American Thoracic Society Journal news tips for October 2003 (second issue)

October 17, 2003

GUIDELINES PREDICT DIAGNOSIS OF DIFFICULT-TO-ASSESS HYPERSENSITIVITY PNEUMONITIS
A simple, noninvasive clinical predictive rule has been developed to guide clinical diagnosis for the difficult-to-assess disease called hypersensitivity pneumonitis. Canadian researchers presented data on 400 patients from seven clinical sites in different countries to develop a predictive rule that distinguishes those with the disease. Among the group, there were 116 patients with hypersensitivity pneumonitis (HP) and 284 without the disease. Of the 116 patients with HP, 71 had pigeon breeder's/bird fancier's disease and 25 had farmer's lung. The rule was tested on 261 additional patients to verify its accuracy. HP involves inflammation in the tiny air sacs of the lungs (alveoli) that is caused by an allergic reaction to inhaled organic dusts and occasionally, chemicals. After exposure, the lungs become inflamed and white blood cells accumulate in the walls of the alveoli. If a person has developed hypersensitivity to a specific organic dust, a fever, cough, chill, and shortness of breath typically appear 4 to 8 hours after exposure. The researchers point out that diagnosis of the disease is difficult and often relies on invasive tissue pathology. After identifying appropriate individual components of the history, physical examination, and basic laboratory results, the investigators said that the rule they developed could reduce the number of unnecessary invasive procedures, including surgical biopsy, in patients with typical characteristics of the disease. The study appears in the second issue for October 2003 of the American Thoracic Society's peer-reviewed American Journal of Respiratory and Critical Care Medicine.

MANAGEMENT OF PULMONARY INFECTIONS IN CYSTIC FIBROSIS
Inhaled antibiotics are being used by over 60 percent of U.S. patients with cystic fibrosis (CF) who have tested positive to the most significant pathogen affecting those with CF. The advantages of the technique involve direct delivery of high-dose antibiotics to an individual's bronchial space and limited systemic absorption and toxicity. These details are part of a comprehensive "State of the Art" article on the "Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis." The report is published in the second issue for October 2003 of the American Thoracic Society's peer-reviewed American Journal of Respiratory and Critical Care Medicine. CF is a hereditary disease that causes certain glands to produce abnormal secretions. The trait for the disease is recessive and requires two genes to produce illness. When two genes are abnormal, chloride and sodium transport across cell membranes is disrupted, leading to dehydration and increased stickiness of secretions. As part of the disease process, the mucus-producing glands in the lungs produce abnormal secretions that clog the airways and allow bacteria to grow. Across the U.S. population with CF, the average decline in lung function test scores is 2 percent per year. CF is the most common life-shortening genetic disorder in the white population. In the U.S. in 2001, the estimated median age to death for CF victims was 34.4 years, up six years from 1996. The authors point out that appropriate antibiotic therapy directed against bacterial pathogens isolated from the respiratory tract is an essential component of the management of CF lung disease. The articles notes that some initial studies with gene therapy have been encouraging, but significant barriers remain before efficient delivery and long-term expression of the transgene in the airway is achieved.
-end-
For the complete text of these articles, please see the American Thoracic Society Online Web Site at http://www.atsjournals.org. For either contact information or to request a complimentary journalist subscription to ATS journals online, or if you would like to add your name to the Society's twice monthly journal news e-mail list, contact Cathy Carlomagno at 212-315-6442, or by e-mail at ccarlomagno@thoracic.org

American Thoracic Society

Related Cystic Fibrosis Articles from Brightsurf:

Treating cystic fibrosis with mRNA therapy or CRISPR
The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation.

Cystic fibrosis: why so many respiratory complications?
Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders.

A newly discovered disease may lead to better treatment of cystic fibrosis
Cystic fibrosis is the most frequent severe inherited disorder worldwide.

New treatment kills off infection that can be deadly to cystic fibrosis patients
The findings, which are published in the journal Scientific Reports, show that scientists from Aston University, Mycobacterial Research Group, combined doses of three antibiotics -- amoxicillin and imipenem-relebactam and found it was 100% effective in killing off the infection which is usually extremely difficult to treat in patients with cystic fibrosis.

Cystic fibrosis carriers are at increased risk for cystic fibrosis-related conditions
A University of Iowa study challenges the conventional wisdom that having just one mutated copy of the cystic fibrosis (CF) gene has no effects on a person's health.

Rare mutations drive cystic fibrosis in Caribbean
Cystic Fibrosis (CF) in the Caribbean is dominated by unusual gene mutations not often observed in previously studied CF populations, according to comprehensive genome sequencing led by physician-scientists at UC San Francisco and Centro de Neumología Pediátrica in San Juan.

Cystic fibrosis carriers at increased risk of digestive symptoms
Researchers have found that carriers of the most common genetic variant that causes cystic fibrosis experience some symptoms similar to those of people with cystic fibrosis.

In cystic fibrosis, lungs feed deadly bacteria
A steady supply of its favorite food helps a deadly bacterium thrive in the lungs of people with cystic fibrosis, according to a new study by Columbia researchers.

Cibio knocks out cystic fibrosis
The fight against cystic fibrosis continues, targeting in particular some of the mutations that cause it.

Hypertonic saline may help babies with cystic fibrosis breathe better
Babies with cystic fibrosis may breathe better by inhaling hypertonic saline, according to a randomized controlled trial conducted in Germany and published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Read More: Cystic Fibrosis News and Cystic Fibrosis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.