Stop the bleeding: New way to restore numbers of key blood-clotting cells

October 25, 2010

Platelets are cells in the blood that have a key role in stopping bleeding. Thrombocytopenia is the medical term used to describe the presence of abnormally low numbers of platelets in the blood. Platelet transfusion is used to treat several causes of thrombocytopenia, but there is a shortage of donors. Mortimer Poncz and colleagues, at Children's Hospital of Philadelphia, working with mice, have now identified a potential new approach to platelet replacement therapy that circumvents the problem of donor shortage.

Platelets in the blood arise from cells known as megakaryocytes. In the study, Poncz and colleagues found that mature megakaryocytes that were infused into mice could generate platelets of normal size and function. They therefore are hopeful that it might be possible to treat individuals with thrombocytopenia through mature megakaryocyte infusion, although they estimate that 10^9 mature megakaryocytes might be needed for an average 70-kg patient. Although Andrew Leavitt, at the University of California, San Francisco, notes in an accompanying commentary, that this might be a low estimate, he discuses why the new data generated by Poncz and colleagues are an important step forward in identifying new approaches to platelet replacement therapy.
-end-
TITLE: Infusion of mature megakaryocytes into mice yields functional platelets

AUTHOR CONTACT:
Mortimer Poncz
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Phone: 215.590.3574; Fax: 215.267.5476; E-mail: poncz@email.chop.edu.

View this article at: http://www.jci.org/articles/view/43326?key=70d31a6f7d6d4fe7c13f

ACCOMPANYING COMMENTARY
TITLE: Are there more tricks in the bag for treating thrombocytopenia?

AUTHOR CONTACT:
Andrew D. Leavitt
University of California at San Francisco, San Francisco, California, USA.
Phone: 415.514.3432; Fax: 415.514.3433; E-mail: leavitta@labmed2.ucsf.edu.

View this article at: http://www.jci.org/articles/view/45179?key=aed7bfaf9544a904a1d9

JCI Journals

Related Platelets Articles from Brightsurf:

Exploring connections between ovarian cancer and blood cells
Recent discoveries made by researchers at Texas A&M University could change the way ovarian cancer is understood and treated.

COVID-19 causes 'hyperactivity' in blood-clotting cells
Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious complications in some patients who have the disease, according to University of Utah Health scientists.

Novel function of platelets in tumor blood vessels found
Scientists at Uppsala University have discovered a hitherto unknown function of blood platelets in cancer.

Platelets exacerbate immune response
Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes.

Blood platelets trigger events that cause organ damage after heart surgery
Damage to kidneys and other organs after heart surgery is not so much triggered by the surgical repair of the heart itself but rather by the massive inflammatory response, which arises from multiple factors: the machinery used to keep blood and oxygen flowing, changes of blood flow during the surgery, and tissue responses to the surgical trauma.

Platelets instead of spheres make screens more economical
ETH scientists have further developed QLED technology for screens. They have produced light sources that for the first time emit high-intensity light in only one direction.

Study: Blood-clotting protein and blood platelets promote immune evasion, cancer progression
A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G.

Blocking platelets: A possible option to prevent fatty liver disease and liver cancer
Blood platelets which interact with liver cells and immune cells play a major role in the development of fatty liver disease, non-alcoholic fatty liver inflammation and liver cancer, scientists from the German Cancer Research Center (DKFZ) in Heidelberg and from Zurich University and University Hospital have now shown in a publication.

Platelet doppelgängers tackle thrombosis and cancer metastasis
Anne-Laure Papa and colleagues have created decoys of platelets -- the body's clot-forming blood cells -- that prevented the formation of dangerous blood clots in vessels (or thrombosis) and combated cancer metastasis in preclinical models.

Researchers develop reversible antiplatelet therapy to fight clotting, cancer metastasis
A new reversible, drug-free antiplatelet therapy could reduce the risk of blood clots and potentially prevent cancer metastasis, according to a study published today in Science Translational Medicine.

Read More: Platelets News and Platelets Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.