Biopharmaceutical manufacturing efficiencies signal reduced healthcare costs

October 21, 2004

October 13, 2004 (Washington, DC) - Cost reductions associated with advances in large-scale biopharmaceutical manufacturing will play a role in reducing healthcare costs, according to a new industry joint publication by ASM Press, the book publishing division of the American Society for Microbiology, and BioPlan Associates. Advances in Large-Scale Biopharmaceutical Manufacturing and Scale-up Production details the importance of cost reductions in biopharmaceutical manufacturing--paramount to the segment's competitiveness and the effort to reduce healthcare costs. US healthcare spending now accounts for 15% of GDP. And according to ex-FDA Commissioner Mark McClelland, manufacturing can constitute half of a pharmaceutical company's expenses, so it is a prime target for cost reduction measures.

"Scale-up and improvements in efficiency are the obvious keys to reduction in costs and to the wider availability of life-saving products, but the investments required may also compete with resources available for discovery research and new product development," says Acambis Chief Scientific Officer Tom Monath. "However, it is clear that bioengineering advances and scale-up are the keys to the reduction of manufacturing costs."

The study identifies the challenges involved in the search for process improvements while recognizing that change may be constrained by practical and regulatory concerns. The study addresses new frontiers in bioprocessing and novel technologies, technical issues in protein expression and other areas, and offers an analysis of scale-up production factors, product purification, process design, good automation manufacturing practices, and regulatory compliance issues. It also discusses commercial market dynamics, worldwide capacity factors, demand forecasting, strategic decision-making, intellectual property, capital investment, and biopharmaceutical manufacturing training. Contributing author organizations include Amgen, BD Technologies, Burrill & Co., Eli Lilly, Ernst & Young, GE Healthcare, Merck Research Laboratories, National Institutes of Health, and many others.
-end-
The American Society for Microbiology is the oldest and largest single life science membership organization in the world. The ASM's mission is to promote research in the microbiological sciences and to assist communication between scientists, policy makers, and the public to improve health and foster economic well-being. Advances in Large-Scale Biopharmaceutical Manufacturing and Scale-up Production was edited by Eric Langer of BioPlan Associates, Inc. which has provided market assessment services to biopharmaceutical and healthcare companies since1989 (www.bioplanassociates.com).

American Society for Microbiology

Related Manufacturing Articles from Brightsurf:

Analyzing pros and cons of two composite manufacturing methods
Airplane wings and wind turbine blades are typically created using bulk polymerization in composite manufacturing facilities.

Cellulose for manufacturing advanced materials
The last decade has seen an increase in scientific publications and patents on cellulose, the most abundant natural polymer.

Study analyzes contamination in drug manufacturing plants
A study from an MIT-led consortium, which analyzed 18 incidents of viral contamination at biopharmaceutical manufacturing plants, offers insight into the most common sources of viral contamination, and makes recommendations to help companies avoid such incidents.

The integrated catalysts can simplify pharmaceutical manufacturing
Prof. In Su Lee and his research team from POSTECH developed catalytic platforms based on metal organic frameworks.

Highest throughput 3D printer is the future of manufacturing
Northwestern University researchers have developed a new, futuristic 3D printer that is so big and so fast it can print an object the size of an adult human in just a couple of hours.

A new manufacturing process for aluminum alloys
Using a novel Solid Phase Processing approach, a research team at Pacific Northwest National Laboratory eliminated several steps that are required during conventional extrusion processing of aluminum alloy powders, while also achieving a significant increase in product ductility.

Researchers develop new lens manufacturing technique
Researchers from Washington State University and Ohio State University have developed a low-cost, easy way to make custom lenses that could help manufacturers avoid the expensive molds required for optical manufacturing.

Nanocrystal 'factory' could revolutionize quantum dot manufacturing
A new system for synthesizing quantum dots across the entire spectrum of visible light drastically reduces manufacturing costs, can be tuned on demand to any color and allows for real-time process monitoring to ensure quality control.

NIST: Blockchain provides security, traceability for smart manufacturing
Engineers at the National Institute of Standards and Technology (NIST) needed a way to secure smart manufacturing systems using the digital thread , so they turned to the new kid on the block ... blockchain, that is.

Microbial manufacturing
Led by Emily Balskus, Professor of Chemistry and Chemical Biology, a team of researchers has untangled how bacteria found in soil are able to manufacture streptozotocin, showing for the first time that the compound is produced through an enzymatic pathway and revealing the novel chemistry that drives the process.

Read More: Manufacturing News and Manufacturing Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.