7654 ext 2382
stephen.freedman@sickkids.ca

PLOS

Related Children Articles from Brightsurf:

Black and Hispanic children in the US have more severe eczema than white children
A presentation at this year's virtual American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting reveals the disparities that exist for Black and Hispanic children when it comes to Atopic Dermatitis (AD), commonly known as eczema.

Black children with cancer three times less likely to receive proton radiotherapy than White children
A retrospective analysis led by investigators from Brigham and Women's Hospital has found racial disparities in the use of the therapy for patients enrolled in trials.

The Lancet Child & Adolescent Health: First Europe-wide study of children confirms COVID-19 predominately causes mild disease in children and fatalities are very rare
Children with COVID-19 generally experience a mild disease and fatalities are very rare, according to a study of 582 patients from across Europe published today in The Lancet Child & Adolescent Health journal.

Children not immune to coronavirus; new study from pandemic epicenter describes severe COVID-19 response in children
- While most children infected with the novel coronavirus have mild symptoms, a subset requires hospitalization and a small number require intensive care.

How many children is enough?
Most Russians would like to have two children: a boy and a girl.

Preterm children have similar temperament to children who were institutionally deprived
A child's temperament is affected by the early stages of their life.

Only-children more likely to be obese than children with siblings
Families with multiple children tend to make more healthy eating decisions than families with a single child.

Children living in countryside outperform children living in metropolitan area in motor skills
Residential density is related to children's motor skills, engagement in outdoor play and organised sports. that Finnish children living in the countryside spent more time outdoors and had better motor skills than their age peers in the metropolitan area.

Hispanic and black children more likely to miss school due to eczema than white children
In a study that highlights racial disparities in the everyday impact of eczema, new research shows Hispanic and black children are more likely than white children to miss school due to the chronic skin disease.

Children, their parents, and health professionals often underestimate children's higher weight status
More than half of parents underestimated their children's classification as overweight or obese -- children themselves and health professionals also share this misperception, according to new research being presented at this year's European Congress on Obesity (ECO) in Glasgow, UK (April 28-May 1).

Read More: Children News and Children Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.