Alaska avian flu project issues initial surveillance results

October 28, 2005

FAIRBANKS, Alaska -- So far, so good. Although only a few of the results are in, the University of Alaska Program on the Biology and Epidemiology of Avian Influenza in Alaska reports today that none of the samples taken from migratory waterfowl in the state this summer and screened to date have tested positive for the deadly H5N1 strain of bird flu virus being reported in Eurasia. Next summer the news may not be so good.

Alaska is at the overlap for parts of the Asian and North American flyways for migratory birds which scientists say could provide an opportunity for exchange of bird flu viruses which then could lead to the evolution of new strains of viruses that could infect humans.

Scientists at the University of Alaska Fairbanks formed the Avian Influenza Program to study the evolution and assess the prevalence of the many different avian influenza viruses in Alaska, including the highly disease-causing (pathogenic), H5N1 Asian subtype, in migratory birds. Researchers from UAF and collaborators from state, federal and private wildlife and public health agencies obtained cloacal samples from birds in the Minto Flats, Yukon Flats and Yukon Delta National Wildlife Refuges, Copper River Delta and other areas in the state this year.

Of the roughly 4,500 samples collected, 290 have been screened to determine the presence of any of the known subtypes of avian influenza virus. Thirty of the 290 samples tested positive for various bird flu viruses, but none of the viral isolation and subtyping to date has detected H5N1. The sample results will provide early detection for 2005 and baseline data for 2006 and subsequent years, which UAF researchers and others can use for compare to future samples and from which they hope to build predictive models of how the viruses mutate and move in the environment.

"With a virus like H5N1 emerging in an area like Southeast Asia and spreading toward Europe if it doesn't reach Alaska this year, those birds that go back may very well pick it up and bring it to Alaska next year to an environment where that H5N1 might mix with other strains it hasn't seen before," said Jonathan Runstadler, a lead scientist on the project, assistant professor of biology and wildlife at UAF's Institute of Arctic Biology and a veterinarian.

"I think we did a good job for this year in what we set out to do -- getting samples from various parts of the state and from a variety of different species, but there are areas of the state we didn't cover, particular sites and species we could use samples from," Runstadler said.

"We're trying to understand the evolution and prevalence of all avian influenza viruses in wild birds, not just H5N1 -- everybody knows birds are where these viruses come from but no one knows how they get from birds to humans," said George Happ, director of the IDeA Network for Biomedical Research Excellence at UAF, which provided start-up funding for the project. "We want to identify what genetic changes are important when a normally benign virus becomes a pathogen."

The 1918 influenza virus which caused one of history's most deadly epidemics -- an estimated 50 million people died and almost half of those who died were healthy, young adults -- was identified in October 2005 as a bird flu that jumped directly to humans. According to the National Institutes of Health, the virus currently circulating in Asia, a strain of the H5N1 subtype, has acquired five of the 10 gene sequence changes associated with the human-to-human transmission of the 1918 virus.

Alaska's samples are being screened by Jeffrey Taubenberger the scientist who extracted and pieced together the viral genes from a lung-tissue sample obtained from a woman who had died in Brevig Mission, Alaska. When influenza swept through the village in 1918 it killed all but a handful of people. Taubenberger, of the Armed Forces Institute of Pathology, was also a member of one of the two teams of scientists who reported in October 2005 that the 1918 influenza was a bird flu that jumped to people.

Jonathan Runstadler, Assistant Professor of Biology and Wildlife, Institute of Arctic Biology and Department of Biology and Wildlife, UAF, 907.474.7038,

George Happ, Director Alaska IDeA Networks for Biomedical Research Excellence, UAF, 907.474.5492,

Marie Gilbert, Publications and Information Coordinator, Institute of Arctic Biology, UAF, 907.474.7412,

Avian Influenza Web sites:

Alaska IDeA Network for Biomedical Research Excellence (UAF):

U.S. Centers for Disease Control avian influenza fact sheet:

World Health Organization avian influenza fact sheet:

University of Alaska Fairbanks

Related Evolution Articles from Brightsurf:

Seeing evolution happening before your eyes
Researchers from the European Molecular Biology Laboratory in Heidelberg established an automated pipeline to create mutations in genomic enhancers that let them watch evolution unfold before their eyes.

A timeline on the evolution of reptiles
A statistical analysis of that vast database is helping scientists better understand the evolution of these cold-blooded vertebrates by contradicting a widely held theory that major transitions in evolution always happened in big, quick (geologically speaking) bursts, triggered by major environmental shifts.

Looking at evolution's genealogy from home
Evolution leaves its traces in particular in genomes. A team headed by Dr.

How boundaries become bridges in evolution
The mechanisms that make organisms locally fit and those responsible for change are distinct and occur sequentially in evolution.

Genome evolution goes digital
Dr. Alan Herbert from InsideOutBio describes ground-breaking research in a paper published online by Royal Society Open Science.

Paleontology: Experiments in evolution
A new find from Patagonia sheds light on the evolution of large predatory dinosaurs.

A window into evolution
The C4 cycle supercharges photosynthesis and evolved independently more than 62 times.

Is evolution predictable?
An international team of scientists working with Heliconius butterflies at the Smithsonian Tropical Research Institute (STRI) in Panama was faced with a mystery: how do pairs of unrelated butterflies from Peru to Costa Rica evolve nearly the same wing-color patterns over and over again?

Predicting evolution
A new method of 're-barcoding' DNA allows scientists to track rapid evolution in yeast.

Insect evolution: Insect evolution
Scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have shown that the incidence of midge and fly larvae in amber is far higher than previously thought.

Read More: Evolution News and Evolution Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to