West African bats -- no safe haven for malaria parasites

October 21, 2013

In Europe, bats are normally discussed in the context of endangered species threatened by loss of their habitats. However, in recent years, bats have caught the eye of infection biologists. The animals are namely hosts to a surprising number of pathogens, many of which could be dangerous to humans. Scientists at the Max Planck Institute for Infection Biology, the Museum für Naturkunde in Berlin and the American Museum of Natural History have been able to identify in West African bats four genera of parasites that are closely related to the malaria pathogen. One of them is the genus Plasmodium, which also includes the species that cause malaria in humans. The Plasmodium species in bats are very similar to that found in rodents and could advance the study of malaria pathogens' defence strategies against immune system responses.

Bats can transmit various diseases to human beings. Indeed, they serve as reservoir hosts for a long list of pathogens, including the "who's who" of dreaded killer viruses: Ebola, Marburg, Nipah, Hendra and Lyssa. The SARS outbreak in 2002 in Asia and the transmission of a previously unidentified virus (MERS) to humans in the Middle East in 2013 can both be traced back to viruses that have switched hosts from bats to humans. Bats have an exceptional immune system that can hold all these viruses in check. However, some infections in humans often have a deadly outcome.

Recently, the researchers have also found an astonishing variety of blood parasites in West African bats. They examined 31 bat species from the West African forest in Guinea, Liberia and the Ivory Coast with regard to parasites that attack red blood cells. 40 per cent of the approximately 270 examined animals carried parasites of the genera Plasmodium, Polychromophilus, Nycteria and Hepatocystis. According to the study, at least two species of Plasmodium can be found in bats. These bat pathogens are very similar to those found in rodents. "There are different arboreal rodents in the tropics that live in close vicinity to bats and in result might attract the same mosquitoes that transmit parasites from one group of animals to another," says Juliane Schaer from the Max Planck Institute in Berlin.

Plasmodium parasites cause malaria, the most important vector-borne infectious disease on the planet. These protozoan parasites reproduce in different host cells and undergo a complex life cycle in two alternating hosts. Their sexual reproduction takes place in insects; usually Anopheles mosquitoes. Following a mosquito bite, they reproduce asexually in different vertebrates. By comparing DNA, the scientists were able to establish a phlyogenetic tree for haemosporidians in bats. This showed that bats were the first mammal hosts to the pathogens. "In a later evolutionary stage, they switched to rodents and primates," Susan Perkins from the American Museum of Natural History in New York says.

It is not yet clear why bats are hosts to such a multitude of microorganisms. "One reason is probably that, in evolutionary terms, this is a very old group of animals, which moreover comprises a large number of different species. The bats' ability to fly and their tendency to form big colonies are other factors that help the parasites spread," explains Schaer.

As a consequence of the pathogen threat, bats have developed a sophisticated immune system. This might explain the finding that certain bat species show infection rates of over 60 per cent by haemosporidians and still manage to keep the parasites at bay without becoming ill. "Also, the fast asexual reproduction of the genera Polychromophilus, Nycteria and Hepatocystis in bats takes place in hepatocytes, and not in erythrocytes as in humans. Such a liver stage cannot be clinically detected in humans. "It may be that the effective immune system ousted the pathogens from the blood cells, so that they were limited to multiply in the liver," says Kai Matuschewski, Leader of the Parasitology Research Group at the Max Planck Institute for Infection Biology.

For the scientists, the bat haemosporidians offer an opportunity for studying how the pathogens adapt to new organisms and thus also the immune responses of an organism. In addition, they hope to learn more about malaria parasites in humans. Many studies focussing on vaccines and antimalarial drugs make use of mouse models. As the parasites found in bats are so similar to those in rodents, it may be easy to transfer them to mice and study them closer.
-end-
Original publication:

High diversity of West African bat malaria parasites and a tight link with rodent Plasmodium taxa Juliane Schaer, Susan L. Perkins, Jan Decher, Fabian H. Leendertz, Jakob Fahr, Natalie Weber, and Kai Matuschewski

Max-Planck-Gesellschaft

Related Malaria Articles from Brightsurf:

Clocking in with malaria parasites
Discovery of a malaria parasite's internal clock could lead to new treatment strategies.

Breakthrough in malaria research
An international scientific consortium led by the cell biologists Volker Heussler from the University of Bern and Oliver Billker from the UmeƄ University in Sweden has for the first time systematically investigated the genome of the malaria parasite Plasmodium throughout its life cycle in a large-scale experiment.

Scientists close in on malaria vaccine
Scientists have taken another big step forward towards developing a vaccine that's effective against the most severe forms of malaria.

New tool in fight against malaria
Modifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs.

Malaria expert warns of need for malaria drug to treat severe cases in US
The US each year sees more than 1,500 cases of malaria, and currently there is limited access to an intravenously administered (IV) drug needed for the more serious cases.

Monkey malaria breakthrough offers cure for relapsing malaria
A breakthrough in monkey malaria research by two University of Otago scientists could help scientists diagnose and treat a relapsing form of human malaria.

Getting to zero malaria cases in zanzibar
New research led by the Johns Hopkins Center for Communication Programs, Ifakara Health Institute and the Zanzibar Malaria Elimination Program suggests that a better understanding of human behavior at night -- when malaria mosquitoes are biting -- could be key to preventing lingering cases.

Widely used malaria treatment to prevent malaria in pregnant women
A global team of researchers, led by a research team at the Liverpool School of Tropical Medicine (LSTM), are calling for a review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.

Protection against Malaria: A matter of balance
A balanced production of pro and anti-inflammatory cytokines at two years of age protects against clinical malaria in early childhood, according to a study led by ISGlobal, an institution supported by ''la Caixa'' Foundation.

The math of malaria
A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting.

Read More: Malaria News and Malaria Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.