Less invasive surgery effective in treatment of reflux disease

October 17, 2005

CHICAGO - Laparoscopic (minimally invasive) surgery to treat severe reflux disease was effective in relieving symptoms and was associated with high rates of patient satisfaction five years after the procedure, according to a study in the October issue of Archives of Surgery, one of the JAMA/Archives journals.

Laparoscopic anti-reflux surgery has been gaining in popularity for the treatment of severe symptomatic gastroesophageal reflux disease (GERD), according to background information in the article. Few previous studies have reported five-year follow-up for a large group of patients who have undergone laparoscopic surgery to treat severe reflux disease.

Patrick Pessaux, M.D., of the University Hospital, Angers, France, and colleagues evaluated patients who had undergone one of three types of laparoscopic anti-reflux surgery in one of 31 hospital centers between January 1992 and December 1998. Outcome data covering five or more years was available for 1,340 patients, 815 men and 525 women (average age 49.3 years). The average follow-up was 7.1 years. Patients were evaluated post-operatively using a standardized questionnaire including questions on gastrointestinal symptoms and satisfaction with surgery.

"In this study, the intraoperative and postoperative complication rates were 2.1 percent and 2.6 percent, respectively, with a subsequent operation rate of 4.4 percent at five years," the researchers report. "Of interest, overall patient satisfaction following surgery was high, with 93.1 percent of patients satisfied with their long-term outcome and 94.1 percent willing to have the surgery again. Although nearly 10 percent of patients resumed taking antisecretory medication, in most no evidence of reflux recurrence could be found."

"In conclusion, the results of this study do not differ significantly from the data reported in the literature, suggesting that laparoscopic antireflux surgery is an effective long-term procedure, is well tolerated, and can be properly used in the treatment of GERD," the authors write.
-end-
(Arch Surg. 2005; 140:946-951. Available pre-embargo to the media at www.jamamedia.org.)

For more information, contact JAMA/Archives Media Relations at 312-464-JAMA (5262) or email mediarelations@jama-archives.org.

The JAMA Network Journals

Related Disease Articles from Brightsurf:

CLCN6 identified as disease gene for a severe form of lysosomal neurodegenerative disease
A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder.

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

Potential link for Alzheimer's disease and common brain disease that mimics its symptoms
A new study by investigators from Brigham and Women's Hospital uncovered a group of closely related genes that may capture molecular links between Alzheimer's disease and Limbic-predominant Age-related TDP-43 Encephalopathy, or LATE, a recently recognized common brain disorder that can mimic Alzheimer's symptoms.

Antioxidant agent may prevent chronic kidney disease and Parkinson's disease
Researchers from Osaka University developed a novel dietary silicon-based antioxidant agent with renoprotective and neuroprotective effects.

Tools used to study human disease reveal coral disease risk factors
In a study published in Scientific Reports, a team of international researchers led by University of Hawai'i (UH) at Mānoa postdoctoral fellow Jamie Caldwell used a statistical technique typically employed in human epidemiology to determine the ecological risk factors affecting the prevalence of two coral diseases--growth anomalies, abnormalities like coral tumors, and white syndromes, infectious diseases similar to flesh eating bacteria.

Disease-aggravating mutation found in a mouse model of neonatal mitochondrial disease
The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome.

Human longevity largest study of its kind shows early detection of disease & disease risks
Human Longevity, Inc. (HLI) announced the publication of a ground-breaking study in the journal Proceedings of the National Academy of Sciences (PNAS).

30-year study identifies need of disease-modifying therapies for maple syrup urine disease
A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup Urine Disease (MSUD), which is among the most volatile and dangerous inherited metabolic disorders.

Long-dormant disease becomes most dominant foliar disease in New York onion crops
Until recently, Stemphylium leaf blight has been considered a minor foliar disease as it has not done much damage in New York since the early 1990s.

Read More: Disease News and Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.