Exposure to atomic bomb radiation associated with nervous system tumors

October 15, 2002

A study of the effects of radiation exposure among Japanese atomic bomb survivors has found that exposure to even moderate doses of radiation is associated with an increased incidence of nervous system tumors. The finding appears in the October 16 issue of the Journal of the National Cancer Institute.

What causes brain and nervous system tumors is not entirely clear. Some epidemiologic studies have suggested that an increased risk of certain nervous system tumors is associated with high-dose radiation treatment, especially among patients who received treatment as children. Other studies have suggested that atomic bomb radiation exposure is associated with an increased risk of certain nervous system tumors.

To measure the impact of radiation exposure on the incidence of nervous system tumors, Dale L. Preston, Ph.D., of the Radiation Effects Research Foundation in Hiroshima, Japan, and his colleagues used information from tumor registries, medical records, and death certificates to identify benign and malignant tumors of the primary nervous system and pituitary gland that were diagnosed between 1958 and 1995 in 80,160 Japanese atomic bomb survivors. Study pathologists reviewed the records to confirm the diagnoses.

The authors found that radiation exposure was associated with an increased risk of all nervous system tumors combined. This risk was particularly high for schwannomas, a benign tumor of the nervous system. Further analysis revealed that men had a higher risk of nervous system tumors than women, and people exposed to radiation as children had a higher risk than those exposed as adults.

Although additional follow-up is needed, the authors say their findings "demonstrate that radiation exposure can increase the risk of nervous system tumors and suggest that these increased risks persist throughout lifetime, regardless of the age at exposure."
-end-
Contact: Dale Preston, Radiation Effects Research Foundation, 81-82-261-7219 (8 p.m. to 4 a.m. EDT), 81-82-242-6041 (6 a.m. to 11 a.m. EDT), preston@rerf.or.jp

Preston D, Ron E, Yonehara S, Kobuke T, Fujii H, Kishikawa M, et al. Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure. J Natl Cancer Inst 2002;94:1555-63.

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage.

Journal of the National Cancer Institute

Related Nervous System Articles from Brightsurf:

Chikungunya may affect central nervous system as well as joints and lungs
Investigation conducted by international group of researchers showed that chikungunya virus can cause neurological infections.

Glial cells play an active role in the nervous system
Researchers at M√ľnster University, Germany, have discovered that glial cells - one of the main components of the brain -not only control the speed of nerve conduction, but also influence the precision of signal transduction in the brain.

Protein produced by the nervous system may help treatments for inflammatory diseases
A Rutgers-led team discover a protein produced by nervous system may be key to treating inflammatory diseases like asthma, allergies, chronic fibrosis and chronic obstructive pulmonary disease (COPD)

COVID-19 may attack patients' central nervous system
''There may be more central nervous system penetration of the virus than we think based on the prevalence of olfaction-associated depressed mood and anxiety and this really opens up doors for future investigations to look at how the virus may interact with the central nervous system,'' explains Ahmad Sedaghat, MD, PhD.

Lifting weights makes your nervous system stronger, too
Gym-goers may get frustrated when they don't see results from weightlifting right away, but their efforts are not in vain: the first few weeks of training strengthen the nervous system, not muscles.

COVID-19 threatens the entire nervous system
A new review of neurological symptoms of COVID-19 patients in current scientific literature reveals the disease poses a global threat to the entire nervous system.

Fewer scars in the central nervous system
Researchers have discovered the influence of the coagulation factor fibrinogen on the damaged brain.

Polymerized estrogen shown to protect nervous system cells
In research published today in Nature Communications, an interdisciplinary team from Rensselaer Polytechnic Institute demonstrated how estrogen -- a natural hormone produced in the body -- can be polymerized into a slow-releasing biomaterial and applied to nervous system cells to protect those cells and even promote regeneration.

Discovery concerning the nervous system overturns a previous theory
It appears that when our nervous system is developing, only the most viable neurons survive, while immature neurons are weeded out and die.

Autonomic nervous system appears to function well regardless of mode of childbirth
'In a low-risk group of babies born full-term, the autonomic nervous system and cortical systems appear to function well regardless of whether infants were exposed to labor prior to birth,' says Sarah B.

Read More: Nervous System News and Nervous System Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.