Even in middle age, cutting calories slows aging of the heart

October 28, 2002

MADISON - To remain young at heart, eat less.

That, in short, is the message drawn from research published today, Oct. 28, by a team of researchers from the University of Wisconsin-Madison. Writing in the Proceedings of the National Academy of Sciences (PNAS), a research group led by UW-Madison genetics Professor Tomas A. Prolla, and Medical School Professor Richard Weindruch, reports the results of a study in which middle-aged mice, put on a calorie-restricted diet, exhibit signs of a remarkable uptick in heart health in old age. "It looks like caloric restriction just retarded the whole aging process in the heart," said Prolla whose group employed powerful molecular techniques to study nearly 10,000 genes at work in the heart. The work represents the first global analysis of gene expression in the aging heart.

University of Wisconsin-Madison

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