Nav: Home

Study finds cold therapy may be effective at controlling cancer treatment side effects

October 12, 2017

A new study published in the Journal of the National Cancer Institute finds that cryotherapy, specifically having chemotherapy patients wear frozen gloves and socks for 90-minute periods, is useful for preventing symptoms of neuropathy.

Chemotherapy-induced peripheral neuropathy is a frequent and disabling side effect of cancer treatment. The pain, numbness, and tingling that patients experience reduces their quality of life and often results in them delaying treatment, reducing their doses, or discontinuing treatment altogether. Duloxetine is recommended treatment for the neuropathy; however, it has limited efficacy for the amelioration of chemotherapyinduced pain, and none for numbness or functional disability. Furthermore, no established strategy exists for neuropathy prevention in patients being treated with chemotherapy.

Researchers prospectively evaluated the efficacy of cryotherapy for neuropathy prevention. Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on one side of their bodies for 90 minutes, including the entire duration of drug infusion. Researchers compared symptoms on the treated sides with those on the untreated sides. The primary end point was neuropathy incidence assessed by changes in tactile sensitivity from a pretreatment baseline. Researchers also assessed subjective symptoms (as reported in a patient questionnaire) and patients' manual dexterity.

Among the 40 patients, four did not reach the cumulative dose (due to the occurrence of pneumonia, severe fatigue, liver dysfunction, and macular edema), leaving 36 patients for analysis. None dropped out due to cold intolerance. The incidence of objective and subjective neuropathy signs was clinically and statistically significantly lower on the intervention side than on the control side for all measurements.

Researchers report that their study supports the efficacy of cryotherapy for chemotherapy-induced peripheral neuropathy prevention, as evidenced by a clinically and statistically significant reduction in patient-reported subjective symptoms, diminished objective signs (tactile and thermosensory), and prevention of reduced manual dexterity. The development of subjective neuropathy symptoms was clinically and statistically significantly delayed during the course of the paclitaxel treatment, the occurrence of subjective neuropathy at a cumulative dose of 960 mg/m2 was almost completely prevented, and the neuropathy incidence tended to be lower on the intervention side.

The results of the study suggest that that cyrotherapy could be an effective strategy for the prevention of neuropathy in patients with cancer undergoing paclitaxel treatment. Cyrotherapy could support the delivery of optimal chemotherapy by preventing a dose delay or reduction, as well as inhibiting the deterioration of quality of life in cancer patients during and after treatment.

"If the results are confirmed, cryotherapy has the advantage of a limited side effect profile, is low-cost, and it appears to prevent components of neuropathy other than [just] neuropathic pain," wrote Dawn Hershman, MD, leader of the breast cancer program of the Herbert Irving Comprehensive Cancer Center at Columbia University, in an editorial the accompanied the study. "Ultimately a better understanding of the biologic mechanisms causing chemotherapy-induced peripheral neuropathy will improve our ability to effectively prevent and treat all components of this toxicity."
-end-
The paper "Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: 5 Prospective Self-Controlled Trial" is available at: https://academic.oup.com/jnci/article/doi/10.1093/jnci/djx178/4443215/Effects-of-Cryotherapy-on-Objective-and-Subjective

Direct correspondence to:

Hiroshi Ishiguro, MD, PhD, FACP
Department of Medical Oncology
International University of Health and Welfare Hospital
537-3 Iguchi,
Nasushiobara, Tochigi, 329-2763, JAPAN
e-mail: hishiguro@iuhw.ac.jp

To request a copy of the study, please contact:

Daniel Luzer
daniel.luzer@oup.com

Sharing on social media? Find Oxford Journals online at @OxfordJournals

Oxford University Press USA

Related Pain Articles:

Spinal manipulation treatment for low back pain associated with modest improvement in pain, function
Among patients with acute low back pain, spinal manipulation therapy was associated with modest improvements in pain and function at up to six weeks, with temporary minor musculoskeletal harms, according to a study published by JAMA.
Pain in the neck
Researchers led by University of Utah bioengineering assistant professor Robby Bowles have discovered a way to curb chronic pain by modulating genes that reduce tissue- and cell-damaging inflammation.
Can staying active help to prevent chronic pain? Physical activity affects pain modulation in older adults
Older adults with higher levels of physical activity have pain modulation patterns that might help lower their risk of developing chronic pain, reports a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP).
Is back pain killing us?
Older people who suffer from back pain have a 13 per cent increased risk of dying from any cause, University of Sydney research has found.
Improving pain care through implementation of the Stepped Care Model for Pain Management
A new study published in the Journal of Pain Research provides evidence that implementation of a Stepped Care Model for Pain Management has the potential to more adequately treat chronic pain.
Surgery for back pain reduces problems with sex life-related pain
For patients with degenerative spinal disease, surgery is more effective in reducing pain that interferes with sexual activity, compared to nonsurgical treatment, reports a study in the Nov.
'Pain paradox' discovery provides route to new pain control drugs
A natural substance known to activate pain in the central nervous system has been found to have the opposite effect in other parts of the body, potentially paving the way to new methods of pain control.
Treating pain without feeding addiction: Study shows promise of non-drug pain management
A new study shows the potential for patients who have both addiction issues and chronic pain to get relief from an approach that combines behavioral therapy and social support to help them manage their pain without painkillers that carry an addiction risk.
Neuropathic pain unmasks subliminal excitation in pain processing circuits
Research by Steven Prescott, at Toronto's Hospital for Sick Children, sheds new light on the mechanism underlying the establishment of neuropathic pain.
The anatomy of pain
Emotions consist of general components that are also elicited by similar impressions and specific components.

Related Pain Reading:

Healing Back Pain: The Mind-Body Connection
by John E. Sarno (Author)

Dr. John E. Sarno is a medical pioneer whose program has helped thousands upon thousands of people overcome their back conditions--without or drugs or dangerous surgery. Now, using his groundbreaking research into TMS (Tension Myositis Syndrome), Dr. Sarno goes one step further: after identifying stress and other psychological factors in back pain, he demonstrates how many of his patients have gone on to heal themselves without exercise or other physical therapy. Find out: Why self-motivated and successful people are prone to TMS; How anxiety and repressed anger trigger muscle spasms; How... View Details


Pain Free: A Revolutionary Method for Stopping Chronic Pain
by Pete Egoscue (Author), Roger Gittines (Author)

Starting today, you don't have to live in pain.

That is the revolutionary message of this breakthrough system for eliminating chronic pain without drugs, surgery, or expensive physical therapy. Developed by Pete Egoscue, a nationally renowned physiologist and sports injury consultant to some of today's top athletes, the Egoscue Method has an astounding 95 percent success rate. The key is a series of gentle exercises and carefully constructed stretches called E-cises. Inside you'll find detailed photographs and step-by-step instructions for dozens of e-cizes specifically designed to... View Details


Pain: A Political History
by Keith Wailoo (Author)

In this history of American political culture, Keith Wailoo examines how pain has defined the line between liberals and conservatives from just after World War II to the present. From disabling pain to end-of-life pain to fetal pain, the battle over whose pain is real and who deserves relief has created stark ideological divisions at the bedside, in politics, and in the courts.

Beginning with the return of soldiers after World War II and fierce medical and political disagreements about whether pain constitutes a true disability, Wailoo explores the 1960s rise of an expansive liberal... View Details


Heal Pelvic Pain: The Proven Stretching, Strengthening, and Nutrition Program for Relieving Pain, Incontinence,& I.B.S, and Other Symptoms Without Surgery
by Amy Stein (Author)

Bronze Medal Winner of a 2009 National Health Information Award

Stop your pelvic pain . . . naturally!

If you suffer from an agonizing and emotionally stressful pelvic floor disorder, including pelvic pain, irritable bowel syndrome, endometriosis, prostatitis, incontinence, or discomfort during sex, urination, or bowel movements, it's time to alleviate your symptoms and start healing--without drugs or surgery. Natural cures, in the form of exercise, nutrition, massage, and self-care therapy, focus on the underlying cause of your pain, heal your condition, and stop... View Details


The Problem of Pain
by C. S. Lewis (Author)

In The Problem of Pain, C.S. Lewis, one of the most renowned Christian authors and thinkers, examines a universally applicable question within the human condition: “If God is good and all-powerful, why does he allow his creatures to suffer pain?” With his signature wealth of compassion and insight, C.S. Lewis offers answers to these crucial questions and shares his hope and wisdom to help heal a world hungering for a true understanding of human nature.

View Details


Explain Pain (8311)
by David Butler (Author)

Explain Pain is a proven stayer among health texts. With great clarity and quirky images, it answers common questions asked by pain sufferers, such as "Why am I in pain?", "Why has it spread?" and "What can I do to help?"

Explain Pain gives new and immediate hope to pain sufferers and their family and friends. It describes the complexities of the central nervous system for chronic pain patients in everyday language. Studies now show that understanding more about why things hurt can help patients go about their daily lives. This book aims to empower clinicians and pain sufferers to... View Details


Walking with God through Pain and Suffering
by Timothy Keller (Author)

From the New York Times bestselling author of the forthcoming God's Wisdom for Navigating Life Timothy Keller comes the definitive Christian book on why bad things happen and how we should respond to them.

The question of why God would allow pain and suffering in the world has vexed believers and nonbelievers for millennia. Timothy Keller, whose books have sold millions of copies to both religious and secular readers, takes on this enduring issue and shows that there is meaning and reason behind our pain and suffering, making a forceful and ground-breaking case... View Details


8 Steps to a Pain-Free Back: Natural Posture Solutions for Pain in the Back, Neck, Shoulder, Hip, Knee, and Foot
by Esther Gokhale (Author), Susan Adams (Editor)

Nearly 90% of American adults suffer from back pain, and the number continues to climb. Why does this condition affect so many people in the industrialized world, while in some countries only 5% of adults report back pain? In a quest to find the root cause of back pain, Esther Gokhale studied at the Aplomb Institute in Paris and traveled to parts of the world where back pain is virtually unknown. Her research took her to remote Burkina Faso, rural Portugal, and fishing villages in Brazil.

What she learned in each of these places has changed the lives of thousands of people.... View Details


Gift of Pain, The
by Paul Brand (Author), Philip Yancey (Author)

A WORLD WITHOUT PAIN?Can such a place exist? It not only can―it does. But it’s no utopia. It’s a colony for leprosy patients: a world where people literally feel no pain, and reap horrifying consequences.His work with leprosy patients in India and the United States convinced Dr. Paul Brand that pain truly is one of God’s great gifts to us. In this inspiring story of his fifty-year career as a healer, Dr. Brand probes the mystery of pain and reveals its importance. As an indicator that lets us know something is wrong, pain has a value that becomes clearest in its absence.The Gift of... View Details


The Explain Pain Handbook Protectometer (8315)
by GL Moseley (Author), David Butler (Author)

The Explain Pain Handbook: Protectometer is a new collaboration between Professor Lorimer Moseley and Dr. David Butler. Based on the most up-to-date research and the Explain Pain book, it allows patients experiencing pain to explore their unique pain story. The centrepiece of the handbook the ProtectometerTM is an interactive device that allows patients and therapists to gain a deeper understanding of the experience and establish an individualized treatment and education plan. View Details

Best Science Podcasts 2017

We have hand picked the best science podcasts for 2017. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Manipulation
We think we're the ones who control what we see, read, think and remember. But is that true? Who decides? And who should decide? This hour, TED speakers reveal just how easily we can be manipulated. Guests include design ethicist Tristan Harris, MSNBC host Ali Velshi, psychologist Elizabeth Loftus, and neuroscientist Steve Ramirez.
Now Playing: Science for the People

#444 The V-Word (Rebroadcast)
This week, we're looking at the social and biological science of female sex organs. We'll talk to Dr. Anthony Atala, director of the Wake Forest Baptist Medical Center Institute for Regenerative Medicine, about the creation and use of lab-grown vaginas. Biology professor Marie Herberstein exposes the bias against female genitalia in scientific studies. And science writer Emily Anthes tells us about the history and promising future of female condoms.