Radiation therapy controls voicebox tumors and saves voice

October 23, 2000

Radiation therapy controls tumors of the voicebox almost as well as surgery, according to a new study at Washington University School of Medicine in St. Louis. The treatment also restores the quality of the voice.

Clifford K.S. Chao, M.D., assistant professor of radiology at the school's Mallinckrodt Institute of Radiology, will discuss these results Oct. 24 at the annual meeting of the American Society for Therapeutic Radiology and Oncology in Boston.

Cancer of the glottis--the voice-producing part of the larynx--usually is treated surgically with either hemilaryngectomy (removal of only half the larynx) or endoscopic resection (removal of the tumor by laser). But the researchers discovered that high-dose irradiation controlled tumors and preserved the voice almost as well as hemilaryngectomy. Endoscopic resection or low-dose radiation therapy were less effective the first time around, especially when patients had tumors on both sides of the head or neck.

Chao, Colin Painter, Ph.D., professor of otolaryngology, and colleagues studied patients with early stage tumors. Four hundred seventy-five underwent hemilaryngectomy, which controlled 92 percent of the very early stage tumors after two years follow-up.

One hundred twenty received high-dose radiation therapy, whose effectiveness was 89 percent. Sixty-one patients received endoscopic resection, which initially controlled only 77 percent of the tumors. The rate was 78 percent for the 137 people who received low-dose radiation.

Six months after treatment, the researchers assessed the voice quality of 25 patients who had received high-dose irradiation. They listened to the voice, made acoustic measurements and viewed the vocal cords with a video laryngoscope. They compared these patients with a control group of healthy individuals.

The patients sounded better and objective measurements of the quality of their voices were significantly higher than before irradiation, when their tumors greatly impaired their voices. "Radiation is almost equivalent to conservation surgery in cure rate, and quality of voice can be restored," Chao says.
Botero A, Chao KC, Duijndam I, Painter C, Fuller D, Spector JG, Sessions DG, Simpson JR, Perez CA, Haughey B.H. High dose radiation therapy yields satisfactory tumor control and the quality of voice as compared with those of hemilaryngectomy in early stage glottic carcinoma. Oral presentation at the annual meeting of the American Society for Therapeutic Radiology and Ocology. Oct. 22-26, 2000

The full-time and volunteer faculty of Washington University School of Medicine are the physicians and surgeons of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC Health System.

Washington University School of Medicine

Related Radiation Articles from Brightsurf:

Sheer protection from electromagnetic radiation
A printable ink that is both conductive and transparent can also block radio waves.

What membrane can do in dealing with radiation
USTC recently found that polymethylmethacrylate (PMMA) and polyvinyl chloride (PVC) can release acidic substance under γ radiation, whose amount is proportional to the radiation intensity.

First measurements of radiation levels on the moon
In the current issue (25 September) of the prestigious journal Science Advances, Chinese and German scientists report for the first time on time-resolved measurements of the radiation on the moon.

New biomaterial could shield against harmful radiation
Northwestern University researchers have synthesized a new form of melanin enriched with selenium.

A new way to monitor cancer radiation therapy doses
More than half of all cancer patients undergo radiation therapy and the dose is critical.

Nimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer
Oncotarget Volume 11, Issue 4: In this study, locally advanced head and neck cancer patients undergoing definitive chemoradiation were randomly allocated to weekly cisplatin - radiation {CRT arm} or nimotuzumab -weekly cisplatin -radiation {NCRT arm}.

Breaking up amino acids with radiation
A new experimental and theoretical study published in EPJ D has shown how the ions formed when electrons collide with one amino acid, glutamine, differ according to the energy of the colliding electrons.

Radiation breaks connections in the brain
One of the potentially life-altering side effects that patients experience after cranial radiotherapy for brain cancer is cognitive impairment.

Fragmenting ions and radiation sensitizers
The anti-cancer drug 5-fluorouracil (5FU) acts as a radiosensitizer: it is rapidly taken up into the DNA of cancer cells, making the cells more sensitive to radiotherapy.

'Seeing the light' behind radiation therapy
Delivering just the right dose of radiation for cancer patients is a delicate balance in their treatment regime.

Read More: Radiation News and Radiation Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.