E-cigarettes may trigger unique and potentially damaging immune responses

October 20, 2017

Oct. 18, 2017--E-cigarettes appear to trigger unique immune responses as well as the same ones that cigarettes trigger that can lead to lung disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In "E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion," Mehmet Kesimer, PhD, senior study author and associate professor of pathology at the University of North Carolina Chapel Hill, and coauthors report findings from what they believe is the first study to use human airway samples to explore the harmful effects of e-cigarettes.

"There is confusion about whether e-cigarettes are 'safer' than cigarettes because the potential adverse effects of e-cigarettes are only beginning to be studied," Dr. Kesimer said, noting that this study looked at possible biomarkers of harm in the lungs. "Our results suggest that e-cigarettes might be just as bad as cigarettes."

A 2016 Surgeon General's report found that e-cigarette use increased by 900 percent among high school students from 2011 to 2015. Also in 2016, the Food and Drug Administration extended its regulatory oversight of tobacco products to include e-cigarettes.

The study compared sputum samples from 15 e-cigarette users, 14 current cigarette smokers and 15 non-smokers. They found e-cigarette users uniquely exhibited significant increases in: The study also found that e-cigarettes produced some of the same negative consequences as cigarettes. Both e-cigarette and cigarette users exhibited significant increases in: Study limitations include the fact that of the 15 e-cigarette users, 5 said they occasionally smoked cigarettes and 12 identified themselves as having smoked cigarettes in the past.

"Comparing the harm of e-cigarettes with cigarettes is a little like comparing apples to oranges," Dr. Kesimer said. "Our data shows that e-cigarettes have a signature of harm in the lung that is both similar and unique, which challenges the concept that switching from cigarettes to e-cigarettes is a healthier alternative."
-end-
About the American Journal of Respiratory and Critical Care Medicine (AJRCCM):

The AJRCCM is a peer-reviewed journal published by the American Thoracic Society. The Journal takes pride in publishing the most innovative science and the highest quality reviews, practice guidelines and statements in pulmonary, critical care and sleep medicine. With an impact factor of 12.996, it is the highest ranked journal in pulmonology. Editor: Jadwiga Wedzicha, MD, professor of respiratory medicine at the National Heart and Lung Institute (Royal Brompton Campus), Imperial College London, UK.

About the American Thoracic Society:

Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy. The ATS publishes three journals, the American Journal of Respiratory and Critical Care Medicine, the American Journal of Respiratory Cell and Molecular Biology and the Annals of the American Thoracic Society.

The ATS will hold its 2018 International Conference, May 18-23, in San Diego, California, where world-renowned experts will share the latest scientific research and clinical advances in pulmonary, critical care and sleep medicine.

American Thoracic Society

Related Biomarkers Articles from Brightsurf:

Urgent need for blood-based biomarkers to diagnosis concussion
There is an urgent need for objective markers for diagnosing concussion, or mild traumatic brain injury.

Engineered bacteria churn out cancer biomarkers
A Cornell lab has created these very tools by commandeering simple, single-celled microorganisms - namely E. coli bacteria - and engineering them to explore the complex process of glycosylation and the functional role that protein-linked glycans play in health and disease.

Exercise induces secretion of biomarkers into sweat
The aim was to reveal the potential of microRNAs in sweat extracellular vesicles in monitoring exercise performance.

Phosphoprotein biomarkers to guide cancer therapy are identified
Researchers led by James Bibb, Ph.D., professor of surgery at the University of Alabama at Birmingham, suggest using a broader lens of post-translational modification analysis to identify new biomarkers of cancer drivers that may allow a much more precise prediction of patient responses to treatments.

Exhaled biomarkers can reveal lung disease
Using specialized nanoparticles, MIT engineers have developed a way to diagnose pneumonia or other lung diseases by analyzing the breath exhaled by the patient.

Race-specific lupus nephritis biomarkers
A University of Houston biomedical researcher has discovered a difference in urinary biomarker proteins of lupus nephritis in patients according to race.

Semen miRNAs could be non-invasive biomarkers for prostate cancer
Researchers of the Human Molecular Genetics group at the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr.

Scientists have found longevity biomarkers
An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity.

After concussion, biomarkers in the blood may help predict recovery time
A study of high school and college football players suggests that biomarkers in the blood may have potential use in identifying which players are more likely to need a longer recovery time after concussion, according to a study published in the July 3, 2019, online issue of Neurology, the medical journal of the American Academy of Neurology.

3D-printed device detects biomarkers of preterm birth
Preterm birth (PTB) -- defined as birth before the 37th week of gestation -- is the leading complication of pregnancy.

Read More: Biomarkers News and Biomarkers Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.