Nav: Home

CHLA awarded grant to study immunotherapy resistance in neuroblastoma

October 18, 2016

A team of investigators at Children's Hospital Los Angeles has received a major, three-year grant from the V Foundation for Cancer Research to study the effects of chemoimmunotherapy in children with neuroblastoma.

Neuroblastoma is the most common solid tumor occurring outside the brain in children. Less than 50 percent of patients with high-risk disease survive. Recent pilot data showed unprecedented results from using chemoimmunotherapy - a combination of chemotherapy and immunotherapy - on the more than half of treatment-resistant patients.

"These early results are very exciting and have changed the standard of care for these children," said Shahab Asgharzadeh, MD, director of the Basic and Translational Neuroblastoma program at CHLA's Children's Center for Cancer and Blood Diseases. "We would like to thank the V Foundation for their support of research into the mechanism of action of chemoimmunotherapy in childhood neuroblastoma so that, hopefully, we can discover how to make it effective for all children with this devastating disease."

This grant will fund research to discover how chemoimmunotherapy acts to destroy neuroblastoma. This information will provide the investigators with insights as to why some patients fail to respond. Armed with this knowledge, the researchers can develop strategies for modifying chemoimmunotherapy so that it effectively fights neuroblastoma in children that currently fail to respond to this treatment.

Other investigators on the team include: Robert Seeger, MD, director of the Cancer Research program, CHLA; Araz Marachelian, MD, medical director of New Approach to Neuroblastoma (NANT) consortium, CHLA ; and John Carptem, director of the Institute for Translational Genomics, Keck School of Medicine of USC.
-end-
About Children's Hospital Los Angeles

Children's Hospital Los Angeles has been named the best children's hospital on the West Coast and among the top five in the nation for clinical excellence with its selection to the prestigious U.S. News & World Report Honor Roll. Children's Hospital is home to The Saban Research Institute, one of the largest and most productive pediatric research facilities in the United States. Children's Hospital is also one of America's premier teaching hospitals through its affiliation since 1932 with the Keck School of Medicine of the University of Southern California.

For more information, visit CHLA.org. Follow us on our blog http://researchlablog.org/.

Children's Hospital Los Angeles

Related Cancer Articles:

Radiotherapy for invasive breast cancer increases the risk of second primary lung cancer
East Asian female breast cancer patients receiving radiotherapy have a higher risk of developing second primary lung cancer.
Cancer genomics continued: Triple negative breast cancer and cancer immunotherapy
Continuing PLOS Medicine's special issue on cancer genomics, Christos Hatzis of Yale University, New Haven, Conn., USA and colleagues describe a new subtype of triple negative breast cancer that may be more amenable to treatment than other cases of this difficult-to-treat disease.
Metabolite that promotes cancer cell transformation and colorectal cancer spread identified
Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread.
UH Cancer Center researcher finds new driver of an aggressive form of brain cancer
University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age.
UH Cancer Center researchers develop algorithm to find precise cancer treatments
University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze 'Big Data' obtained from tumor samples to better understand and treat cancer.
New analytical technology to quantify anti-cancer drugs inside cancer cells
University of Oklahoma researchers will apply a new analytical technology that could ultimately provide a powerful tool for improved treatment of cancer patients in Oklahoma and beyond.
Radiotherapy for lung cancer patients is linked to increased risk of non-cancer deaths
Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.
Cancer expert says public health and prevention measures are key to defeating cancer
Is investment in research to develop new treatments the best approach to controlling cancer?
UI Cancer Center, Governors State to address cancer disparities in south suburbs
The University of Illinois Cancer Center and Governors State University have received a joint four-year, $1.5 million grant from the National Cancer Institute to help both institutions conduct community-based research to reduce cancer-related health disparities in Chicago's south suburbs.
Leading cancer research organizations to host international cancer immunotherapy conference
The Cancer Research Institute, the Association for Cancer Immunotherapy, the European Academy of Tumor Immunology, and the American Association for Cancer Research will join forces to sponsor the first International Cancer Immunotherapy Conference at the Sheraton New York Times Square Hotel in New York, Sept.

Related Cancer Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".