Nav: Home

Learning during development is regulated by an unexpected brain region

October 16, 2017

During childhood, the brain goes through critical periods in which its learning ability for specific skills and functions is strongly increased. It is assumed that the beginning and ending of these critical periods are regulated in the cortex, the outermost layer of the brain. However, scientists from the Netherlands Institute for Neuroscience discovered that a structure deep in the brain also plays a crucial role in the regulation of these critical periods. These findings, published today in the leading journal Nature Neuroscience, have important implications for understanding developmental problems ranging from a lazy eye to intellectual disability.

Critical periods

We can only flawlessly learn skills and functions such as speaking a language or seeing in 3D through binocular vision during critical periods of development. When these developmental forms of learning fail, lifelong problems arise.

Scientists have been investigating the mechanisms by which critical periods are switched on and off in the hope to extend or reopen them for the treatment of developmental problems. Half a century of research on how the brain learns to integrate visual inputs from the two eyes has provided important insights in critical period regulation, leading to the conclusion that it occurs within the cortex. Neuroscientist Christiaan Levelt and his team now made the surprising discovery that a brain region that passes on input from the eyes to the cortex also plays a crucial role in opening the critical period of binocular vision.

Using electrophysiological recordings in genetically modified mice, they showed that this brain region, known as the thalamus, contains inhibitory neurons that regulate how efficiently the brain learns to integrate binocular inputs. Levelt: "To improve developmental problems resulting in learning problems during critical periods, reinstating flexibility in the visual cortex may not be sufficient. Scientists and clinicians should not limit themselves to studying cortical deficits alone. They should also focus on the thalamus and the way it preprocesses information before it enters the cortex."

Albinism

The study may also provide some hope for people with albinism, who often have limited binocular vision due to misrouting of inputs from the eyes to the thalamus. Levelt's team found that in contrast to what is generally assumed, plasticity of binocular vision also occurs in the thalamus itself, suggesting that this might be improved in children with albinism through training.
-end-


Netherlands Institute for Neuroscience - KNAW

Related Brain Articles:

Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.
Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.
Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.
Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.
BRAIN Initiative tool may transform how scientists study brain structure and function
Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions.
Wiring diagram of the brain provides a clearer picture of brain scan data
In a study published today in the journal BRAIN, neuroscientists led by Michael D.
Blue Brain Project releases first-ever digital 3D brain cell atlas
The Blue Brain Cell Atlas is like ''going from hand-drawn maps to Google Earth'' -- providing previously unavailable information on major cell types, numbers and positions in all 737 brain regions.
Landmark study reveals no benefit to costly and risky brain cooling after brain injury
A landmark study, led by Monash University researchers, has definitively found that the practice of cooling the body and brain in patients who have recently received a severe traumatic brain injury, has no impact on the patient's long-term outcome.
Brain cells called astrocytes have unexpected role in brain 'plasticity'
Researchers from the Salk Institute have shown that astrocytes -- long-overlooked supportive cells in the brain -- help to enable the brain's plasticity, a new role for astrocytes that was not previously known.
Largest brain study of 62,454 scans identifies drivers of brain aging
In the largest known brain imaging study, scientists from Amen Clinics (Costa Mesa, CA), Google, John's Hopkins University, University of California, Los Angeles and the University of California, San Francisco evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging.
More Brain News and Brain Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Teaching For Better Humans 2.0
More than test scores or good grades–what do kids need for the future? This hour, TED speakers explore how to help children grow into better humans, both during and after this time of crisis. Guests include educators Richard Culatta and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Space
One of the most consistent questions we get at the show is from parents who want to know which episodes are kid-friendly and which aren't. So today, we're releasing a separate feed, Radiolab for Kids. To kick it off, we're rerunning an all-time favorite episode: Space. In the 60's, space exploration was an American obsession. This hour, we chart the path from romance to increasing cynicism. We begin with Ann Druyan, widow of Carl Sagan, with a story about the Voyager expedition, true love, and a golden record that travels through space. And astrophysicist Neil de Grasse Tyson explains the Coepernican Principle, and just how insignificant we are. Support Radiolab today at Radiolab.org/donate.