Nav: Home

Electrical stimulation of the esophagus promising treatment for unresolved reflux symptoms

October 22, 2012

Las Vegas, NV, (October 22, 2012) - Clinical evidence of the safety and effectiveness of electrical stimulation of a muscular valve in the esophagus demonstrates promising results in resolving symptoms of gastroesophageal reflux (GERD) and is being presented at the 77th Annual Scientific Meeting of the American College of Gastroenterology in Las Vegas, NV.

Three studies examined small numbers of patients who had a device implanted that uses low energy electrical pulses to strengthen a weak or dysfunctional lower esophageal sphincter (LES) which is the underlying cause of GERD or acid reflux. The LES is the ring shaped muscular valve that keeps the acidic contents of the stomach from the esophagus, or food tube.

Two studies by investigators Michael Crowell, Ph.D., FACG of Mayo Clinic Scottsdale and Edy Soffer, MD, FACG of the University of Southern California looked at various endpoints including esophageal acid exposure, improvement in GERD symptoms, and reduction of use of acid-suppressing medications known as proton pump inhibitors. In a study of 25 patients, the investigators found that 77 percent of patients reported either normalization or at least a 50 percent reduction in PPI use. At 12 months after the implant of the device, there was a statistically significant improvement in patients' scores on a scale measuring health-related quality of life for patients with GERD. The authors conclude, "Electrical stimulation of the lower esophageal sphincter is effective for treating patients with GERD over long-term year duration." The authors reported relationships with the Netherlands-based EndoStim BV which manufactures the device.

In a separate and unrelated study, Arjan Bredenoord, MD and colleagues at the University Medical Center Utrecht in Rotterdam, The Netherlands, presented a study at ACG of eleven patients with refractory GERD symptoms with devices implanted in the LES. They found that ten of the eleven patients (91 percent) were able to discontinue PPI medications. Overall, their research revealed a statistically significant improvement in patients' GERD symptoms, as well as a trend in improvement in their esophageal pH.
-end-
About the American College of Gastroenterology

Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of more than 12,000 individuals from 80 countries. The College is committed to serving the clinically oriented digestive disease specialist through its emphasis on scholarly practice, teaching and research. The mission of the College is to serve the evolving needs of physicians in the delivery of high quality, scientifically sound, humanistic, ethical, and cost-effective health care to gastroenterology patients. www.gi.org View releases on other research breaking at the ACG meeting at http://gi.org/media/press-releases-for-acg-annual-scientific-meeting/

Follow ACG on Twitter Tweet, Follow #ACG2012

American College of Gastroenterology

Related Gastroenterology Articles:

Baylor Scott & White gastroenterology researchers share key takeaways from DDW 2019
Dr. Stuart J. Spechler among researchers from Baylor Scott & White Research Institute available to provide key takeaways from Digestive Disease Week 2019.
The Lancet Gastroenterology & Hepatology: Colorectal cancer incidence on the rise among young adults in several high-income countries
The incidence of colon and rectal cancer in adults younger than 50 years has increased substantially over the latest available 10-year period in several high-income countries, going against a decline or stabilisation trend in the incidence of colorectal cancers within the overall populations of high-income countries.
The Lancet Gastroenterology & Hepatology and The Lancet Respiratory Medicine: Whole body MRI may help to detect spread of cancers more quickly
Trials with people with newly-diagnosed colorectal and non-small cell lung cancer suggest that whole body MRI could reduce the time it takes to diagnose the stage of cancers.
The Lancet Gastroenterology & Hepatology: Hypnotherapy could help relieve irritable bowel syndrome symptoms
Peer-reviewed / Randomised Controlled Trial / People Gut-directed hypnotherapy delivered by psychologists appears as effective in group or individual sessions, potentially offering a new treatment option for irritable bowel syndrome in primary and secondary care
Low FODMAP diet and IBS recently published by Dove Medical Press
The evidence to date indicates that restriction of FODMAPs is an effective dietary intervention for reducing IBS symptoms.
More Gastroenterology News and Gastroenterology Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...