Reelin-Nrp1 interaction regulates neocortical dendrite development

October 15, 2020

The research group of Takao Kohno (Nagoya City University) and Mitsuharu Hattori (Nagoya City University), Takahiko Kawasaki (National Institute of Genetics), and Kazunori Nakajima (Keio University School of Medicine) found a new mechanism by which superficial neurons correctly develop their dendrites. The results of this research were published in The Journal of Neuroscience, a journal published by the Society for Neuroscience.

The mammalian neocortex has an orderly and beautiful six-layer structure. Neurons in each layer develop the dendrites and form a normal network. Recently, it has been reported that dendritic abnormalities are found in patients with psychiatric disorders such as schizophrenia and autism. Therefore, understanding the mechanism by which dendrites are normally formed is important for the understanding those disorders. A large secretory glycoprotein called "Reelin" is essential for brain formation. Reelin plays various roles depending on the developmental stages, but its specific mechanism has not been understood. The research group has reported that the C-terminal region of Reelin, which is highly conserved among species, is required for dendrite development of superficial-layer neurons in the neocortex (Kohno et al., 2015). Here, Dr. Kohno and his colleagues identified neuropilin-1 (Nrp1) as a novel Reelin receptor. Previously, Reelin was found to undergo cleavage at 6 amino acids from the C-terminus (Kohno et al., 2015), but interestingly, the cleaved Reelin did not bind to Nrp1, indicating that the presence of 6 amino acid residues (0.17% of the total) regulates the binding between Nrp1 and Reelin.

In the mouse neocortex, Nrp1 and VLDLR were co-expressed in superficial-layer neurons and form a protein complex. Furthermore, Nrp1 enhanced the binding between Reelin and VLDLR, and the Reelin-Nrp1 interaction was necessary for the apical dendrite development in superficial neurons. These results suggested that a new mechanism mediated by the Reelin-Nrp1 interaction regulates the superficial-layer formation.

Recently, it has become clear that the dysfunction of Reelin is associated with the risk and onset of neuropsychiatric disorders. The research group has also reported that the tiny structural abnormalities in the brain are a risk of neuropsychiatric disorders-like behavior (Sakai et al., 2016). Our findings may lead to the understanding and therapeutic development of those disorders.
-end-


Nagoya City University

Related Neurons Articles from Brightsurf:

Paying attention to the neurons behind our alertness
The neurons of layer 6 - the deepest layer of the cortex - were examined by researchers from the Okinawa Institute of Science and Technology Graduate University to uncover how they react to sensory stimulation in different behavioral states.

Trying to listen to the signal from neurons
Toyohashi University of Technology has developed a coaxial cable-inspired needle-electrode.

A mechanical way to stimulate neurons
Magnetic nanodiscs can be activated by an external magnetic field, providing a research tool for studying neural responses.

Extraordinary regeneration of neurons in zebrafish
Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices.

Neurons thrive even when malnourished
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.

The first 3D map of the heart's neurons
An interdisciplinary research team establishes a new technological pipeline to build a 3D map of the neurons in the heart, revealing foundational insight into their role in heart attacks and other cardiac conditions.

Mapping the neurons of the rat heart in 3D
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

How to put neurons into cages
Football-shaped microscale cages have been created using special laser technologies.

A molecule that directs neurons
A research team coordinated by the University of Trento studied a mass of brain cells, the habenula, linked to disorders like autism, schizophrenia and depression.

Read More: Neurons News and Neurons Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.