Tufts Medical Center to lead 20-center study on vitamin D's effect on Type 2 diabetes

October 21, 2013

October 21, 2013 (BOSTON) -A research team led by Anastassios G. Pittas, MD, MS, Endocrinologist and Co-Director of the Diabetes Center at Tufts Medical Center in Boston, has received a National Institutes of Health (NIH) grant of more than $40 million over five years to conduct the Vitamin D and Type 2 diabetes (D2d) study (http://www.d2dstudy.org). D2d is a nationwide clinical trial to determine if vitamin D supplementation can reduce the likelihood of developing type 2 diabetes in people who are at high risk for this serious metabolic disorder.

Despite a lack of conclusive evidence to the effectiveness of vitamin D for conditions not related to bone health, sales of vitamin D supplements in the United States have skyrocketed to $425 million annually, making it one of the top selling supplements in the country and one of the most talked about topics in health and medicine. The D2d study, which is coordinated out of the Division of Endocrinology at Tufts Medical Center, is the first of its kind to specifically examine whether vitamin D has an effect on prevention of type 2 diabetes.

"Early studies, by our team and others, suggest a strong link between vitamin D and reduction of diabetes risk," said Pittas, who has investigated the connection since 2002. "While there is a lot of hype about vitamin D and its health benefits, including for diabetes, there is not yet enough evidence from clinical trials to support a recommendation of vitamin D supplementation for diabetes prevention. If the D2d study confirms our hypothesis, it could have a significant impact on the quality of life for millions of people and could potentially save the American health care system billions of dollars."

According to the Centers for Disease Control and Prevention, diabetes is the 7th-leading cause of death in the United States, responsible for more than 69,000 fatalities in 2010. A chronic disease with no known cure, diabetes also can lead to other severe health complications, including stroke, blindness, and diseases of the heart, kidney and nervous system. Data from the 2011 National Diabetes Fact Sheet indicates that nearly 26 million Americans are currently living with the disease; 79 million more (about one-third of the adult U.S. population) are at a high risk for developing type 2 diabetes. The American Diabetes Association estimates that diabetes cost the U.S. health care system approximately $245 billion in 2012.

"Maintaining a healthy diet and staying physically active is the best way to lower the risk of type 2 diabetes," said Pittas. "However, achieving and maintaining the required lifestyle changes long-term is a challenge for many people. Therefore, it is critical to find new preventive measures that are safe, effective, affordable and easily applied to prevent future type 2 diabetes cases."

About 2,500 people at high risk for diabetes will be recruited for this landmark trial, which will take place at 20 medical centers in 17 different states across the country. Participants will receive either vitamin D supplementation or placebo, and will be followed for development of diabetes twice a year for approximately four years. Results of the D2d study are expected in 2018.

"At the completion of the study, our goal is to have conclusive evidence as to whether vitamin D supplementation lowers the risk of diabetes," said D2d Project Manager Patricia Sheehan, RN, MPH, MS. "The first step in reaching this objective is encouraging people at high risk for diabetes to take part in this important clinical trial."
-end-
D2d at Tufts Medical Center is now inviting people at risk for diabetes in the Boston metropolitan area to join the study. Those at risk for diabetes include people who are overweight, have a family member with type 2 diabetes, live a sedentary lifestyle, or have high blood pressure; members of certain ethnic groups, including African Americans, Hispanic Americans, Native Americans, and Asian Americans; and women who had diabetes during pregnancy. For more information or to enroll in the D2d study, please call 617-636-2843, e-mail d2dtufts@tuftsmedicalcenter.org or visit the study's website at http://www.D2dstudy.org.

D2d (ClinicalTrials.gov number NCT01942694) is supported under NIH grant U01DK098245. The National Institute of Diabetes and Digestive and Kidney Diseases, part of NIH, is the primary sponsor of the trial, with additional support from the NIH Office of Dietary Supplements and the American Diabetes Association. Support in the form of educational materials is provided by the National Diabetes Education Program.

About Tufts Medical Center and Floating Hospital for Children

Tufts Medical Center is an exceptional, not-for-profit, 415-bed academic medical center that is home to both a full-service hospital for adults and Floating Hospital for Children. Conveniently located in downtown Boston, the Medical Center is the principal teaching hospital for Tufts University School of Medicine. Floating Hospital for Children is the full-service children's hospital of Tufts Medical Center and the principal pediatric teaching hospital of Tufts University School of Medicine. For more information, please visit http://www.tuftsmedicalcenter.org.

Tufts Medical Center

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.