New HIV guidelines support use of FUZEON® + active boosted PI for treatment-experienced patients

October 14, 2005

Basel (CH), 14 October 2005. The importance of the drug FUZEON® (enfuvirtide) in the management of HIV has been officially recognised by the US Department of Health and Human Services (DHHS). Their newly updated HIV/AIDS treatment guidelines support the use of FUZEON with an active boosted protease inhibitor (PI) for the management of treatment-experienced patients.

"These guidelines clearly set more ambitious goals for the management of treatment-experienced patients now that we have potent therapies such as the combination of tipranavir and enfuvirtide," commented Dr Anton Pozniak, Chelsea and Westminster Hospital, London. "These guidelines provide real clarity and much needed direction on how to best care for pre-treated patients."

The DHHS recommendation reflects the growing body of evidence for the powerful "FUZEON effect" which has been seen across the RESIST 1 & 2, POWER 1 & 2 and TORO 1 & 2 studies. These studies showed that adding FUZEON almost doubled the number of patients reaching undetectable, when combined with one of the latest boosted protease inhibitors (PI) such as lopinavir, tipranavir or TMC 114.

The guidelines recommend the treatment goal of achieving the suppression of the virus to levels that make it undetectable in the blood, for treatment-experienced patients who show some drug resistance but still have some active antiretroviral agents available. An active drug is one that is still effective against the virus.
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Notes to Editors:

Recommendations -The updated DHHS guidelines (October 6, 2005) are available online: http://aidsinfo.nih.gov/guidelines/.

The Panel on Clinical Practices for Treatment of HIV Infection of the US Department of Health and Human Services (DHHS) focuses on the overall management of treatment-experienced patients. It also provides guidance on changing an antiretroviral therapy regimen for virologic failure, for which the latest recommendations include: Growing Body of Evidence, RESIST 1&2 / POWER 1 & 2/ TORO 1& 2 - Collectively the data from all six studies, in over 2,500 patients, establish a new paradigm in the management of triple class-experienced patients. Latest data adds to growing Body of Evidence - Latest Boosted Protease Inhibitors (lopinavir/r, tipranavir/r and TMC 114/r) all work best in combination with FUZEON.

RESIST Phase III tipranavir trials
POWER Phase II TMC114 dosing trials
TORO Phase III FUZEON trials
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