Nav: Home

Landmark study reveals no benefit to costly and risky brain cooling after brain injury

October 24, 2018

The study, published today, in the Journal of the American Medical Association and presented at the same time at the Congress of European Society of Intensive Care Medicine in Paris by lead authors, Professors Jamie Cooper and Alistair Nichol, looked at the outcomes for 511 patients across six countries who had traumatic brain injury (TBI).

An estimated 50-60 million people, worldwide, will suffer a TBI this year and more than half of the world's population will suffer at least one TBI during their lifetime. There has long been controversy around the benefits of brain cooling in the Intensive Care Unit following a TBI, in the belief the cooling or hypothermia reduces brain inflammation and consequent brain damage.

Professors Cooper, and Nichol, together with Lisa Higgins, and Tony Trapani, Dr Dashiell Gantner, Profs Michael Bailey, Stephen Bernard, Peter Cameron Jeffrey Rosenfeld and Andrew Forbes all from Monash, together with colleagues in Queensland, Western Australia, New Zealand, France, Qatar, and Saudi Arabia, divided the TBI patients into two groups: those that received hypothermia treatment as soon as possible post-injury, often in the ambulance on the way to an emergency department, and half who did not receive the therapy. The study, called POLAR (Prophylactic hypothermia to lessen traumatic brain injury) ran from seven years from 2010.

Patients in the hypothermia arm of the trial had their body temperatures reduced (firstly with cold saline provided intravenously in the ambulance and then with cold body wraps in emergency departments and ICUs for between 3 and 7 days post-injury).

According to Professor Cooper, who will present the results in Paris, the study definitively found there was no benefit to patients receiving hypothermia, as measured by their capacity to live independently following recovery from the TBI with 49% able to do so in both groups. "This study is the final word on whether hypothermia as a treatment for TBI works," Professor Cooper, who is also Director of the Australian and New Zealand Intensive Care (ANZIC) Research Centre, said.

Using hypothermia in the ICU not only requires valuable staff time but runs the risk of increased bleeding, increased risk of infection, and decreased heart rate and blood pressure, all of which have to be managed in a vulnerable patient. "From now on, patients should not have to endure the risks of hypothermia because we now know there are no benefits," Professor Cooper said.
-end-


Monash University

Related Traumatic Brain Injury Articles:

Reducing dangerous swelling in traumatic brain injury
After a traumatic brain injury (TBI), the most harmful damage is caused by secondary swelling of the brain compressed inside the skull.
Blue light can help heal mild traumatic brain injury
Daily exposure to blue wavelength light each morning helps to re-entrain the circadian rhythm so that people get better, more regular sleep which was translated into improvements in cognitive function, reduced daytime sleepiness and actual brain repair.
Dealing a therapeutic counterblow to traumatic brain injury
A team of NJIT biomedical engineers are developing a therapy which shows early indications it can protect neurons and stimulate the regrowth of blood vessels in damaged tissue.
Predictors of cognitive recovery following mild to severe traumatic brain injury
Researchers have shown that higher intelligence and younger age are predictors of greater cognitive recovery 2-5 years post-mild to severe traumatic brain injury (TBI).
Which car crashes cause traumatic brain injury?
Motor vehicle crashes are one of the most common causes of TBI-related emergency room visits, hospitalizations and deaths.
Traumatic brain injury and kids: New treatment guidelines issued
To help promote the highest standards of care, and improve the overall rates of survival and recovery following TBI, a panel of pediatric critical care, neurosurgery and other pediatric experts today issued the third edition of the Brain Trauma Foundation Guidelines for the Management of Pediatric Severe TBI.
Addressing sleep disorders after traumatic brain injury
Amsterdam, NL, December 10, 2018 - Disorders of sleep are some of the most common problems experienced by patients after traumatic brain injury (TBI).
Rutgers researchers discover possible cause for Alzheimer's and traumatic brain injury
Rutgers researchers discover a possible cause for Alzheimer's and traumatic brain injury, and the new mechanism may have also led to the discovery of an effective treatment.
Traumatic brain injury recovery via petri dish
Researchers in the University of Georgia's Regenerative Bioscience Center have succeeded in reproducing the effects of traumatic brain injury and stimulating recovery in neuron cells grown in a petri dish.
Traumatic brain injury may be associated with increased risk of suicide
An increased risk of suicide was associated with those residents of Denmark who sought medical attention for traumatic brain injury (TBI) compared with the general population without TBI in a study that used data from Danish national registers.
More Traumatic Brain Injury News and Traumatic Brain Injury Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Making Amends
What makes a true apology? What does it mean to make amends for past mistakes? This hour, TED speakers explore how repairing the wrongs of the past is the first step toward healing for the future. Guests include historian and preservationist Brent Leggs, law professor Martha Minow, librarian Dawn Wacek, and playwright V (formerly Eve Ensler).
Now Playing: Science for the People

#565 The Great Wide Indoors
We're all spending a bit more time indoors this summer than we probably figured. But did you ever stop to think about why the places we live and work as designed the way they are? And how they could be designed better? We're talking with Emily Anthes about her new book "The Great Indoors: The Surprising Science of how Buildings Shape our Behavior, Health and Happiness".
Now Playing: Radiolab

The Third. A TED Talk.
Jad gives a TED talk about his life as a journalist and how Radiolab has evolved over the years. Here's how TED described it:How do you end a story? Host of Radiolab Jad Abumrad tells how his search for an answer led him home to the mountains of Tennessee, where he met an unexpected teacher: Dolly Parton.Jad Nicholas Abumrad is a Lebanese-American radio host, composer and producer. He is the founder of the syndicated public radio program Radiolab, which is broadcast on over 600 radio stations nationwide and is downloaded more than 120 million times a year as a podcast. He also created More Perfect, a podcast that tells the stories behind the Supreme Court's most famous decisions. And most recently, Dolly Parton's America, a nine-episode podcast exploring the life and times of the iconic country music star. Abumrad has received three Peabody Awards and was named a MacArthur Fellow in 2011.