Golden meat: Engineering cow cells to produce beta carotene

October 15, 2020

A group of researchers at Tufts University have genetically engineered cow muscle cells to produce plant nutrients not natively found in beef cells. Using the same carotenoid pathway exploited in golden rice, they coaxed bovine cells into producing beta carotene—a provitamin usually found in carrots and tomatoes.

In doing so, they demonstrated that cell-cultured meat might be able to surpass the nutritional profile of conventionally farmed meat.

"Cows don't have any of the genes for producing beta carotene," said Andrew Stout, lead author of the study and Biomedical Engineering PhD student at Tufts University. "We engineered cow muscle cells to produce this and other phytonutrients, which in turn allows us to impart those nutritional benefits directly onto a cultured meat product in a way that is likely infeasible through animal transgenics and conventional meat production."

These findings, published in the journal Metabolic Engineering, are proof of principle for using genetic engineering and cellular agriculture to create novel foods. Rather than simply mimicking meat currently found in the grocery store, cell-cultured meat products are capable of assuming different shapes, textures, nutritional profiles, and bioactivities.

One such feature is carcinogenicity, or rather, the lack thereof.

"We saw a reduction in lipid oxidation levels when we cooked a small pellet of these cells when they were expressing and producing this beta carotene," said Stout. "Because that lipid oxidation is one of the key mechanistic proposals for red and processed meats' link to diseases such as colorectal cancer, I think that there is a pretty compelling argument to be made that this could potentially reduce that risk."

Nutritionally enhancing cultured meat products might give the burgeoning cellular agriculture industry the leg up it needs to compete with conventional meat. Although cultured meat producers have exponentially lowered the cost of production over the last few years, the technology faces an uphill battle in competing with a heavily subsidized status quo.

"It will likely be challenging for cultured meat to be competitively competitively priced with factory farmed meat right out of the gate," said David Kaplan, Stern Family Professor of Engineering at the Tufts University School of Engineering and corresponding author of the study. "A value-added product which provides consumers with added health benefits may make them more willing to pay for a cultured meat product."
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Other authors contributing to the study include Addison B. Mirliani, Erin L. Soule-Albridge, and Julian M. Cohen. The full paper can be found here: https://doi.org/10.1016/j.ymben.2020.07.011

This work was supported by the New Harvest Graduate Fellowship Program, the National Institutes of Health (P41EB002520), and the National Institutes of Health Research Infrastructure grant (S10 OD021624). The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health.

About New Harvest:

New Harvest is a nonprofit research institute that funds and conducts open, public cultured meat research. Established in 2004, New Harvest is the world's oldest research institute dedicated exclusively to cellular agriculture. Its targeted, people-focused funding is designed to foster technical leadership, build scientific infrastructure, and address knowledge gaps. New Harvest's mission to maximize the positive impact of cellular agriculture, ensuring that the burgeoning industry delivers on its promises to reduce our dependence on animal agriculture and the heavy toll of protein production on the environment and public health.

For more information, please visit https://www.new-harvest.org/

New Harvest

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