Nav: Home

High levels of estrogen in lung tissue related to lung cancer in postmenopausal women

October 25, 2016

Thanks to advances in medical imaging, the detection rate for synchronous multiple lung adenocarcinoma (SMLA) has been on the rise. Cases of SMLA in Japanese women have been on the rise despite having a national smoking rate of less than 10% in recent years. This suggests that SMLA is influenced by something other than smoking and, indeed, several studies have found that estrogen is involved in lung cancer carcinogenesis.

A research team from Kumamoto University set out to determine if there was a relationship between the concentration of estrogen in lung tissue and multiple primary lung cancers in postmenopausal women. To do this, they compared estrogen concentrations in non-cancerous peripheral lung tissue of postmenopausal women who were diagnosed with SMLA to the concentrations found in women with single tumor lung adenocarcinoma (AD). The experiment consisted of two groups, 30 SMLA patients and 79 AD patients, with similar clinical characteristics.

Researchers measured estrone (E1), the main form of estrogen in postmenopausal females, and estradiol (E2), the primary female sex hormone during reproductive years, in the non-cancerous lung tissues of each group and found both forms of estrogen were higher in SMLA patients than in AD patients. Furthermore, neither estrogens in either experimental group were found to be associated with the confounding factors of age, smoking status, cancer stage, family cancer history or mutation in the epidermal growth factor receptor (EGFR).

"We were also able to ascertain that an allele of the single nucleotide polymorphism (SNP) rs3764221 in the CYP19A1 gene was associated with a risk for SMLA, which was consistent with our previous research," said Assistant Professor Koei Ikeda, who led the project. "The locally elevated expression of this gene in the peripheral lung was also correlated to the concentration of estrogen in the same area. An SNP in CYP19A1 could be causing the increased estrogen increase. Perhaps, with further research, we will be able to develop a gene therapy that would reduce the estrogen concentration caused by the SNP."
-end-
This research and supplementary data can be found in the journal PLOS ONE at: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0160910



[Citation]


Ikeda K, Shiraishi K, Yoshida A, Shinchi Y, Sanada M, Motooka Y, et al. (2016) Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung. PLoS ONE 11(8): e0160910. doi:10.1371/journal.pone.0160910

Kumamoto University

Related Smoking Articles:

Smoking rates falling in adults, but stroke survivors' smoking rates remain steady
While the rate of Americans who smoke tobacco has fallen steadily over the last two decades, the rate of stroke survivors who smoke has not changed significantly.
What is your risk from smoking? Your network knows!
A new study from researchers at Penn's Annenberg School for Communication found that most people, smokers and non-smokers alike, were nowhere near accurate in their answers to questions about smoking's health effects.
Want to quit smoking? Partner up
Kicking the habit works best in pairs. That's the main message of a study presented today at EuroPrevent 2019, a scientific congress of the European Society of Cardiology (ESC).
Smoking and mortality in Asia
In this analysis of data from 20 studies conducted in China, Japan, South Korea, Singapore, Taiwan and India with more than 1 million participants, deaths associated with smoking continued to increase among men in Asia grouped by the years in which they were born.
Predictors of successfully quitting smoking among smokers registered at the quit smoking clinic at a public hospital in northeastern Malaysia
In the current issue of Family Medicine and Community Health, Nur Izzati Mohammad et al. consider how cigarette smoking is one of the risk factors leading to noncommunicable diseases such as cardiovascular and respiratory system diseases and cancer.
Restaurant and bar smoking bans do reduce smoking, especially among the highly educated
Smoking risk drops significantly in college graduates when they live near areas that have completely banned smoking in bars and restaurants, according to a new study in the American Journal of Epidemiology.
How the UK smoking ban increased wellbeing
Married women with children reported the largest increase in well-being following the smoking bans in the UK in 2006 and 2007 but there was no comparable increase for married men with children.
Smoking study personalizes treatment
A simple blood test is allowing Vanderbilt University Medical Center (VUMC) researchers to determine which patients should be prescribed varenicline (Chantix) to stop smoking and which patients could do just as well, and avoid side effects, by using a nicotine patch.
A biophysical smoking gun
While much about Alzheimer's disease remains a mystery, scientists do know that part of the disease's progression involves a normal protein called tau, aggregating to form ropelike inclusions within brain cells that eventually strangle the neurons.
A case where smoking helped
A mutation in the hemoglobin of a young woman in Germany was found to cause her mild anemia.
More Smoking News and Smoking Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Making Amends
What makes a true apology? What does it mean to make amends for past mistakes? This hour, TED speakers explore how repairing the wrongs of the past is the first step toward healing for the future. Guests include historian and preservationist Brent Leggs, law professor Martha Minow, librarian Dawn Wacek, and playwright V (formerly Eve Ensler).
Now Playing: Science for the People

#566 Is Your Gut Leaking?
This week we're busting the human gut wide open with Dr. Alessio Fasano from the Center for Celiac Research and Treatment at Massachusetts General Hospital. Join host Anika Hazra for our discussion separating fact from fiction on the controversial topic of leaky gut syndrome. We cover everything from what causes a leaky gut to interpreting the results of a gut microbiome test! Related links: Center for Celiac Research and Treatment website and their YouTube channel
Now Playing: Radiolab

The Flag and the Fury
How do you actually make change in the world? For 126 years, Mississippi has had the Confederate battle flag on their state flag, and they were the last state in the nation where that emblem remained "officially" flying.  A few days ago, that flag came down. A few days before that, it coming down would have seemed impossible. We dive into the story behind this de-flagging: a journey involving a clash of histories, designs, families, and even cheerleading. This show is a collaboration with OSM Audio. Kiese Laymon's memoir Heavy is here. And the Hospitality Flag webpage is here.