High-risk carotid artery plaque formation is increased in older COPD patients

October 26, 2012

Older patients with chronic obstructive pulmonary disease (COPD) are at increased risk for carotid artery plaque formation and for the presence of vulnerable plaques with a lipid core, according to a new study from researchers in the Netherlands.

"We know that COPD is a risk factor for ischemic stroke, and that certain components of carotid artery plaques such as intraplaque hemorrhage and lipid core increase the risk of ischemic events, but plaque composition in patients with COPD has not been examined," said researcher Bruno H.C. Stricker, MD, PhD, professor of pharmaco-epidemiology at the Erasmus Medical Center in Rotterdam, the Netherlands. "In our study, carotid artery wall thickening was increased twofold in older COPD patients compared with controls with normal lung function, and COPD was an independent predictor of the presence of plaques with a lipid core, which are more prone to rupture."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The cross-sectional study, part of the Rotterdam Study, an ongoing population-based cohort study examining the occurrence of and risk factors for chronic diseases in subjects aged 55 years and older, involved 253 COPD patients and 920 controls. COPD was confirmed by spirometry. Subjects with carotid wall thickening (intima-media thickness ≥ 2.5 mm) on ultrasonography underwent high-resolution magnetic resonance imaging (MRI) to characterize carotid plaques.

Subjects with COPD had a twofold increased risk (odds ratio 2.0, 95%CI 1.44-2.85, p<0.0001) of carotid wall thickening on ultrasonography compared to controls, and this risk increased significantly with the severity of airflow limitation. On MRI, vulnerable lipid core plaques were significantly more frequent in subjects with COPD compared with controls (odds ratio 2.1, 95%CI 1.25-3.69, p=0.0058).

"Clinicians should be aware that COPD patients are at increased risk for asymptomatic carotid atherosclerosis and that COPD might lead to vulnerable plaques by inducing or aggravating the presence of plaques with a lipid core," said Dr. Stricker.

The study had a few limitations, including the study's cross-sectional design, which doesn't allow causal associations between COPD and carotid plaques to be inferred, and the lack of computed tomography confirmation of emphysema

"The results of our study provide new insights into the relationship between COPD and the increased risk for stroke seen in these patients," concluded Dr. Stricker. "Understanding the underlying risk factors for stroke in COPD patients can help identify those at high risk and lead to the development of more personalized preventive treatment strategies targeting this devastating complication."
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About the American Journal of Respiratory and Critical Care Medicine:

With an impact factor of 11.080, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields. Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.

American Thoracic Society

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