Earlier not necessarily better when receiving a kidney transplant

October 29, 2009

Pre-dialysis transplant recipients with a high level of kidney function don't benefit from their transplant more than pre-dialysis recipients with low level kidney function, according to a paper being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA. The findings indicate that there may be no urgency for kidney disease patients to get a transplant while their kidneys are still somewhat healthy.

Kidney disease patients with pre-dialysis transplants ("preemptive" transplantation) tend to live longer and have higher functioning transplants than post-dialysis transplant recipients. However, researchers didn't know if higher kidney function among pre-dialysis recipients improves patients' long-term health.

To find out, Basit Javaid, MD (Stanford University School of Medicine), and his colleagues analyzed data from the United Network for Organ Sharing (UNOS) and looked at all preemptive kidney transplant recipients who received their first kidney transplant between October, 1987 and February, 2009. These 25,748 preemptive kidney transplant recipients were divided into two groups: patients with higher kidney function and patients with lower kidney function at the time of transplant.

The investigators found that patient and kidney transplant survival were similar in the two groups. "Based on these findings, we feel that patients and transplant experts anticipating a preemptive kidney transplant can wait for clinical indications to emerge without any significant loss of survival advantage associated with a preemptive transplant," said Dr. Javaid. The researchers did note, however, that patients with higher kidney function needed less dialysis within the first week after transplantation and were less often treated for kidney rejection in the first six months after transplantation.
-end-
The authors report no financial disclosures. Study co-authors include Marc Melcher, MD, Jin-Yon Kim, MD, Julie Yabu, MD, Jane Tan, MD, John Scandling, MD, and Stephan Busque, MD (Stanford University School of Medicine).

The study abstract, "Preemptive Kidney Transplant: Wouldn't Earlier Be Even Better?" (TH-PO1042) will be presented as part of a Poster Session during the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition on Oct. 29, between 10:00 am and 12:00 pm in the Scientific Exposition Hall of the San Diego Convention Center in San Diego, CA and at a Press Briefing on Oct. 29 at 12:30 pm in Room 12.

ASN Renal Week 2009, the largest nephrology meeting of its kind, will provide a forum for 13,000 professionals to discuss the latest findings in renal research and engage in educational sessions related to advances in the care of patients with kidney and related disorders. Renal Week 2009 will take place October 27 - November 1 at the San Diego Convention Center in San Diego.

Founded in 1966, the American Society of Nephrology (ASN) is the world's largest professional society devoted to the study of kidney disease. Comprised of 11,000 physicians and scientists, ASN continues to promote expert patient care, to advance medical research, and to educate the renal community. ASN also informs policymakers about issues of importance to kidney doctors and their patients. ASN funds research, and through its world-renowned meetings and first-class publications, disseminates information and educational tools that empower physicians.

American Society of Nephrology

Related Kidney Transplant Articles from Brightsurf:

The effects of social determinants of health on kidney transplant candidates
Social determinants of health are associated with patient-reported outcomes in adults who are eligible to undergo kidney transplantation evaluations.

Tailored education system to benefit kidney transplant patients
Researchers find their computer-tailored education system, 'Your Path to Transplant' increases knowledge and readiness to pursue kidney transplant.

Kidney transplant, the cost of accounting for patients' preferences
Taking into account patients' preferences can help speed up the organ allocation process and improve the life quality of the recipients, as shown by a joint study conducted by Ca' Foscari University and the University of Padua

New hope for kidney revival for transplant
Cell therapy delivered directly to the kidney can revive a 'marginal' organ, improving function and could offer new hope for providing more kidneys for transplant.

Are kidney transplant patients at higher risk? The European experience
The risk of death is relatively high in kidney transplant patients admitted to hospital with COVID-19.

The economic burden of kidney transplant failure in the United States
A recent analysis published in the American Journal of Transplantation estimates that for the average US patient who has undergone kidney transplantation, failure of the transplanted organ (graft failure) will impose additional medical costs of $78,079 and a loss of 1.66 quality-adjusted life years.

Mixed chimerism improves long-term kidney transplant outlook
Mixed chimerism - the continued mixing of donor and recipient blood cells following a transplant of blood progenitor cells - could improve outcomes for kidney transplant recipients, according to a new clinical study in about 50 patients.

Kidney paired donation is an excellent option for transplant candidates
An analysis compared transplant recipients who received kidneys through national kidney paired donation and those who received kidneys from other living donors (such as relatives, friends or other paired exchange mechanisms).

Mediterranean diet may help preserve the kidney health of transplant recipients
In a study of kidney transplant recipients, those with higher adherence to the Mediterranean diet were less likely to experience kidney function loss.

New blood test can detect rejection by antibodies after kidney transplant
A group of European scientists led by KU Leuven has found a biomarker that can identify patients with symptoms of kidney rejection symptoms after a transplant as a result of antibodies.

Read More: Kidney Transplant News and Kidney Transplant Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.