A new development in in vitro fertilisation (IVF) gives new hope to infertile couples

October 17, 2001

A case report published in BMC Pregnancy and Childbirth reports the success of a new IVF technique that resulted in a woman, who had been unable to conceive, giving birth to healthy twin boys.

Susan Adams and Christopher Murphy from the University of Sydney have devised a simple way of assessing the likelihood of an embryo implanting in the uterus using electron microscopy. They took a biopsy of uterine lining from a woman who had failed to conceive after several attempts at IVF, and examined it for structures called uterodomes, which are known to be associated with a receptive uterus. They found that uterodomes were almost completely absent.

The patient was then given the hormones oestrogen and progesterone until her uterine lining contained an abundance of uterodomes, judged by examining further tissue samples under the electron microscope. Encouraged by the changes they observed, Adams and Murphy decided to retry IVF. Implantation of frozen embryos succeeded on the first attempt, and the women subsequently gave birth to twins.

The researchers believe that the use of electron microscopy to assess the receptivity of the uterus to implantation could be a valuable tool, when used on a case-by-case basis, to help women who were previously unsuccessful in their attempts to become pregnant.
To read this article in full visit: http://www.biomedcentral.com/content/pdf/1471-2393-1-3.pdf*

*Note that BioMed Central articles are published in a preliminary format upon acceptance as supplied by the author. Articles are subsequently produced in a standard journal style.

BioMed Central

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