Nav: Home

Novel reagent detects memory immune response in vaccinated animals

October 16, 2017

New Rochelle, NY, October 16, 2017--Researchers have developed a novel reagent capable of detecting rare, antigen-specific B cells that indicate successful vaccination in veterinary animals. The method used to create a B cell tetramer that can detect a memory immune response to porcine reproductive and respiratory syndrome virus (PRRSV) will be widely applicable for demonstrating immunity to other veterinary pathogens, and is presented in an article in Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Viral Immunology website.

The article entitled "B Cell Tetramer Development for Veterinary Vaccinology" is part of a special issue on Challenges in Veterinary Vaccines led by Guest Editor Crystal Loving, PhD, USDA-ARS National Animal Disease Center, Ames, IA.

Coauthors Michael Rahe, Kevin Gustafson, and Michael Murtaugh, University of Minnesota, St. Paul, described how the nsp7-B cell tetramer can be used to facilitate an in-depth understanding of the characteristics and quality of the memory B cell response generated to PRRSV infection and to vaccination against the virus. The researchers reported that validation studies showed the reagent able to detect PRRSV-specific B cells present at a frequency of about 0.001% of the total B lymphocytes in a vaccinated animal.

"The authors have done a wonderful job of extending B cell tetramer technology to the veterinary immunology field. This approach will be tremendously useful for the study of veterinary vaccines in general," says David L. Woodland, PhD, Editor-in Chief of Viral Immunology and Chief Scientific officer for Keystone Symposia on Molecular and Cellular Biology.

Research reported in this publication was supported by grants from National Institutes of Health under Award Number T32 OD010993. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
-end-
About the Journal

Viral Immunology is an authoritative peer-reviewed journal published ten times a year in print and online. Topics cover both human and animal viral immunology, exploring viral-based immunological diseases, pathogenic mechanisms, and virus-associated tumor and cancer immunology. The Journal includes original research papers, review articles, and commentaries covering the spectrum of laboratory and clinical research and exploring developments in vaccines and diagnostics targeting viral infections. Tables of content and a sample issue may be viewed on the Viral Immunology website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Journal of Interferon and Cytokine Research, AIDS Research and Human Retroviruses, and Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 http://www.liebertpub.com Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101

Mary Ann Liebert, Inc./Genetic Engineering News

Related Memory Articles:

How long does memory last? For shape memory alloys, the longer the better
Scientists captured live action details of the phase transitions of shape memory alloys, giving them a better idea how to improve their properties for applications.
Seeing it both ways: Visual perspective in memory
Think of a memory from your childhood. Are you seeing the memory through your own eyes, or can you see yourself, while viewing that child as if you were an observer?
A NEAT discovery about memory
UAB researchers say over expression of NEAT1, an noncoding RNA, appears to diminish the ability of older brains to form memories.
Molecular memory can be used to increase the memory capacity of hard disks
Researchers at the University of Jyväskylä have taken part in an international British-Finnish-Chinese collaboration where the first molecule capable of remembering the direction of a magnetic above liquid nitrogen temperatures has been prepared and characterized.
Memory transferred between snails
Memories can be transferred between organisms by extracting ribonucleic acid (RNA) from a trained animal and injecting it into an untrained animal, as demonstrated in a study of sea snails published in eNeuro.
An immunological memory in the brain
Inflammatory reactions can change the brain's immune cells in the long term -- meaning that these cells have an 'immunological memory.' This memory may influence the progression of neurological disorders that occur later in life, and is therefore a previously unknown factor that could influence the severity of these diseases.
Anxiety can help your memory
Anxiety can help people to remember things, a study from the University of Waterloo has found.
Pores with a memory
Whether for separation processes, photovoltaics, catalysis, or electronics, porous polymer membranes are needed in many fields.
Memory gene goes viral
Two independent teams of scientists from the University of Utah and the University of Massachusetts Medical School have discovered that a gene crucial for learning, called Arc, can send its genetic material from one neuron to another by employing a strategy commonly used by viruses.
Neurobiology: The chemistry of memory
Learning requires the chemical adaptation of individual synapses. Researchers have now revealed the impact of an RNA-binding protein that is intimately involved in this process on learning and memory formation and learning processes.
More Memory News and Memory Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Accessing Better Health
Essential health care is a right, not a privilege ... or is it? This hour, TED speakers explore how we can give everyone access to a healthier way of life, despite who you are or where you live. Guests include physician Raj Panjabi, former NYC health commissioner Mary Bassett, researcher Michael Hendryx, and neuroscientist Rachel Wurzman.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab