Yale scientists participate in $12.3M NIH National Technology Center

October 27, 2005

New Haven, Conn. -- Two Yale scientists are part of the research team receiving $12.3 million, five-year grant as part of the National Institutes of Health (NIH) Roadmap for Medical Research supporting multidisciplinary projects to accelerate progress in medical research on how cells interact with their environments.

The team of 17 cell biologists and physical scientists including, Yale faculty members Eric R. Dufresne, assistant professor of mechanical engineering, chemical engineering and physics and Thomas D. Pollard, Chair and Higgins Professor of Molecular, Cellular & Developmental Biology; will develop methods to quantitatively measure, model, and manipulate live cells.

Leslie M. Loew, professor of cell biology at the University of Connecticut Health Center is the principal investigator for the grant, which is one of only five National Technology Centers for Networks and Pathways.

The three core technology projects are designed to study how cells control the location of their molecular components and how that distribution is used to optimize cell functions. Wound healing and muscle contraction are examples of biological processes that rely on interacting pathways and communication among genes, proteins and cells.

"Our group is developing non-invasive methods for manipulating matter with light. We use our Holographic Optical Tweezer (HOT) systems to trap, pull, position, and twist up to about one hundred microparticles simultaneously," said Dufresne. "We will stimulate individual cells with precisely coordinated biochemical and mechanical signals to quantify their dynamic response. Using multiple probes together, we will be able to measure cooperative effects in cell signaling."

Pollard's team will use calibrated fluorescent microscopy to quantify precisely the number and physical arrangement of actin molecules at the leading edge of single-celled amoebas as they move. "Investigating different aspects of polarity in diverse systems will let us discover common themes that reveal the fundamental principles," he said.

"By focusing on biomedical problems and issues, we ensure that the new technologies we develop will ultimately have a positive impact on health," says Loew.
-end-


Yale University

Related Cell Biology Articles from Brightsurf:

Deep learning on cell signaling networks establishes AI for single-cell biology
Researchers at CeMM have developed knowledge-primed neural networks (KPNNs), a new method that combines the power of deep learning with the interpretability of biological network models.

RNA biology provides the key to cell identity and health
Two papers in Genome Research by the FANTOM Consortium have provided new insights into the core regulatory networks governing cell types in different vertebrate species, and the role of RNA as regulators of cell function and identity.

Cell biology: Your number's up!
mRNAs program the synthesis of proteins in cells, and their functional lifetimes are dynamically regulated.

Cell biology -- maintaining mitochondrial resilience
Mitochondria cannot autonomously cope with stress and must instead call on the cell for help.

Cell biology: All in a flash!
Scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich have developed a tool to eliminate essential proteins from cells with a flash of light.

A biology boost
Assistance during the first years of a biology major leads to higher retention of first-generation students.

Cell-free synthetic biology comes of age
In a review paper published in Nature Reviews Genetics, Professor Michael Jewett explores how cell-free gene expression stands to help the field of synthetic biology dramatically impact society, from the environment to medicine to education.

Scientists develop electrochemical platform for cell-free synthetic biology
Scientists at the University of Toronto (U of T) and Arizona State University (ASU) have developed the first direct gene circuit to electrode interface by combining cell-free synthetic biology with state-of-the-art nanostructured electrodes.

In a first for cell biology, scientists observe ribosome assembly in real time
A team of scientists from Scripps Research and Stanford University has recorded in real time a key step in the assembly of ribosomes -- the complex and evolutionarily ancient 'molecular machines' that make proteins in cells and are essential for all life forms.

Cell biology: Endocannabinoid system may be involved in human testis physiology
The endocannabinoid system (ECS) may be directly involved in the regulation of the physiology of the human testis, including the development of sperm cells, according to a study in tissue samples from 15 patients published in Scientific Reports.

Read More: Cell Biology News and Cell Biology Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.