Procedure to help Parkinson's disease could shed light on psychiatric disorder

October 24, 2002

French authors of a research letter in this week's issue of THE LANCET describe how electrode stimulation of a specific part of the brain to alleviate symptoms of Parkinson's disease could also help in the treatment of obsessive-compulsive disorders.

The psychiatric condition obsessive-compulsive disorder (OCD) is thought to be associated with alterations to specific nerve-cell circuits in the sub-cortical regions of the brain. Luc Mallet from CNRS UMR 7593 & INSERM U289 and colleagues implanted electrodes into the subthalamic nucleus to improve symptoms of Parkinson's disease in two patients who had a long history of OCD and a more recent history of Parkinson's disease. The first patient had OCD symptoms characterized by obsessive domestic cleaning and a fear of being found dead in a dirty house; the second patient was preoccupied by a checking of locks which took up to two hours a day.

Parkinsonian disability improved after electrode stimulation in both patients; 2 weeks after the procedure their compulsions had disappeared and obsessive symptoms had improved.

Luc Mallet comments: "Despite the partial efficacy of medical treatment, the management of patients with severe OCD remains a challenge. The recovery from OCD that we report in two patients with Parkinson's disease raises the possibility that high-frequency stimulation could improve the functions of subcortical limbic circuitry in patients with severe OCD."
Contact: Professor Yves Agid, Hopital de la Pitie-Salpetriere, 47 Bd de l'Hopital, 75651 Paris, Cedex 13, France;
T) 33-142-162-202;
F) 33-144-243-658 ;

Dr Luc MalletCNRS UMR 7593, Hopital de la Pitie-Salpetriere, 47 Bd de l'Hopital, 75651 Paris, Cedex 13, France;
T) 33-142-161-233;
F) 33-142-161-236;


Related Brain Articles from Brightsurf:

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

Children with asymptomatic brain bleeds as newborns show normal brain development at age 2
A study by UNC researchers finds that neurodevelopmental scores and gray matter volumes at age two years did not differ between children who had MRI-confirmed asymptomatic subdural hemorrhages when they were neonates, compared to children with no history of subdural hemorrhage.

New model of human brain 'conversations' could inform research on brain disease, cognition
A team of Indiana University neuroscientists has built a new model of human brain networks that sheds light on how the brain functions.

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.

Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.

An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.

Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.

Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.

Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.

Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.

Read More: Brain News and Brain Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to