Heart rate, blood pressure in male teens associated with later risk for psychiatric disorders

October 26, 2016

Higher resting heart rate and higher blood pressure in late adolescence were associated with an increased risk in men for the subsequent development of obsessive-compulsive disorder, schizophrenia and anxiety disorders, according to a new article published online by JAMA Psychiatry.

Autonomic nervous system functioning regulates the inner workings of the body. Besides resting heart rate, changes in blood pressure, regulated by the autonomic nervous system, have been observed in some patients with psychiatric disorders but the results have been inconsistent.

Antti Latvala, Ph.D., of the University of Helsinki, Finland, and coauthors used register data for more than 1 million men in Sweden whose resting heart rate and blood pressure were measured at military conscription (average age 18) from 1969 to 2010 to examine whether differences in cardiac autonomic function were associated with psychiatric disorders.

Analyses based on up to 45 years of follow-up data suggest men in their late teens with resting heart rates above 82 beats per minute had a 69 percent increased risk for later obsessive-compulsive disorder (OCD), a 21 percent increased risk for schizophrenia and an 18 percent increased risk for anxiety disorders compared with those whose resting heart rates were below 62 beats per minute. The authors report similar associations for blood pressure.

Lower resting heart rate and blood pressure were associated with substance use disorders and violent behavior, the study also reports.

The authors note their results cannot establish causality.

"These associations should be confirmed in other longitudinal studies, and the underlying mechanisms should be studied with more detailed measures of autonomic functioning and designs that can more clearly elucidate causal processes," the article concludes.
-end-
(JAMA Psychiatry. Published online October 26, 2016. doi:10.1001/ jamapsychiatry.2016.2717. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: The article contains conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

To place an electronic embedded link to this study in your story Link will be live at the embargo time: http://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2016.2717

The JAMA Network Journals

Related Schizophrenia Articles from Brightsurf:

Schizophrenia: When the thalamus misleads the ear
Scientists at the University of Geneva (UNIGE) and the Synapsy National Centre of Competence in Research (NCCR) have succeeded in linking the onset of auditory hallucinations - one of the most common symptoms of schizophrenia - with the abnormal development of certain substructures of a region deep in the brain called the thalamus.

Unlocking schizophrenia
New research, led by Prof. LIU Bing and Prof. JIANG Tianzi from the Institute of Automation of the Chinese Academy of Sciences and their collaborators have recently developed a novel imaging marker that may help in the personalized medicine of psychiatric disorders.

Researchers discover second type of schizophrenia
In a study of more than 300 patients from three continents, over one third had brains that looked similar to healthy people.

New clues into the genetic origins of schizophrenia
The first genetic analysis of schizophrenia in an ancestral African population, the South African Xhosa, appears in the Jan.

Dietary supplement may help with schizophrenia
A dietary supplement, sarcosine, may help with schizophrenia as part of a holistic approach complementing antipsychotic medication, according to a UCL researcher.

Schizophrenia: Adolescence is the game-changer
Schizophrenia may be related to the deletion syndrome. However, not everyone who has the syndrome necessarily develops psychotic symptoms.

Study suggests overdiagnosis of schizophrenia
In a small study of patients referred to the Johns Hopkins Early Psychosis Intervention Clinic (EPIC), Johns Hopkins Medicine researchers report that about half the people referred to the clinic with a schizophrenia diagnosis didn't actually have schizophrenia.

The ways of wisdom in schizophrenia
Researchers at UC San Diego School of Medicine report that persons with schizophrenia scored lower on a wisdom assessment than non-psychiatric comparison participants, but that there was considerable variability in levels of wisdom, and those with higher scores displayed fewer psychotic symptoms.

Recognizing the uniqueness of different individuals with schizophrenia
Individuals diagnosed with schizophrenia differ greatly from one another. Researchers from Radboud university medical center, along with colleagues from England and Norway, have demonstrated that very few identical brain differences are shared amongst different patients.

Resynchronizing neurons to erase schizophrenia
Today, a decisive step in understanding schizophrenia has been taken.

Read More: Schizophrenia News and Schizophrenia Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.