Research selected for 2006 American College of Gastroenterology Governor's award

October 24, 2006

ROCHESTER, Minn. -- Studies led by Piet de Groen, M.D., and William Sandborn, M.D., of the Mayo Clinic Division of Gastroenterology and Hepatology, will be honored today at the American College of Gastroenterology Annual Scientific Meeting. Their work, in collaboration with other researchers, represents two of the five abstracts selected for the 2006 American College of Gastroenterology (ACG) Governor's Awards for Excellence in Clinical Research. Drs. de Groen and Sandborn will present their findings today at the ACG President's Plenary Session.

Groundbreaking Quality Control Work: Dr. de Groen's collaborative has developed a novel method to digitally capture, store, and analyze a complete video stream file created during colonoscopy. The software can automatically extract five quality measures from the digitized video files. "I'm not aware of any other software that can automatically analyze what a physician does during colonoscopy and provide objective data to the physician in a report. In other words, this is the first time a computer in completely automated fashion has been used to grade a procedure and thereby grade a physician," Dr. de Groen says.

Background: This collaborative began its work four years ago and is funded in part through a National Science Foundation grant for research of new methods of automated image analysis in endoscopy. The purpose of the research was to develop a method to gather objective data that could explain why large polyps and cancers are not always detected during colonoscopy. The researchers created approximately 250 digital video files during colonoscopy and extracted five objective quality control metrics using novel software.

Research Applications: Research applications include the potential to provide large-scale, continuous quality control for colonoscopy in the day-to-day medical practice setting and the ability to assess progress during colonoscopy training or as part of endoscopic skills assessment. Colonoscopy is the best diagnostic tool currently available for colon cancer detection and is recommended for everyone beginning at age 50.

Collaboration and Support: Others on the research team include JungHwan Oh, Ph.D., Department of Computer Science and Engineering, University of North Texas, Denton; Wallapak Tavanapong, Ph.D., and Johnny Wong, Ph.D., Department of Computer Science, Iowa State University, Ames. This work was supported in part by grants from the National Science Foundation, a Clinical Practice Innovation Award from Mayo Clinic, the Miles and Shirley Fiterman Endowment Fund for Digestive Diseases, the Grow Iowa Value Fund, and Iowa State University.

Alternative Option for Treating Crohn's Disease -- GAIN Study Design: Dr. Sandborn was the lead investigator of a multicenter study (GAIN -- gauging adalimumab efficacy in infliximab nonresponders) which found that a new drug, adalimumab (Humira), was able to induce clinical remission in patients with moderate to severe Crohn's disease who previously responded to infliximab (Remicade) and then became allergic or lost response. Infliximab is a chimeric (contains both mouse and human protein) monoclonal antibody to tumor necrosis factor (TNF). Adalimumab is a human (contains human protein only) monoclonal antibody to TNF. Because Adalimumab is structurally similar to naturally occurring human antibodies, it may be less likely to be rejected by the immune system.

A total of 325 patients with moderate to severe Crohn's disease participated in the four-week study which was conducted between November 2004 and December 2005. The patients were divided into two groups. One hundred and sixty-six patients were given a placebo and 159 patients were given 160 mg of adalimumab at week one and 80 mg the second week of the study.

Study Results:
Results of the GAIN Study, sponsored by Abbott Laboratories, show that adalimumab is an effective and safe alternative for patients. This positive effect was observed as early as week one. At week four, 21 percent of patients receiving adalimumab were in remission as compared with 7 percent of those who received the placebo. Response was induced at week four in 52 percent of patients in the adalimumab group as compared with 34 percent of patients in the placebo group. Adalimumab was well tolerated by the patients in the study, with an overall similar incidence of adverse events compared to those patients who received the placebo.

Impact of Research:
"The group of patients with the greatest medical need are those patients who have tried other treatment options with the exception of surgery," says Dr. Sandborn. "Our data indicate that adalimumab is a new effective and safe treatment option for these patients."
-end-
Collaboration and Support:
Other members of the collaborative are Paul Rutgeerts, M.D., Ph.D., Universitaire Ziekenhuizen Leuven, UZ Gasthuisberg, Leuven, Belgium; Robert Enns M.D., Gastroenterology Clinic, Vancouver, British Columbia, Canada; Stephen Hanauer M.D., University of Chicago; Jean Frederic Colombel M.D., L'hôpital Claude Huriez, Centre Hospitalier Universitare de Lille, France; Remo Panaccione, M.D., University of Calgary, Alberta, Canada; Jeffery Kent, M.D., Abbott Laboratories, Abbott Park, Ill.; and Paul Pollack, M.D., Abbott Laboratories, Parsippany, N.J.

To obtain the latest news releases from Mayo Clinic, go to www.mayoclinic.org/news. MayoClinic.com (www.mayoclinic.com) is available as a resource for your health stories.

Mayo Clinic

Related Colonoscopy Articles from Brightsurf:

Using robotic assistance to make colonoscopy kinder and easier
Scientists have made a breakthrough in their work to develop semi-autonomous colonoscopy, using a robot to guide a medical device into the body.

Nearly 1 in 8 patients receive unexpected out-of-network bills after colonoscopy
Nearly 1 in 8 commercially insured patients nationwide who underwent an elective colonoscopy between 2012 and 2017 performed by an in-network provider received potential 'surprise' bills for out-of-network expenses, often totaling hundreds of dollars or more.

Swallowing this colonoscopy-like bacteria grabber could reveal secrets about your health
Your gut bacteria could say a lot about you, such as why you're diabetic or how you respond to certain drugs.

Examining association between older age, risk of complications after colonoscopy
This observational study looked at the risk of complications after an outpatient colonoscopy among patients age 75 and older compared to younger patients.

Bowel cancer rates after colonoscopy vary by provider
A colonoscopy is the main test used to detect bowel cancer, but like most tests, it is not always 100% accurate and cancers can be missed.

Will disposable colonoscopy devices replace reusables?
As a disposable version of the instrument used in one of the most common medical procedures in the United States inches closer to widespread availability, a team of Johns Hopkins data researchers is studying the economic and safety implications associated with the devices used to perform colonoscopies.

Sedation method does not affect colonoscopy detection rate
Colon cancer is the second leading cause of cancer death in the United States and colonoscopy is the most-used screening tool to detect it.

Blue dye tablet helps identify polyps during colonoscopy
Ingestion of a blue dye tablet during bowel prep for colonoscopy could be a significant advance in the early detection of colorectal cancer (CRC).

Low complication rates after screening colonoscopy
During colonoscopy screening for bowel cancer and in the four weeks after the procedure, the risk for complications to develop is low.

Patients with positive fecal screening test, sooner is better for colonoscopy
The risk of colorectal cancer increased significantly when colonoscopy was delayed by more than nine months following a positive fecal screening test, according to a large Kaiser Permanente study published today in the Journal of the American Medical Association.

Read More: Colonoscopy News and Colonoscopy Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.