Scientists are developing a way to counter ulcerative colitis

October 28, 2019

Scientists from 34 countries with an IKBFU researcher among them are working on a medicine for the treatment of ulcerative colitis.

IKBFU center for clinical research scientists have participated in the international VARSITY clinical research. It's the world's first research aimed at finding the most effective drug among anti-inflammatory ones for the treatment of ulcerative colitis. Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The disease can cause severe complications, starting with fistula in neighboring internal organs with a risk of peritonitis and ending with malignant neoplasms. The research was carried out in 245 research centers of 34 countries (19 Russian centers were among them). There were 771 patients aged from 18 to 85 years, with moderate and severe forms of ulcerative colitis.

Prof. Vladimir Rafalskiy, director of the IKBFU center for clinical research said: 15 years ago our opportunities in treating ulcerative colitis were quite limited. Doctors only had to use hormones glucocorticoids, the drug azathioprine, and salicylic acid derivatives. There were only three groups of drugs and the effectiveness of those groups was far from what was expected by doctors and patients alike. But the pharmacological science moves on and about ten years ago a new type of drugs was created. This is an innovative bio-genetic drug, producing antibodies blocking inflammation molecules and allowing very effective control of ulcerative colitis".

Today's pharmaceutical market offers patients with ulcerative colitis five drugs from the group of inhibitors of tumor necrosis factor and one anti-integrin drug. These are effective in treating the disease, especially in comparison with earlier drugs. Interestingly, the new generation drugs have never been compared.

Prof. Rafalskiy said:

"This is the first time when two new drugs are being compared. One of the drugs is an inhibitor of tumor necrosis factor and the other is an anti-integrin drug. The research was conducted from 2015 to 2019. The patients were randomly divided into two groups with different drugs (adalimumab and vedolizumab )administered to each group. There were several criteria for the research: clinical efficacy, the manifestation of the symptoms of the disease (participants filled in electronic diaries indicating the frequency of defecation, bleeding, abdominal pain, etc.), the results of colonoscopy before and after therapy, the results of histological examination, etc. The research has shown that vedolizumab is 9-12% more effective. And this difference is important for the treatment of ulcerative colitis. "
The results were published in the medical journal "The New England Journal of Medicine". Researchers from Icahn School of Medicine at Mount Sinai (New York, USA), Nancy University Hospital (Nancy, France), Mayo Clinic College of Medicine (Minnesota, USA), Ankara University School of Medicine (Ankara, Turkey), Takeda Development Center Europe (London, UK), University Hospital Schleswig-Holstein (Kiel, Germany).

Immanuel Kant Baltic Federal University

Related Inflammation Articles from Brightsurf:

3D printed stents that treat inflammation
POSTECH Professor Dong-Woo Cho's research team develops bioink-loaded esophageal stents for treating radiation esophagitis.

New cause of inflammation in people with HIV identified
A new study led by researchers at Boston Medical Center examined what factors could be contributing to this inflammation, and they identified the inability to control HIV RNA production from existing HIV DNA as a potential key driver of inflammation.

Maltreatment tied to higher inflammation in girls
New research by a University of Georgia scientist reveals that girls who are maltreated show higher levels of inflammation at an early age than boys who are maltreated or children who have not experienced abuse.

A protein that controls inflammation
A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.

Inflammation in the brain linked to several forms of dementia
Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge.

Social isolation could cause physical inflammation
Social isolation could be associated with increased inflammation in the body new research from the University of Surrey and Brunel University London has found.

Hydrogels control inflammation to help healing
Researchers test a sampling of synthetic, biocompatible hydrogels to see how tuning them influences the body's inflammatory response.

Why beta-blockers cause skin inflammation
Beta-blockers are often used to treat high blood pressure and other cardiovascular diseases.

The 'inflammation' of opioid use
New research correlates inflammation in the brain and gut to negative emotional state during opioid withdrawal.

Using a common anticonvulsant to counteract inflammation
The interaction between a chromosomal protein called HMGB1 and a cellular receptor called RAGE is known to trigger inflammation.

Read More: Inflammation News and Inflammation Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to