Cytokine mediates obesity-related factors linked to colorectal cancer

October 18, 2018

New Rochelle, NY, October 18, 2018--A new study describes the mechanistic relationship between the cytokine interleukin-1ß, (IL-1ß) and obesity, showing that when IL-1ß levels are increased in obesity, IL-1 receptor signaling activates multiple pathways leading to colon cancer. The study shows that obesity is linked with systemic increases in IL-1ß, activation of Wnt, and proliferation of mouse colon cells, as reported in an article published in Journal of Interferon & Cytokine Research (JICR) from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Journal of Interferon & Cytokine Research (JICR) website through November 18, 2018.

Joel Mason, Tufts University and Tufts University School of Medicine, Boston MA, and colleagues from Tufts University, coauthored the article entitled "Interleukin-1 Signaling Mediates Obesity-Promoted Elevations in Inflammatory Cytokines, Wnt Activation, and Epithelial Proliferation in the Mouse Colon."

The researchers set out to define the role of IL-1ß in mediating the events leading up to obesity-promoted colorectal cancer. They compared the role of IL-1ß in mice fed either a high-fat (obese) or low-fat (lean) diet. Among the changes they found were that obese mice had 30-80% greater concentrations of IL-1ß in the colonic mucosa, a significant increase in the Wnt signaling cascade, and a significant expansion in the proliferation zone of the colonic crypt.

"This study reveals the close linkage of obesity and the inflammatory response and reflects the broad actions of IL-1ß that define obesity as one of many inflammatory diseases," says Journal of Interferon & Cytokine Research Editor-in-Chief Michael Gale Jr., Department of Immunology, University of Washington, Center for Innate Immunity and Immune Disease.
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About the Journal

Journal of Interferon & Cytokine Research (JICR), led by Editor-in-Chief Michael Gale Jr., Department of Immunology, University of Washington, Center for Innate Immunity and Immune Disease, is an authoritative peer-reviewed journal published monthly online with open access options and in print that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is an official journal of the International Cytokine & Interferon Society. (http://cytokinesociety.org/) Complete tables of content and a sample issue may be viewed on the JICR website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

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