U of MN Center for Drug Design awarded $2.5 million grant

October 26, 2006

The University of Minnesota Center for Drug Design has been awarded a $2.5 million, 5-year grant by the National Institute of Health (NIH) to research antidotes for cyanide poisoning. The study, Countermeasures Against Chemical Threats: Countermeasures Against Cyanide, will be led by Herbert Nagasawa, Ph.D., Robert Vince, Ph.D., and Steve Patterson, Ph.D.

Cyanide poisoning has the potential to be an intentional threat, as a weapon of mass destruction, or an accidental threat, through laboratory exposure, medical crisis, or smoke inhalation of fire victims. There are currently treatments that can be used to fight cyanide poisoning but they are slow acting and can have serious complications. The U.S. Army Medical Research Institute for Chemical Defense says that in order to effectively intervene in cyanide poisoning, a fast acting "three-minute solution" is necessary. One goal of better treatments is to produce a phophylactic agent that can be taken before the threat of a cyanide attack.

The Center for Drug Design has already developed a series of antidotes that can convert cyanide into a nontoxic substance through the use of a cellular enzyme. These antidotes are quicker than current treatment and can be delivered either orally or intravenously. This study aims to expand the efficiency, bioavailability, and physical properties of these antidotes, to seek specific substances to improve the neurological problems for long-term survivors of acute cyanide poisoning, and to begin preclinical studies that will lead to filing an application with the FDA for an investigational new drug (IND).

University of Minnesota

Related Health Articles from Brightsurf:

The mental health impact of pandemics for front line health care staff
New research shows the impact that pandemics have on the mental health of front-line health care staff.

Modifiable health risks linked to more than $730 billion in US health care costs
Modifiable health risks, such as obesity, high blood pressure, and smoking, were linked to over $730 billion in health care spending in the US in 2016, according to a study published in The Lancet Public Health.

New measure of social determinants of health may improve cardiovascular health assessment
The authors of this study developed a single risk score derived from multiple social determinants of health that predicts county-level cardiovascular disease mortality.

BU study: High deductible health plans are widening racial health gaps
The growing Black Lives Matter movement has brought more attention to the myriad structures that reinforce racial inequities, in everything from policing to hiring to maternal mortality.

Electronic health information exchange improves public health disease reporting
Disease tracking is an important area of focus for health departments in the midst of the COVID-19 pandemic.

E-health resource improves men's health behaviours with or without fitness facilities
Men who regularly used a free web resource made significantly more health changes than men who did not, finds a new study from the University of British Columbia and Intensions Consulting.

Mental health outcomes among health care workers during COVID-19 pandemic in Italy
Symptoms of posttraumatic stress disorder, depression, anxiety and insomnia among health care workers in Italy during the COVID-19 pandemic are reported in this observational study.

Mental health of health care workers in china in hospitals with patients with COVID-19
This survey study of almost 1,300 health care workers in China at 34 hospitals equipped with fever clinics or wards for patients with COVID-19 reports on their mental health outcomes, including symptoms of depression, anxiety, insomnia and distress.

Health records pin broad set of health risks on genetic premutation
Researchers from the University of Wisconsin-Madison and Marshfield Clinic have found that there may be a much broader health risk to carriers of the FMR1 premutation, with potentially dozens of clinical conditions that can be ascribed directly to carrying it.

Attitudes about health affect how older adults engage with negative health news
To get older adults to pay attention to important health information, preface it with the good news about their health.

Read More: Health News and Health Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.