Contralateral prophylactic mastectomy is a popular treatment among breast cancer patients

October 18, 2016

WASHINGTON, DC: Contralateral prophylactic mastectomy (CPM), a procedure in which women with early-stage breast cancer in one breast opt to undergo a more aggressive operation to remove both breasts, is performed at more than double the rate now than it was 10 years ago. However, the reasons why this may be happening are not always well understood. To learn why many patients were choosing to undergo this invasive procedure, and to see what kind of information patients were sharing with each other about it, a research team from the University of California, San Diego, looked at postings in an online health community.

The team learned that fear of recurrence was the most frequently identified reason for choosing CPM, according to study results presented at the 2016 Clinical Congress of the American College of Surgeons.

Lead study author Rebecca Marmor, MD, a general surgery resident in the Department of Surgery at the University of California, San Diego, and a clinical informatics fellow in the Division of Biomedical Informatics, said the rising rate of CPM is interesting when you consider the historical context of breast cancer surgery. Until about the 1980s, mastectomy was considered the standard of care. However, Dr. Marmor said, "as large trials came out demonstrating the efficacy of breast conservation, I think a lot of surgeons assumed that breast conservation would be patient's preference. We want to understand what is motivating some women who are choosing CPM, and sometimes even demanding it in the face of resistance from their own surgeons and oncologists."

The increased use of CPM is noted among all stages of breast cancer, even in patients with ductal carcinoma in-situ (stage 0). Recent data suggests that up to 25 percent of newly-diagnosed breast cancer patients are undergoing CPM, representing up to half of women undergoing mastectomy. Only about 5 percent of women with breast cancer received CPM in 2006, representing about 10-15 percent of mastectomies performed in that particular year.*

To conduct the study, the team did a keyword search in one online breast cancer community using the terms "contralateral," "prophylactic," and "double mastectomy" to identify relevant posts. Of the 20,189 posts, their search results returned 1,120 posts. Of those results, 541 were relevant from 286 posters. The researchers in turn found that 226 of those posters were the patients themselves, and 197 of them had previously made the decision to undergo CPM, while 29 were undecided. Among posters who identified reasons for choosing CPM, fear of recurrence was the most frequently identified reason.

After fear of recurrence, Dr. Marmor said, another reason was the perception that CPM is the best treatment for breast cancer. Some patients had already experienced a recurrence of breast cancer, so they opted for CPM because they wanted to stop the cancer from returning for good, Dr. Marmor said. Others said plastic surgeons recommended CPM to them to optimize their cosmetic reconstruction outcomes.

Dr. Marmor said previous studies have looked at the increase in CPM, but her team's study was unique because they were able to see the actual communication between patients themselves.

"Now we have a better understanding of what beliefs some patients hold, which is that CPM is the best treatment for breast cancer. We also were able to study what patients are saying to each other about CPM. Now that we have a sense of what they're saying to each other, we want to work to correct their misconceptions," Dr. Marmor said. She said the team is currently performing the analysis on another health community to make sure the results are consistent. Then, she said, they're hoping to develop a tool to aggregate patient experiences so women can learn about different treatment options from other patients similar to themselves.

Dr. Marmor's co-investigators for the study include Anna R. Schoenbrunner; Sarah L. Blair, MD, FACS; and Jina Huh, PhD, University of California, San Diego.

"FACS" designates that a surgeon is Fellow of the American College of Surgeons.
*Angelos, P., Bedrosian, I., Euhus, D.M. et al. "Contralateral Prophylactic Mastectomy: Challenging Considerations for the Surgeon," Ann Surg Oncol (2015) 22: 3208, accessed September 1, 2016, doi:10.1245/s10434-015-4758-y.

About the American College of Surgeons

The American College of Surgeons is a scientific and educational organization of surgeons that was founded in 1913 to raise the standards of surgical practice and improve the quality of care for surgical patients. The College is dedicated to the ethical and competent practice of surgery. Its achievements have significantly influenced the course of scientific surgery in America and have established it as an important advocate for all surgical patients. The College has more than 80,000 members and is the largest organization of surgeons in the world. For more information, visit (.)

American College of Surgeons

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