University of Pennsylvania study shows cardioprotective benefits of aspirin inhibited when preceded by ibuprofen

October 29, 2000

Philadelphia -- A study conducted at the University of Pennsylvania Medical Center suggests that ibuprofen (Motrin™, Advil™), when taken before aspirin, can inhibit the cardioprotective benefits gained from a daily aspirin regimen. These results are being presented at the annual meeting of the American College of Rheumatology on Wednesday, November 1, 2000, in Philadelphia.

Aspirin is known to exert cardioprotective benefits through the irreversible inhibition of cyclooxygenase - preventing blood clot formation. "The study was designed to establish whether the cardioprotective benefits of aspirin may be affected by the timing of coincidental therapy with either a conventional pain killer, Ibuprofen (Motrin™, Advil™), a new medication for arthritis, Rofecoxib (Vioxx™), or Acetominophen (Tylenol™)," explains Dr. Francesca Catella-Lawson, clinical pharmacologist at the University of Pennsylvania Medical Center and lead investigator on the study.

Volunteers in the study were divided into three cohorts. Cohort A received ibuprofen prior to aspirin for six days and aspirin prior to ibuprofen for the other six days. Patients who took ibuprofen first showed a full recovery of cyclooxygenase inhibition after 24 hours -- suggesting aspirin was unable to interact with cyclooxygenase in these patients. The reverse occurred when patients took aspirin first. "Aspirin's unique cardioprotective benefits are helping save thousands of lives. We want to insure that people are not losing cardiac protection by taking competing medications prior to aspirin," states Garret FitzGerald, MD, chair of Pharmacology at the University of Pennsylvania and another lead investigator on the study.

Tylenol™ and Vioxx™, two other medications commonly used for arthritis, were similarly tested in the two other Cohorts. Both groups showed no competitive interaction with aspirin.
This study was funded by the Bayer Corporation, of which, Drs. Catella-Lawson and FitzGerald hold no financial interest.

University of Pennsylvania School of Medicine

Related Arthritis Articles from Brightsurf:

Physical activity and sleep in adults with arthritis
A new study published in Arthritis Care & Research has examined patterns of 24-hour physical activity and sleep among patients with rheumatoid arthritis, lupus, and knee osteoarthritis.

Is rheumatoid arthritis two different diseases?
While disease activity improves over time for most rheumatoid arthritis (RA) patients, long-term outcomes only improve in RA patients with autoantibodies, according to a new study published this week in PLOS Medicine by Xanthe Matthijssen of Leiden University Medical Center, Netherlands, and colleagues.

Does the Mediterranean diet protect against rheumatoid arthritis?
Previous research has demonstrated a variety of health benefits associated with the Mediterranean diet, which is rich in olive oil, cereals, fruit and vegetables, fish, and a moderate amount of dairy, meat, and wine.

Reducing corticosteroid use in rheumatoid arthritis
Is the long-term use of glucocorticoids essential in people with chronic inflammatory diseases such as rheumatoid arthritis, or can early discontinuation prevent characteristic side effects?

Psoriasis onset determines if psoriatic arthritis patients develop arthritis or psoriasis first
In a new study presented at the 2019 ACR/ARP Annual Meeting, researchers found the age of psoriasis onset determines whether arthritis or psoriasis starts first in people with psoriatic arthritis.

The ACR and the Arthritis Foundation present new guidelines offering therapeutic approaches and treatment options for juvenile idiopathic arthritis
Today, the American College of Rheumatology (ACR), in partnership with the Arthritis Foundation (AF), released two guidelines on juvenile idiopathic arthritis (JIA).

Does alcohol consumption have an effect on arthritis?
Several previous studies have demonstrated that moderate alcohol consumption is linked with less severe disease and better quality of life in patients with rheumatoid arthritis, but a new Arthritis Care & Research study suggests that this might not be because drinking alcohol is beneficial.

Prospect of a new treatment for rheumatoid arthritis
An international research group led by Charité -- Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.

Can rare lymphocytes combat rheumatoid arthritis?
Immunologists at Friedrich-Alexander-Universität Erlangen-Nürnberg have demonstrated that ILC2, a group of rare lymphoid cells, play a key role in the development of inflammatory arthritis.

Which pain medication is safest for arthritis patients?
In a recent Alimentary Pharmacology & Therapeutics study, arthritis patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) for pain plus a stomach acid-reducing medicine called esomeprazole had infrequent gastrointestinal side effects.

Read More: Arthritis News and Arthritis Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to