Does hypertriglyceridemia aggravate the episodes of severe acute pancreatitis?

October 13, 2008

HTG is a common clinical problem but rare cause of pancreatitis. It was reported that HTG is independently associated with the severity of AP and plays a role in the aggravation of acute necrotizing pancreatitis patients. However, the role of HTG in modulating disease course of

A research article to be published on July 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Xia from West China Hospital of Sichuan University investigated the effect of admission HTG on the episodes of SAP.

In this study, one hundred and seventy-six patients with SAP were divided into HTG group (n = 45) and control group (n = 131) according to admission triglyceride (TG) ≥ 5.65 mmol/L and < 5.65 mmol/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson' s score, acute physiology and chronic heath evaluation II(APACHE II) score, Balthazar's computed tomography (CT) score, complications and mortality werecompared. Correlation between admission TG and 24-hour APACHEⅡscore was analyzed.

Their results show that the incidence of admission hypocalcaemia, a predictable index of SAP, and the 24 hour APACHE II score were higher in the HTG group than in the control group. The complications, such as renal failure, shock and infection, and the mortality were higher in the HTG group than in the control group, indicating that HTG aggravates SAP, leading to systemic complications and a high mortality rate of SAP.
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Reference: Deng LH, Xue P, Xia Q, Yang XN, Wan MH. Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis. World J Gastroenterol 2008; 14(28):4558-4561 http://www.wjgnet.com/1007-9327/14/4558.asp

Correspondence to: Professor Qing Xia, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. xiaqing@medmail.com.cn Telephone: +86-28-85423373 Fax: +86-28-85423028

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

About The WJG Press

The WJG Press mainly publishes World Journal of Gastroenterology.

World Journal of Gastroenterology

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