Research on premature birth boosted with $10 Million NIH grant

October 21, 2005

Researchers at Yale School of Medicine have received over $10 million from the National Institutes of Health (NIH) for four and a half years to fund research initiatives in preterm births.

The grant from the National Institutes on Child Health and Human Development (NICHD) will form a data management, statistics and informatics core at Yale and support a National Genomic and Proteomic Network for Preterm Birth Research. This five-site network will identify genetic and environmental determinants of premature birth and provide a public resource for future research on preterm birth. Other institutions conducting the research with Yale are the University of Pennsylvania, the University of Utah, the University of Texas Medical Branch and the University of Alabama at Birmingham.

Heping Zhang, professor of biostatistics in the Department of Epidemiology and Public Health (EPH) and professor in the Child Study Center is principal investigator of the core grant to Yale School of Medicine. He will oversee study design, data management, statistics, informatics, coordination and administration of funding for the entire network.

"This multidisciplinary and multi-center network will be able to recruit a large and representative population of preterm births and utilize advanced genomic technologies and statistical methods," said Zhang. "This combination of a large sample with the advanced technologies is critically important to the understanding of complex diseases and conditions such as preterm births."

Yale School of Medicine Dean Robert J. Alpern, M.D., said, "I am delighted that the NIH has chosen one of Yale's faculty members to lead this program. Dr. Zhang is an outstanding biostatistician with much experience in leading clinical trials such as this one."

Director of the NICHD, Duane Alexander, M.D., said the network is one of the major efforts and top priorities of the Institute. The goal of the network is to obtain an understanding of the pathophysiology of preterm birth, discover target molecules and diagnostic biomarkers and aid in innovating and implementing strategies for premature birth intervention.

Premature birth is a leading cause of infant mortality. Although advances have been made in the identification of some possible causes of prematurity, such as intrauterine infection, uterine bleeding, excessive uterine stretch, maternal psychosocial stress and fetal physiological stress, more understanding is needed to implement effective interventions.

Prakash Nadkarni, M.D., associate professor of anesthesiology and EPH, and Kei Cheung, assistant professor at Yale Center for Medical Informatics and Genetics, will direct the data management and informatics. Laura Ment, M.D., professor of pediatrics at Yale, and Kenneth Williams, director of Yale's W.M. Keck Foundation Biotechnology Resource Laboratory, will provide clinical and scientific expertise. Analisa Lozano, coordinator in EPH, will serve as network coordinator.

Yale University

Related Public Health Articles from Brightsurf:

COVID-19 and the decolonization of Indigenous public health
Indigenous self-determination, leadership and knowledge have helped protect Indigenous communities in Canada during the coronavirus disease 2019 (COVID-19) pandemic, and these principles should be incorporated into public health in future, argue the authors of a commentary in CMAJ (Canadian Medical Association Journal)

Public health consequences of policing homelessness
In a new study examining homelessness, researchers find that policy such a lifestyle has massive public health implications, making sleeping on the street even MORE unhealthy.

Electronic health information exchange improves public health disease reporting
Disease tracking is an important area of focus for health departments in the midst of the COVID-19 pandemic.

Pandemic likely to cause long-term health problems, Yale School of Public Health finds
The coronavirus pandemic's life-altering effects are likely to result in lasting physical and mental health consequences for many people--particularly those from vulnerable populations--a new study led by the Yale School of Public Health finds.

The Lancet Public Health: US modelling study estimates impact of school closures for COVID-19 on US health-care workforce and associated mortality
US policymakers considering physical distancing measures to slow the spread of COVID-19 face a difficult trade-off between closing schools to reduce transmission and new cases, and potential health-care worker absenteeism due to additional childcare needs that could ultimately increase mortality from COVID-19, according to new modelling research published in The Lancet Public Health journal.

The Lancet Public Health: Access to identification documents reflecting gender identity may improve trans mental health
Results from a survey of over 20,000 American trans adults suggest that having access to identification documents which reflect their identified gender helps to improve their mental health and may reduce suicidal thoughts, according to a study published in The Lancet Public Health journal.

The Lancet Public Health: Study estimates mental health impact of welfare reform, Universal Credit, in Great Britain
The 2013 Universal Credit welfare reform appears to have led to an increase in the prevalence of psychological distress among unemployed recipients, according to a nationally representative study following more than 52,000 working-age individuals from England, Wales, and Scotland over nine years between 2009-2018, published as part of an issue of The Lancet Public Health journal on income and health.

BU researchers: Pornography is not a 'public health crisis'
Researchers from the Boston University School of Public Health (BUSPH) have written an editorial in the American Journal of Public Health special February issue arguing against the claim that pornography is a public health crisis, and explaining why such a claim actually endangers the health of the public.

The Lancet Public Health: Ageism linked to poorer health in older people in England
Ageism may be linked with poorer health in older people in England, according to an observational study of over 7,500 people aged over 50 published in The Lancet Public Health journal.

Study: Public transportation use linked to better public health
Promoting robust public transportation systems may come with a bonus for public health -- lower obesity rates.

Read More: Public Health News and Public Health Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to