Xenotropic murine leukemia virus-related virus may not be associated with human prostate cancer

October 15, 2009

The xenotropic murine leukemia virus-related virus (XMRV) which has previously been linked to prostate cancer has been found to have a dramatically lower prevalence among German prostate cancer patients, if any. Contrary to some reports, which have found XMRV in 40% of cases in patients in the US with familial prostate cancer, research published today in BioMed Central's open access journal, Retrovirology has found no link between the two conditions in a large study of German prostate cancer patients.

The experimental research was undertaken by a team from the Robert Koch Institute and the Charité in Berlin, Germany, led by Norbert Bannert and Reinhard Kurth. They used real-time PCR and nested PCR techniques to genotype the RNase L gene (an interferon regulated antiviral defence gene) and detect the presence of the XMRV virus in samples collected from 589 prostate cancer patients between the years 2000 and 2006. Some samples were also tested for the presence of Env antibodies directed against XMRV using an ELISA.

Knowledge relating to the genetic susceptibility and risk factors of prostate cancer increase the likelihood of early detection and successful treatment of the disease. Previously, the HPC1 locus (hereditary prostate cancer locus-1) has been identified as a hereditary factor associated with a predisposition to prostate cancer. The gene RNaseL is found within this locus. The RNase L gene codes for an endoribonuclease that is involved in the interferon-regulated antiviral defence pathway. Certain polymophisms in this gene in which the enzyme product has reduced activity have been reported by others as being linked to increased risk of prostate cancer (presumptively due to XMRV-infection) in the US and Japan.

In the current study, from the 589 prostate tumor samples, 76 were found to be homozygous for the previously reported RNase L presumptively XMRV-susceptible Q (R462Q) genotype, however, neither DNA nor RNA fragments of XMRV were detected in samples collected from the prostate cancers. ELISA results show that none of the patients had antibodies directed against XMRV, suggesting that in German prostate cancer patients at least, there is no evidence for XMRV infection or XMRV-linked prostate cancer even in individuals with the RNase L XMRV-susceptible Q genotype. According to Bannert, "a possible geographical restriction of XMRV and its associations with cases of prostate cancer should be studied closely", adding that "the oncogenic potential of the virus must be thoroughly investigated in order to establish whether or not it can trigger the development of prostate cancer."
-end-
Notes to Editors

1. Article:

Lack of evidence for xenotropic murine leukemia virus-related virus (XMRV) in German prostate cancer patients
Oliver Hohn, Hans Krause, Pia Barbarotto, Lars Niederstadt, Nadine Beimforde, Joachim Denner, Kurt Miller, Reinhard Kurth and Norbert Bannert
Retrovirology (in press)

During the embargo, article available here: http://www.retrovirology.com/imedia/5628949702874654_article.pdf?random=660160

After embargo, article available at the journal website: http://www.retrovirology.com/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

2. Retrovirology is a stringently peer-reviewed journal edited by Kuan-Teh Jeang (USA), Monsef Benkirane (France), Ben Berkhout (the Netherlands), Masahiro Fujii (Japan), Michael Lairmore (USA), Andrew Lever (UK), and Mark Wainberg (Canada) with the assistance of an internationally renowned Editorial Board. Retrovirology has an Impact Factor of 4.04. Read all the latest news from Retrovirology, on the Retrovirology blog

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

BioMed Central

Related Prostate Cancer Articles from Brightsurf:

Low risk of cancer spread on active surveillance for early prostate cancer
Men undergoing active surveillance for prostate cancer have very low rates - one percent or less - of cancer spread (metastases) or death from prostate cancer, according to a recent study published in the Journal of Urology®, an Official Journal of the American Urological Association (AUA).

ESMO 2020: Breast cancer drug set to transform prostate cancer treatment
A drug used to treat breast and ovarian cancer can extend the lives of some men with prostate cancer and should become a new standard treatment for the disease, concludes a major trial which is set to change clinical practice.

Major trial shows breast cancer drug can hit prostate cancer Achilles heel
A drug already licensed for the treatment of breast and ovarian cancers is more effective than targeted hormone therapy at keeping cancer in check in some men with advanced prostate cancer, a major clinical trial reports.

The Lancet: Prostate cancer study finds molecular imaging could transform management of patients with aggressive cancer
Results from a randomised controlled trial involving 300 prostate cancer patients find that a molecular imaging technique is more accurate than conventional medical imaging and recommends the scans be introduced into routine clinical practice.

Common genetic defect in prostate cancer inspires path to new anti-cancer drugs
Researchers found that, in prostate cancer, a mutation leading to the loss of one allele of a tumor suppressor gene known as PPP2R2A is enough to worsen a tumor caused by other mutations.

First prostate cancer therapy to target genes delays cancer progression
For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large phase 3 trial.

Men taking medications for enlarged prostate face delays in prostate cancer diagnosis
University of California San Diego School of Medicine researchers report that men treated with medications for benign prostatic hyperplasia (enlarged prostate) experienced a two-year delay in diagnosis of their prostate cancer and were twice as likely to have advanced disease upon diagnosis.

CNIO researchers confirm links between aggressive prostate cancer and hereditary breast cancer
The study has potential implications for families with members suffering from these types of tumours who are at an increased risk of developing cancer.

Distinguishing fatal prostate cancer from 'manageable' cancer now possible
Scientists at the University of York have found a way of distinguishing between fatal prostate cancer and manageable cancer, which could reduce unnecessary surgeries and radiotherapy.

Researchers find prostate cancer drug byproduct can fuel cancer cells
A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic.

Read More: Prostate Cancer News and Prostate Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.